Altered materno-fetal transfer of 13C-polyunsaturated fatty acids in obese pregnant women.
Docosahexaenoic acid
Labeled fatty acids
Linoleic acid
Obesity
Placenta
Journal
Clinical nutrition (Edinburgh, Scotland)
ISSN: 1532-1983
Titre abrégé: Clin Nutr
Pays: England
ID NLM: 8309603
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
21
12
2018
revised:
08
04
2019
accepted:
11
04
2019
pubmed:
29
4
2019
medline:
19
8
2021
entrez:
29
4
2019
Statut:
ppublish
Résumé
Maternal obesity at conception is considered a major predictor of offspring obesity. This could by driven at least in part by an altered placental fat transfer. However, the pathophysiological mechanisms involved are not fully understood. We investigated the in vivo materno-fetal transfer of fatty acids (FAs) in obese pregnant women using stable isotopes. Ten obese and ten normo-weight pregnant women (control) received orally a bolus of Maternal plasma insulin and placental weight tended to higher values in obese pregnant women although they did not present serum hyperlipidemia. Higher concentrations of In conclusion, obese mothers without hyperlipidemia showed a reduced materno-fetal transfer of polyunsaturated FAs which could affect fetal development. This affect dietary recommendation for obese pregnant women. ISRCTN69794527.
Sections du résumé
BACKGROUND & AIMS
Maternal obesity at conception is considered a major predictor of offspring obesity. This could by driven at least in part by an altered placental fat transfer. However, the pathophysiological mechanisms involved are not fully understood. We investigated the in vivo materno-fetal transfer of fatty acids (FAs) in obese pregnant women using stable isotopes.
METHODS
Ten obese and ten normo-weight pregnant women (control) received orally a bolus of
RESULTS
Maternal plasma insulin and placental weight tended to higher values in obese pregnant women although they did not present serum hyperlipidemia. Higher concentrations of
CONCLUSIONS
In conclusion, obese mothers without hyperlipidemia showed a reduced materno-fetal transfer of polyunsaturated FAs which could affect fetal development. This affect dietary recommendation for obese pregnant women.
TRIAL REGISTRY NUMBER
ISRCTN69794527.
Identifiants
pubmed: 31029479
pii: S0261-5614(19)30187-6
doi: 10.1016/j.clnu.2019.04.014
pii:
doi:
Substances chimiques
Carbon Isotopes
0
Fatty Acids, Unsaturated
0
Carbon-13
FDJ0A8596D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1101-1107Informations de copyright
Copyright © 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.