Modulation of the mammalian coagulation system by venoms and other proteins from snakes, arthropods, nematodes and insects.
Anticoagulants
Blood coagulation
Coagulation factors
Fibrinolysis
Venom
Journal
Thrombosis research
ISSN: 1879-2472
Titre abrégé: Thromb Res
Pays: United States
ID NLM: 0326377
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
19
02
2019
revised:
04
04
2019
accepted:
15
04
2019
pubmed:
29
4
2019
medline:
3
3
2020
entrez:
29
4
2019
Statut:
ppublish
Résumé
The mammalian hemostatic system involves complex interactions between protein components of the coagulation cascade and platelets. The fibrinolytic system removes the hemostatic plug. Dysregulation of coagulation or fibrinolytic systems can induce bleeding or thrombosis. Animals, such as snakes, worms and insects, have evolved to express proteins that modulate the mammalian coagulation and fibrinolytic systems. Many of these proteins have been isolated and characterized. Understanding the mechanisms by which these exogenous factors from venoms and animal saliva modulate the mammalian coagulation and fibrinolytic systems has led to a better understanding of these systems. Furthermore, some of these exogenous proteins are used in diagnostic assays and as therapeutic drugs. This review summarizes our current knowledge of exogenous proteins from venom and saliva that either activate or inhibit the mammalian coagulation and fibrinolytic systems.
Identifiants
pubmed: 31030034
pii: S0049-3848(19)30212-9
doi: 10.1016/j.thromres.2019.04.019
pii:
doi:
Substances chimiques
Venoms
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
145-154Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.