Vitamin D increases glucocorticoid efficacy via inhibition of mTORC1 in experimental models of multiple sclerosis.

Animals Anti-Inflammatory Agents / pharmacology Calcitriol / pharmacology Encephalomyelitis, Autoimmune, Experimental / immunology Glucocorticoids / pharmacology Humans Mechanistic Target of Rapamycin Complex 1 / metabolism Mice Multiple Sclerosis Receptors, Glucocorticoid / drug effects Signal Transduction / physiology T-Lymphocytes / drug effects
Calcitriol Mammalian target of rapamycin Relapse treatment Steroid resistance c-Jun N-terminal kinase

Journal

Acta neuropathologica
ISSN: 1432-0533
Titre abrégé: Acta Neuropathol
Pays: Germany
ID NLM: 0412041

Informations de publication

Date de publication:
09 2019
Historique:
received: 07 12 2018
accepted: 20 04 2019
revised: 31 03 2019
pubmed: 29 4 2019
medline: 7 8 2020
entrez: 29 4 2019
Statut: ppublish

Résumé

The limited efficacy of glucocorticoids (GCs) during therapy of acute relapses in multiple sclerosis (MS) leads to long-term disability. We investigated the potential of vitamin D (VD) to enhance GC efficacy and the mechanisms underlying this VD/GC interaction. In vitro, GC receptor (GR) expression levels were quantified by ELISA and induction of T cell apoptosis served as a functional readout to assess synergistic 1,25(OH)

Identifiants

DOI: 10.1007/s00401-019-02018-8 PMID: 31030237 PMC: PMC6689294
pubmed: 31030237
doi: 10.1007/s00401-019-02018-8
pii: 10.1007/s00401-019-02018-8
pmc: PMC6689294
doi:

Substances chimiques

Anti-Inflammatory Agents 0
Glucocorticoids 0
Receptors, Glucocorticoid 0
Mechanistic Target of Rapamycin Complex 1 EC 2.7.11.1
Calcitriol FXC9231JVH

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

443-456

Subventions

Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 310030_172952
Pays : International
Organisme : National Health and Medical Research Council
ID : 1032486
Pays : International
Organisme : NHRMC
ID : 1080518
Pays : International

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Auteurs

Robert Hoepner (R)

Department of Neurology, Inselspital Bern, University Hospital, University of Bern, Bern, Switzerland. robert.hoepner@insel.ch.
ORCID: 0000-0002-0115-7021

Maud Bagnoud (M)

Department of Neurology, Inselspital Bern, University Hospital, University of Bern, Bern, Switzerland.

Maximilian Pistor (M)

Department of Neurology, Inselspital Bern, University Hospital, University of Bern, Bern, Switzerland.
Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.

Anke Salmen (A)

Department of Neurology, Inselspital Bern, University Hospital, University of Bern, Bern, Switzerland.

Myriam Briner (M)

Department of Neurology, Inselspital Bern, University Hospital, University of Bern, Bern, Switzerland.

Helen Synn (H)

Institute of Neuropathology, University Medical Center Goettingen, Goettingen, Germany.

Lisa Schrewe (L)

Department of Neurology, Inselspital Bern, University Hospital, University of Bern, Bern, Switzerland.

Kirsten Guse (K)

Department of Neurology, Inselspital Bern, University Hospital, University of Bern, Bern, Switzerland.

Farhad Ahmadi (F)

Department of Neurology, Inselspital Bern, University Hospital, University of Bern, Bern, Switzerland.

Seray Demir (S)

Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.

Louis Laverick (L)

Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia.

Melissa Gresle (M)

Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia.

Paul Worley (P)

The Solomon H. Snyder Department of Neuroscience, School of Medicine, John Hopkins University, Baltimore, USA.

Holger Michael Reichardt (HM)

Institute for Cellular and Molecular Immunology, University Medical Center Goettingen, Georg-August-University Goettingen, Goettingen, Germany.

Helmut Butzkueven (H)

Department of Neuroscience, Central Clinical School, Alfred Campus, Monash University, Melbourne, Australia.

Ralf Gold (R)

Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.

Imke Metz (I)

Institute of Neuropathology, University Medical Center Goettingen, Goettingen, Germany.

Fred Lühder (F)

Institute of Neuroimmunology and Multiple Sclerosis Research, University Medical Center Goettingen, Georg-August-University Goettingen, Goettingen, Germany.

Andrew Chan (A)

Department of Neurology, Inselspital Bern, University Hospital, University of Bern, Bern, Switzerland. andrew.chan@insel.ch.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Vitamin D increases glucocorticoid efficacy...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Vitamin D increases glucocorticoid efficacy...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholécalciférol › Hydroxycholécalciférols › Dihydroxycholécalciférols › Calcitriol › Vitamin D increases glucocorticoid efficacy...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Maladie neurologique auto-immune expérimentale › Encéphalomyélite auto-immune expérimentale › Vitamin D increases glucocorticoid efficacy...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Glucocorticoïdes › Vitamin D increases glucocorticoid efficacy...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Vitamin D increases glucocorticoid efficacy...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › Complexe-1 cible mécanistique de la rapamycine › Vitamin D increases glucocorticoid efficacy...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Vitamin D increases glucocorticoid efficacy...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Vitamin D increases glucocorticoid efficacy...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs aux glucocorticoïdes › Vitamin D increases glucocorticoid efficacy...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Vitamin D increases glucocorticoid efficacy...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Vitamin D increases glucocorticoid efficacy...