The Cerebrospinal Fluid in Multiple Sclerosis.
CSF (cerebrospinal fluid)
biomarker
multiple sclerosis
neurofilament light (NfL)
oligoclonal band (OCB)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
22
11
2018
accepted:
18
03
2019
entrez:
30
4
2019
pubmed:
30
4
2019
medline:
11
8
2020
Statut:
epublish
Résumé
Investigation of cerebrospinal fluid (CSF) in the diagnostic work-up in suspected multiple sclerosis (MS) patients has regained attention in the latest version of the diagnostic criteria due to its good diagnostic accuracy and increasing issues with misdiagnosis of MS based on over interpretation of neuroimaging results. The hallmark of MS-specific changes in CSF is the detection of oligoclonal bands (OCB) which occur in the vast majority of MS patients. Lack of OCB has a very high negative predictive value indicating a red flag during the diagnostic work-up, and alternative diagnoses should be considered in such patients. Additional molecules of CSF can help to support the diagnosis of MS, improve the differential diagnosis of MS subtypes and predict the course of the disease, thus selecting the optimal therapy for each patient.
Identifiants
pubmed: 31031747
doi: 10.3389/fimmu.2019.00726
pmc: PMC6473053
doi:
Substances chimiques
Aquaporin 4
0
Biomarkers
0
Neurofilament Proteins
0
Oligoclonal Bands
0
neurofilament protein L
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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