Characterization of synovial fluid metabolomic phenotypes of cartilage morphological changes associated with osteoarthritis.
Adult
Aged
Biomarkers
/ metabolism
Cartilage, Articular
/ metabolism
Chromatography, Liquid
Disease Progression
Down-Regulation
Humans
Inflammation
/ metabolism
Mass Spectrometry
Metabolomics
Middle Aged
Osteoarthritis, Knee
/ classification
Oxidative Stress
Phenotype
Severity of Illness Index
Synovial Fluid
/ metabolism
Up-Regulation
Young Adult
Biomarkers
Mass spectrometry
Metabolomics
Osteoarthritis
Synovial fluid
Systems biology
Journal
Osteoarthritis and cartilage
ISSN: 1522-9653
Titre abrégé: Osteoarthritis Cartilage
Pays: England
ID NLM: 9305697
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
20
08
2018
revised:
08
04
2019
accepted:
10
04
2019
pubmed:
28
4
2019
medline:
26
8
2020
entrez:
28
4
2019
Statut:
ppublish
Résumé
Osteoarthritis (OA) is a multifactorial disease with etiological heterogeneity. The objective of this study was to classify OA subgroups by generating metabolomic phenotypes from human synovial fluid. Post mortem synovial fluids (n = 75) were analyzed by high performance-liquid chromatography mass spectrometry (LC-MS) to measure changes in the global metabolome. Comparisons of healthy (grade 0), early OA (grades I-II), and late OA (grades III-IV) donor populations were considered to reveal phenotypes throughout disease progression. Global metabolomic profiles in synovial fluid were distinct between healthy, early OA, and late OA donors. Pathways differentially activated among these groups included structural deterioration, glycerophospholipid metabolism, inflammation, central energy metabolism, oxidative stress, and vitamin metabolism. Within disease states (early and late OA), subgroups of donors revealed distinct phenotypes. Synovial fluid metabolomic phenotypes exhibited increased inflammation (early and late OA), oxidative stress (late OA), or structural deterioration (early and late OA) in the synovial fluid. These results revealed distinct metabolic phenotypes in human synovial fluid, provide insight into pathogenesis, represent novel biomarkers, and can move toward developing personalized interventions for subgroups of OA patients.
Identifiants
pubmed: 31028882
pii: S1063-4584(19)30929-X
doi: 10.1016/j.joca.2019.04.007
pmc: PMC6646055
mid: NIHMS1529725
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1174-1184Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103474
Pays : United States
Informations de copyright
Copyright © 2019 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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