Targeted, High-Resolution RNA Sequencing of Non-coding Genomic Regions Associated With Neuropsychiatric Functions.
GWAS
RNA-seq
brain
haplotype blocks
long-read sequencing
non-coding RNA
sequins
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2019
2019
Historique:
received:
03
02
2019
accepted:
21
03
2019
entrez:
30
4
2019
pubmed:
30
4
2019
medline:
30
4
2019
Statut:
epublish
Résumé
The human brain is one of the last frontiers of biomedical research. Genome-wide association studies (GWAS) have succeeded in identifying thousands of haplotype blocks associated with a range of neuropsychiatric traits, including disorders such as schizophrenia, Alzheimer's and Parkinson's disease. However, the majority of single nucleotide polymorphisms (SNPs) that mark these haplotype blocks fall within non-coding regions of the genome, hindering their functional validation. While some of these GWAS loci may contain
Identifiants
pubmed: 31031799
doi: 10.3389/fgene.2019.00309
pmc: PMC6473190
doi:
Types de publication
Journal Article
Langues
eng
Pagination
309Subventions
Organisme : NIAAA NIH HHS
ID : R28 AA012725
Pays : United States
Références
Genome Res. 2007 Sep;17(9):1245-53
pubmed: 17690206
Cell Syst. 2018 Feb 28;6(2):245-255.e5
pubmed: 29396323
Am J Hum Genet. 2013 Nov 7;93(5):779-97
pubmed: 24210251
Nat Commun. 2020 Mar 18;11(1):1438
pubmed: 32188845
Mol Psychiatry. 2017 Apr;22(4):497-511
pubmed: 28044063
Nat Struct Mol Biol. 2013 Mar;20(3):300-7
pubmed: 23463315
Nature. 2014 Mar 27;507(7493):462-70
pubmed: 24670764
Nat Protoc. 2016 Sep;11(9):1650-67
pubmed: 27560171
Am J Hum Genet. 2012 Jan 13;90(1):7-24
pubmed: 22243964
Am J Hum Genet. 2017 Jul 6;101(1):5-22
pubmed: 28686856
Nature. 2009 Aug 6;460(7256):744-7
pubmed: 19571808
Nat Methods. 2015 Apr;12(4):339-42
pubmed: 25751143
Endocrinology. 1999 Jan;140(1):335-43
pubmed: 9886843
Nat Biotechnol. 2016 Dec;34(12):1279-1286
pubmed: 27798563
Science. 2005 Sep 2;309(5740):1564-6
pubmed: 16141073
Brief Bioinform. 2013 Mar;14(2):144-61
pubmed: 22908213
Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):716-21
pubmed: 18184812
Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11830-5
pubmed: 22753485
Nat Rev Genet. 2016 Apr;17(4):207-23
pubmed: 26948815
J Cell Biol. 2009 Sep 7;186(5):637-44
pubmed: 19720872
Nat Biotechnol. 2011 Nov 13;30(1):99-104
pubmed: 22081020
Nat Methods. 2013 Dec;10(12):1177-84
pubmed: 24185837
Nat Rev Genet. 2016 Jan;17(1):47-62
pubmed: 26666209
Front Genet. 2014 Feb 18;5:39
pubmed: 24600475
Genome Biol. 2016 Apr 14;17:67
pubmed: 27081004
Genome Res. 2018 Feb;28(2):231-242
pubmed: 29196558
Nat Rev Genet. 2018 Sep;19(9):535-548
pubmed: 29795125
Genome Res. 2016 May;26(5):705-16
pubmed: 27197243
Nucleic Acids Res. 2008 Jan;36(Database issue):D190-5
pubmed: 18045787
Genome Res. 2005 Aug;15(8):1034-50
pubmed: 16024819
Nat Rev Genet. 2017 Aug;18(8):473-484
pubmed: 28626224
Trends Genet. 2018 Sep;34(9):704-721
pubmed: 30017313
Nucleic Acids Res. 2015 Feb 18;43(3):1859-68
pubmed: 25618847
Nucleic Acids Res. 2013 May 1;41(10):e108
pubmed: 23558742
Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9362-7
pubmed: 19474294
Nat Methods. 2016 Sep;13(9):792-8
pubmed: 27502218
Bioinformatics. 2008 Dec 15;24(24):2938-9
pubmed: 18974171
Biol Psychiatry. 2011 Sep 15;70(6):513-8
pubmed: 21529783
Genome Res. 2012 Sep;22(9):1775-89
pubmed: 22955988
Nature. 2014 Jul 24;511(7510):421-7
pubmed: 25056061
Science. 2005 Sep 2;309(5740):1559-63
pubmed: 16141072
Nature. 2011 Aug 10;476(7359):214-9
pubmed: 21833088
Nat Biotechnol. 2015 Jul;33(7):736-42
pubmed: 25985263
Nat Protoc. 2014 May;9(5):989-1009
pubmed: 24705597
PLoS One. 2009;4(2):e4653
pubmed: 19247474
Nature. 2014 Jan 30;505(7485):706-9
pubmed: 24476892
Nat Biotechnol. 2015 Mar;33(3):290-5
pubmed: 25690850
Nature. 2015 Feb 19;518(7539):317-30
pubmed: 25693563
Trends Genet. 2017 Jul;33(7):464-478
pubmed: 28535931
Genome Res. 2015 Feb;25(2):290-303
pubmed: 25561518
Nat Struct Mol Biol. 2015 Jan;22(1):29-35
pubmed: 25565030
Mol Cell. 2015 Oct 15;60(2):208-19
pubmed: 26412307
Genome Res. 2017 Aug;27(8):1371-1383
pubmed: 28487280
Genome Res. 2012 Sep;22(9):1760-74
pubmed: 22955987
Nat Genet. 2017 Dec;49(12):1731-1740
pubmed: 29106417
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Nucleic Acids Res. 2017 Jan 4;45(D1):D896-D901
pubmed: 27899670
Genome Biol. 2015 Sep 30;16:204
pubmed: 26420219
Nat Biotechnol. 2011 Jan;29(1):24-6
pubmed: 21221095
Genome Res. 2011 Sep;21(9):1543-51
pubmed: 21816910
Genome Biol. 2017 Dec 28;18(1):241
pubmed: 29284497
Nucleic Acids Res. 1997 Sep 1;25(17):3389-402
pubmed: 9254694
Nat Genet. 2015 Mar;47(3):199-208
pubmed: 25599403
Neuron. 2015 Dec 2;88(5):861-877
pubmed: 26637795
Nat Protoc. 2013 Aug;8(8):1494-512
pubmed: 23845962
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Nat Commun. 2017 Jul 19;8:16027
pubmed: 28722025
Nat Methods. 2017 Apr;14(4):417-419
pubmed: 28263959
Nucleic Acids Res. 2013 Apr 1;41(6):e74
pubmed: 23335781
Bioinformatics. 2018 Sep 15;34(18):3094-3100
pubmed: 29750242
Nat Rev Genet. 2015 Apr;16(4):197-212
pubmed: 25707927
Bioinformatics. 2010 Mar 15;26(6):841-2
pubmed: 20110278
Nucleic Acids Res. 2014 Jan;42(Database issue):D1001-6
pubmed: 24316577
Mol Psychiatry. 2014 Jun;19(6):717-23
pubmed: 23958962
Science. 2017 Jan 6;355(6320):
pubmed: 27980086