Molecular Comprehension of Mcl-1: From Gene Structure to Cancer Therapy.
BH3 mimetics
Bcl-2 family
Mcl-1
apoptosis
Journal
Trends in cell biology
ISSN: 1879-3088
Titre abrégé: Trends Cell Biol
Pays: England
ID NLM: 9200566
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
19
02
2019
revised:
14
03
2019
accepted:
19
03
2019
pubmed:
30
4
2019
medline:
2
6
2020
entrez:
30
4
2019
Statut:
ppublish
Résumé
Among cell death regulators, members of the Bcl-2 family are of interest because they are highly conserved across species and represent promising targets for anticancer therapy. This family and its associated proteins include more than 25 members, with either anti- or proapoptotic functions. Although the overall regulation of apoptosis by Bcl-2 family proteins is now well understood, targeted therapy requires careful consideration of individual members of the family and their crosstalk. One of the most studied representatives of the Bcl-2 family is antiapoptotic Mcl-1. After 25 years of investigations, a large amount of data regarding Mcl-1's regulation and functions has been compiled. In this review, we summarize current knowledge about Mcl-1, focusing on molecular aspects relevant to Mcl-1-targeted therapies.
Identifiants
pubmed: 31030977
pii: S0962-8924(19)30047-9
doi: 10.1016/j.tcb.2019.03.004
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
MCL1 protein, human
0
Myeloid Cell Leukemia Sequence 1 Protein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
549-562Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.