Potent Inhibition of Zika Virus Replication by Aurintricarboxylic Acid.
Flavivirus
Zika virus
antivirals
aurintricarboxylic acid
drug treatment
prophylactic
therapeutic
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2019
2019
Historique:
received:
05
02
2019
accepted:
21
03
2019
entrez:
30
4
2019
pubmed:
30
4
2019
medline:
30
4
2019
Statut:
epublish
Résumé
Zika virus (ZIKV) is one of the recently emerging vector-borne viruses in humans and is responsible for severe congenital abnormalities such as microcephaly in the Western Hemisphere. Currently, only a few vaccine candidates and therapeutic drugs are being developed for the treatment of ZIKV infections, and as of yet none are commercially available. The polyanionic aromatic compound aurintricarboxylic acid (ATA) has been shown to have a broad-spectrum antimicrobial and antiviral activity. In this study, we evaluated ATA as a potential antiviral drug against ZIKV replication. The antiviral activity of ATA against ZIKV replication
Identifiants
pubmed: 31031722
doi: 10.3389/fmicb.2019.00718
pmc: PMC6473159
doi:
Types de publication
Journal Article
Langues
eng
Pagination
718Subventions
Organisme : NIAID NIH HHS
ID : R21 AI130500
Pays : United States
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