Phosphoinositide switches in endocytosis and in the endolysosomal system.
Journal
Current opinion in cell biology
ISSN: 1879-0410
Titre abrégé: Curr Opin Cell Biol
Pays: England
ID NLM: 8913428
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
04
01
2019
revised:
08
03
2019
accepted:
19
03
2019
pubmed:
29
4
2019
medline:
1
4
2020
entrez:
29
4
2019
Statut:
ppublish
Résumé
Phosphoinositides (PIs) and their spatiotemporally controlled production, turnover, and interconversion is catalyzed by specific PI phosphatases and kinases and their regulators to allow rapid switching of subcompartmental PI identity. Recent studies have begun to decipher such PI switches at the molecular level and to unravel their physiological functions in endocytosis and endolysosomal membrane dynamics as well as in the control of autophagy and nutrient signaling at late endosomes/lysosomes. In this review, we summarize recent conceptual progress in the field and outline remaining perspectives and challenges for future research. As dysfunctional PI switches underlie a growing number of developmental disturbances and diseases, understanding how PI switches control endocytosis and endolysosomal function may serve to delineate new avenues for potential drug-based therapies to combat these disorders.
Identifiants
pubmed: 31029845
pii: S0955-0674(18)30131-5
doi: 10.1016/j.ceb.2019.03.011
pii:
doi:
Substances chimiques
Phosphatidylinositols
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
50-57Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.