The sphingolipidome of the model organism Caenorhabditis elegans.

Animals Caenorhabditis elegans / chemistry Models, Animal Molecular Structure Sphingolipids / analysis
Caenorhabditis elegans Lipidomics Sphingolipids UPLC-UHR-ToF-MS

Journal

Chemistry and physics of lipids
ISSN: 1873-2941
Titre abrégé: Chem Phys Lipids
Pays: Ireland
ID NLM: 0067206

Informations de publication

Date de publication:
08 2019
Historique:
received: 11 02 2019
revised: 18 04 2019
accepted: 23 04 2019
pubmed: 28 4 2019
medline: 1 4 2020
entrez: 28 4 2019
Statut: ppublish

Résumé

Sphingolipids are important lipids and integral members of membranes, where they form small microdomains called lipid rafts. These rafts are enriched in cholesterol and sphingolipids, which influences biophysical properties. Interestingly, the membranes of the biomedical model organism Caenorhabditis elegans contain only low amounts of cholesterol. Sphingolipids in C. elegans are based on an unusual C17iso branched sphingoid base. In order to analyze and the sphingolipidome of C. elegans in more detail, we performed fractionation of lipid extracts and depletion of glycero- and glycerophospholipids together with in-depth analysis using UPLC-UHR-ToF-MS. In total we were able to detect 82 different sphingolipids from different classes, including several isomeric species.

Identifiants

DOI: 10.1016/j.chemphyslip.2019.04.009 PMID: 31028715
pubmed: 31028715
pii: S0009-3084(19)30042-8
doi: 10.1016/j.chemphyslip.2019.04.009
pii:
doi:

Substances chimiques

Sphingolipids 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

15-22

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Victoria Hänel (V)

Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85674 Neuherberg, Germany.

Christian Pendleton (C)

Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85674 Neuherberg, Germany.

Michael Witting (M)

Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85674 Neuherberg, Germany; Chair of Analytical Food Chemistry, Technische Universität München, Maximus-von-Imhof-Forum 2, 85354 Freising, Germany. Electronic address: michael.witting@helmholtz-muenchen.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The sphingolipidome of the model organism...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Caenorhabditis › Caenorhabditis elegans › The sphingolipidome of the model organism...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › The sphingolipidome of the model organism...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › The sphingolipidome of the model organism...
questionsmedicales.fr › Lipides › Lipides membranaires › Sphingolipides › The sphingolipidome of the model organism...