Salacia chinensis stem extract and its thiosugar sulfonium constituent, neokotalanol, improves HbA1c levels in ob/ob mice.
Diabetes
Functional food
Neokotalanol
Salacia
Salacia chinensis
Journal
Journal of natural medicines
ISSN: 1861-0293
Titre abrégé: J Nat Med
Pays: Japan
ID NLM: 101518405
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
27
02
2019
accepted:
10
04
2019
pubmed:
28
4
2019
medline:
14
8
2019
entrez:
28
4
2019
Statut:
ppublish
Résumé
The antidiabetic effects of a hot water extract of the stems of Salacia chinensis (SCE) were evaluated in vivo in ob/ob mice (genetically obese hyperglycemic mice). Administration of dietary feed containing 0.20 and 0.50% of SCE for 23 days to ob/ob mice significantly suppressed the elevation of both blood glucose and HbA1c levels, without significantly changing body weight and food intake. To characterize the antidiabetic effects of the thiosugar sulfonium constituent neokotalanol (1), which has potent α-glucosidase inhibitory activity, we performed a similar in vivo study. HbA1c levels were significantly suppressed in ob/ob mice after the administration of dietary feed containing 0.0003% of neokotalanol (1) for 20 days. These results indicate that SCE and neokotalanol (1) are potential leads for the development of novel antidiabetic agents.
Identifiants
pubmed: 31028661
doi: 10.1007/s11418-019-01311-w
pii: 10.1007/s11418-019-01311-w
doi:
Substances chimiques
Blood Glucose
0
Glycated Hemoglobin A
0
Glycoside Hydrolase Inhibitors
0
Hypoglycemic Agents
0
Plant Extracts
0
Thiosugars
0
neokotalanol
0
Types de publication
Journal Article
Langues
eng
Pagination
584-588Subventions
Organisme : MEXT-Supported Program for the Strategic Research Foundation at Private Universities, 2014-2018
ID : S1411037
Organisme : a Grant-in-aid for Scientific Research (KAKENHI)
ID : 18K06739
Organisme : a Grant-in-aid for Scientific Research (KAKENHI)
ID : 16K08313
Organisme : a Grant-in-aid for Scientific Research (KAKENHI)
ID : 18K06726
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