Gender differential in inclination to donate brain for research among Nigerians: the IBADAN Brain Bank Project.

Adult Biomedical Research Brain Female Health Knowledge, Attitudes, Practice Humans Male Middle Aged Nigeria Sex Distribution Sex Factors Surveys and Questionnaires Tissue Banks / statistics & numerical data Tissue and Organ Procurement / statistics & numerical data
Africa Brain banking Brain donation LMIC Nigeria Willingness

Journal

Cell and tissue banking
ISSN: 1573-6814
Titre abrégé: Cell Tissue Bank
Pays: Netherlands
ID NLM: 100965121

Informations de publication

Date de publication:
Jun 2019
Historique:
received: 14 12 2018
accepted: 17 04 2019
pubmed: 28 4 2019
medline: 18 12 2019
entrez: 28 4 2019
Statut: ppublish

Résumé

Laboratory-based studies of neurological disease patterns and mechanisms are sparse in sub-Saharan Africa. However, availability of human brain tissue resource depends on willingness towards brain donation. This study evaluated the level of willingness among outpatient clinic attendees in a Nigerian teaching hospital. Under the auspices of the IBADAN Brain Bank Project, a 43-item semi-structured interviewer-administered questionnaire was designed to evaluate knowledge, attitude, and beliefs of individuals attending Neurology, Psychiatry and Geriatrics Outpatient clinics regarding willingness to donate brain for research. Association between participants characteristics and willingness towards brain donation was investigated using logistic regression models. Analysis was conducted using Stata SE version 12.0. A total of 412 participants were interviewed. Their mean age was 46.3 (16.1) years. 229 (55.6%) were females and 92.5% had at least 6 years of formal education. Overall, 109 (26.7%) were willing to donate brains for research. In analyses adjusting for educational status, religion, ethnicity, marital status and family setting, male sex showed independent association with willingness towards brain donation OR (95% CI) 1.7 (1.08-2.69), p = 0.023. Participants suggested public engagement and education through mass media (including social media) and involvement of religious and community leaders as important interventions to improve awareness and willingness towards brain donation. The survey revealed low willingness among outpatient clinic attendees to donate brain for research, although men were more inclined to donate. It is imperative to institute public engagement and educational interventions in order to improve consent for brain donation for research.

Sections du résumé

BACKGROUND BACKGROUND
Laboratory-based studies of neurological disease patterns and mechanisms are sparse in sub-Saharan Africa. However, availability of human brain tissue resource depends on willingness towards brain donation. This study evaluated the level of willingness among outpatient clinic attendees in a Nigerian teaching hospital.
METHODS METHODS
Under the auspices of the IBADAN Brain Bank Project, a 43-item semi-structured interviewer-administered questionnaire was designed to evaluate knowledge, attitude, and beliefs of individuals attending Neurology, Psychiatry and Geriatrics Outpatient clinics regarding willingness to donate brain for research. Association between participants characteristics and willingness towards brain donation was investigated using logistic regression models. Analysis was conducted using Stata SE version 12.0.
RESULTS RESULTS
A total of 412 participants were interviewed. Their mean age was 46.3 (16.1) years. 229 (55.6%) were females and 92.5% had at least 6 years of formal education. Overall, 109 (26.7%) were willing to donate brains for research. In analyses adjusting for educational status, religion, ethnicity, marital status and family setting, male sex showed independent association with willingness towards brain donation OR (95% CI) 1.7 (1.08-2.69), p = 0.023. Participants suggested public engagement and education through mass media (including social media) and involvement of religious and community leaders as important interventions to improve awareness and willingness towards brain donation.
CONCLUSION CONCLUSIONS
The survey revealed low willingness among outpatient clinic attendees to donate brain for research, although men were more inclined to donate. It is imperative to institute public engagement and educational interventions in order to improve consent for brain donation for research.

Identifiants

DOI: 10.1007/s10561-019-09769-4 PMID: 31028517 PMC: PMC6556418
pubmed: 31028517
doi: 10.1007/s10561-019-09769-4
pii: 10.1007/s10561-019-09769-4
pmc: PMC6556418
mid: NIHMS1528024
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

297-306

Subventions

Organisme : Medical Research Council
ID : G1100540
Pays : United Kingdom
Organisme : NHGRI NIH HHS
ID : U01 HG010273
Pays : United States
Organisme : National Institutes of Health (US)
ID : R01NS107900
Organisme : NIH HHS
ID : U54HG007479
Pays : United States
Organisme : NIH HHS
ID : U01HG010273
Pays : United States
Organisme : NHGRI NIH HHS
ID : U54 HG007479
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS107900
Pays : United States

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Auteurs

Rufus Akinyemi (R)

Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria. rufusakinyemi@yahoo.com.
Neuroscience and Ageing Research Unit, College of Medicine, University of Ibadan, Ibadan, Nigeria. rufusakinyemi@yahoo.com.
ORCID: 0000-0001-5286-428X

Akin Ojagbemi (A)

Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Joshua Akinyemi (J)

Department of Epidemiology and Medical Statistics, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Ayodeji Salami (A)

Department of Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Funmi Olopade (F)

Department of Anatomy, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Temitope Farombi (T)

Chief Tony Anenih Geriatric Centre, University College Hospital, Ibadan, Nigeria.

Michael Nweke (M)

Department of Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Ezinne Uvere (E)

Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Mayowa Aridegbe (M)

Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.

James Balogun (J)

Department of Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Godwin Ogbole (G)

Department of Radiology, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Ayodele Jegede (A)

Department of Sociology, Faculty of the Social Sciences, University of Ibadan, Ibadan, Nigeria.

Rajesh Kalaria (R)

Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.

Adesola Ogunniyi (A)

Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Mayowa Owolabi (M)

Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Oyedunni Arulogun (O)

Department of Health Promotion and Education, College of Medicine, University of Ibadan, Ibadan, Nigeria.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Gender differential in inclination to donate...
questionsmedicales.fr › Disciplines des sciences naturelles › Science › Recherche › Recherche biomédicale › Gender differential in inclination to donate...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Gender differential in inclination to donate...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Prestations des soins de santé › Attitude envers la santé › Connaissances, attitudes et pratiques en santé › Gender differential in inclination to donate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Gender differential in inclination to donate...
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questionsmedicales.fr › Régions géographiques › Afrique › Afrique subsaharienne › Afrique de l'Ouest › Nigeria › Gender differential in inclination to donate...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › Répartition par sexe › Gender differential in inclination to donate...
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questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Gender differential in inclination to donate...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Établissements de santé › Biobanques › Banques de tissus › Gender differential in inclination to donate...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Acquisition d'organes et de tissus › Gender differential in inclination to donate...