Ferritin-based anticancer metallodrug delivery: Crystallographic, analytical and cytotoxicity studies.
Drug carrier
Drug delivery
Ferritin nanoparticles
Metal-based drugs
Protein nanocages
Journal
Nanomedicine : nanotechnology, biology, and medicine
ISSN: 1549-9642
Titre abrégé: Nanomedicine
Pays: United States
ID NLM: 101233142
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
08
01
2019
revised:
28
02
2019
accepted:
03
04
2019
pubmed:
28
4
2019
medline:
5
3
2020
entrez:
28
4
2019
Statut:
ppublish
Résumé
The encapsulation of anticancer metal-based drugs within a protein nanocage represents a valuable strategy to improve the efficacy and selectivity of these compounds towards cancer cells. The preparation, characterization of the in vitro cytotoxicity and X-ray structures of several ferritin-metallodrug nanocomposites (mainly containing platinum-, ruthenium- and gold-based anticancer agents) are here reviewed. The molecular mechanisms of action of these Ft-metallodrug adducts are discussed and future directions in the field are outlined.
Identifiants
pubmed: 31028889
pii: S1549-9634(19)30081-4
doi: 10.1016/j.nano.2019.04.001
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Ferritins
9007-73-2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101997Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.