P110β in the ventromedial hypothalamus regulates glucose and energy metabolism.
Journal
Experimental & molecular medicine
ISSN: 2092-6413
Titre abrégé: Exp Mol Med
Pays: United States
ID NLM: 9607880
Informations de publication
Date de publication:
26 04 2019
26 04 2019
Historique:
received:
14
09
2018
accepted:
23
01
2019
revised:
10
01
2019
entrez:
28
4
2019
pubmed:
28
4
2019
medline:
9
6
2020
Statut:
epublish
Résumé
Phosphoinositide 3-kinase (PI3K) signaling in hypothalamic neurons integrates peripheral metabolic cues, including leptin and insulin, to coordinate systemic glucose and energy homeostasis. PI3K is composed of different subunits, each of which has several unique isoforms. However, the role of the PI3K subunits and isoforms in the ventromedial hypothalamus (VMH), a prominent site for the regulation of glucose and energy homeostasis, is unclear. Here we investigated the role of subunit p110β in steroidogenic factor-1 (SF-1) neurons of the VMH in the regulation of metabolism. Our data demonstrate that the deletion of p110β in SF-1 neurons disrupts glucose metabolism, rendering the mice insulin resistant. In addition, the deletion of p110β in SF-1 neurons leads to the whitening of brown adipose tissues and increased susceptibility to diet-induced obesity due to blunted energy expenditure. These results highlight a critical role for p110β in the regulation of glucose and energy homeostasis via VMH neurons.
Identifiants
pubmed: 31028248
doi: 10.1038/s12276-019-0249-8
pii: 10.1038/s12276-019-0249-8
pmc: PMC6486607
doi:
Substances chimiques
Steroidogenic Factor 1
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-9Subventions
Organisme : American Heart Association (American Heart Association, Inc.)
ID : 14SDG17950008
Pays : International
Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
Organisme : National Research Foundation of Korea (NRF)
ID : 2016R1A5A2008630
Pays : International
Organisme : Korea Health Industry Development Institute (KHIDI)
ID : HI17C0745
Pays : International
Organisme : National Research Foundation of Korea (NRF)
ID : 2016R1C1B3012748
Pays : International
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