In vitro evaluation of the cariogenic potential of rebaudioside A compared to sucrose and xylitol.
Acid production
Bacterial growth
Mutans streptococci
Rebaudioside A
Sugar substitutes
Xylitol
Journal
Clinical oral investigations
ISSN: 1436-3771
Titre abrégé: Clin Oral Investig
Pays: Germany
ID NLM: 9707115
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
15
01
2019
accepted:
09
04
2019
pubmed:
29
4
2019
medline:
7
2
2020
entrez:
29
4
2019
Statut:
ppublish
Résumé
The aim of the present study was to evaluate the growth and acid synthesis of cariogenic pathogens in vitro when rebaudioside A was the sole source of carbon, compared to sucrose, xylitol, and a commercial sweetener containing rebaudioside A. First, sucrose or sugar substitutes were added to human saliva and the pH was measured over 10 h. Subsequently, the growth and acid synthesis efficiency of Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Lactobacillus rhamnosus, Lactobacillus paracasei, and Candida albicans were investigated: after adding them to minimal culture media containing only one of the carbon sources, the optical density and pH were determined over 10 h. A significant pH drop only occurred in the sucrose group of human saliva whereas no differences were found between the sugar substitute groups. The individual strains of caries pathogens showed significantly lower growth rates and less acid synthesis in the sugar replacement groups, in comparison to sucrose. However, these groups also showed bacterial growth and a decline in pH. Xylitol appeared to be superior to rebaudioside A regarding the inhibition of mutans streptococci. The results for the remaining microorganisms indicate that rebaudioside A causes a similar or lower acid synthesis than xylitol. As saliva contains buffer systems, the metabolism of rebaudioside A did not seem to shift the equilibrium to demineralization. Rebaudioside A may not be suitable as a targeted Streptococcus mutans treatment, but it could contribute to a reduction of caries risk as a replacement for sucrose.
Identifiants
pubmed: 31030274
doi: 10.1007/s00784-019-02908-x
pii: 10.1007/s00784-019-02908-x
doi:
Substances chimiques
Diterpenes, Kaurane
0
Sucrose
57-50-1
rebaudioside A
B3FUD0528F
Xylitol
VCQ006KQ1E
Types de publication
Journal Article
Langues
eng
Pagination
113-122Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : AL 1179/2-1
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