Pattern of Antimicrobial Sensitivity in Microbiologically Documented Infections in Neutropenic Patients with Haematological Malignancies: A single Center Study.
Antibiotic sensitivity
Febrile neutropenia
Haematological malignancies
Microbiological spectrum
Microbiologically documented infections
Journal
Indian journal of microbiology
ISSN: 0046-8991
Titre abrégé: Indian J Microbiol
Pays: India
ID NLM: 0374703
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
29
12
2018
accepted:
26
02
2019
entrez:
30
4
2019
pubmed:
30
4
2019
medline:
30
4
2019
Statut:
ppublish
Résumé
Febrile neutropenia is a medical emergency that complicates the clinical course and treatment of haematological malignancies, significantly enhancing the financial burden and worsening the overall outcome. This study was carried out to evaluate the efficacy of institution's current first-line antibiotic regimen for febrile neutropenia in view of recent spectrum of institution's local flora and its susceptibility pattern. 163 episodes of microbiologically documented infections in 110 adult patients were studied over a period of 1 year. Of 110 patients, 61 patients were male. The mean age of the patient population, mean absolute neutrophil count and temperature as documented were 30.1 years (SD ± 16.8), 450 cells/ul, and 101.9 °C respectively. Gram-negative and gram-positive organisms accounted for 79% and 21% of the febrile neutropenic infections respectively.
Identifiants
pubmed: 31031433
doi: 10.1007/s12088-019-00789-y
pii: 789
pmc: PMC6458217
doi:
Types de publication
Journal Article
Langues
eng
Pagination
188-192Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interest.This study was approved by the Institutional Review Board and informed consent was taken from the participants prior to the study.
Références
Clin Infect Dis. 2005 Apr 1;40 Suppl 4:S240-5
pubmed: 15768329
J Postgrad Med. 2005;51 Suppl 1:S42-8
pubmed: 16519255
J Coll Physicians Surg Pak. 2006 Nov;16(11):704-8
pubmed: 17052420
J Antimicrob Chemother. 2008 Mar;61(3):721-8
pubmed: 18218645
J Infect Dev Ctries. 2008 Oct 01;2(5):359-63
pubmed: 19745503
Ann Oncol. 2010 May;21 Suppl 5:v252-6
pubmed: 20555092
Indian J Hematol Blood Transfus. 2011 Sep;27(3):131-5
pubmed: 22942562
Rev Bras Hematol Hemoter. 2013;35(1):18-22
pubmed: 23580879
Caspian J Intern Med. 2013 Summer;4(3):698-701
pubmed: 24009963
Indian J Med Paediatr Oncol. 2013 Apr;34(2):85-8
pubmed: 24049293
Clin Infect Dis. 2014 Nov 15;59 Suppl 5:S335-9
pubmed: 25352627
Adv Hematol. 2014;2014:986938
pubmed: 25525436
Indian J Hematol Blood Transfus. 2015 Mar;31(1):46-50
pubmed: 25548444
Turk J Haematol. 2015 Sep;32(3):243-50
pubmed: 25913035
J Oncol. 2015;2015:596504
pubmed: 26290665
J Lab Physicians. 2015 Jul-Dec;7(2):116-20
pubmed: 26417163
Virulence. 2016 Apr 2;7(3):280-97
pubmed: 27002635
J Clin Microbiol. 2016 Nov;54(11):2635-2646
pubmed: 27280421
Indian J Med Paediatr Oncol. 2016 Jul-Sep;37(3):174-82
pubmed: 27688611
J Oncol Pract. 2017 Jun;13(6):e552-e561
pubmed: 28437150
World J Oncol. 2014 Dec;5(5-6):196-203
pubmed: 29147403
Indian J Crit Care Med. 2018 May;22(5):336-339
pubmed: 29910543
J Res Pharm Pract. 2018 Jul-Sep;7(3):147-156
pubmed: 30211240