Interactive Effects of Exercise, Sex Hormones, and Transient Congenital Hypothyroidism on Long-Term Potentiation in Hippocampal Slices of Rat Offspring.
Exercise
Hypothyroid
Long-Term Potentiation
Sex hormones
Journal
Basic and clinical neuroscience
ISSN: 2008-126X
Titre abrégé: Basic Clin Neurosci
Pays: Iran
ID NLM: 101575211
Informations de publication
Date de publication:
Historique:
received:
13
11
2017
revised:
25
12
2017
accepted:
30
04
2018
entrez:
30
4
2019
pubmed:
30
4
2019
medline:
30
4
2019
Statut:
ppublish
Résumé
The long-term adverse effects of transient thyroid function abnormalities at birth on intellectual development are proven. The effect of exercise increases in the presence of sex hormones. The current study aimed at investigating the possibility that a combination of sex hormones and exercise has synergistic effects on neural plasticity in Transient Congenital Hypothyroidism (TCH) rats. To induce hypothyroidism in the mothers, Propylthiouracil (PTU) was added to drinking water (100 mg/L) on the 6th day of gestation and continued until the 21 Increase of Long-Term Potentiation (LTP) was observed in sedentary-non-hormone female rats of TCH group, compared with that of the control. The exercise enhanced LTP in control rats, but the hormones showed no significant effect. The effect of exercise and sex hormone was not significant in the TCH group. The combination of exercise and testosterone enhanced LTP in TCH male rats, while the combination of exercise and estradiol or each of them individually did not produce such an effect on LTP in TCH female rats. The study findings showed an increase in excitatory transmission despite the returning of thyroid hormone levels to normal range in TCH female rats. Also a combination treatment including exercise and testosterone enhanced LTP in male rats of TCH group, which was a gender-specific event.
Identifiants
pubmed: 31031899
doi: 10.32598/bcn.9.10.170
pii: bcn-10-119
pmc: PMC6484195
doi:
Types de publication
Journal Article
Langues
eng
Pagination
119-135Déclaration de conflit d'intérêts
Conflict of interest The authors declared no conflict of interest.
Références
Neuropharmacology. 1999 Jan;38(1):65-71
pubmed: 10193899
J Cell Biochem. 1999 Jun 15;73(4):554-62
pubmed: 10733348
Endocr Res. 2000 Aug;26(3):411-29
pubmed: 11019905
Fertil Steril. 2000 Dec;74(6):1063-70
pubmed: 11119728
Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9401-6
pubmed: 11447296
J Appl Physiol (1985). 2001 Dec;91(6):2785-801
pubmed: 11717247
Neuroscience. 2002;109(3):517-30
pubmed: 11823063
J Endocrinol Invest. 2002 Mar;25(3):268-88
pubmed: 11936472
Neuron. 2002 Jun 13;34(6):945-60
pubmed: 12086642
Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11946-50
pubmed: 12181492
Exp Neurol. 2003 Aug;182(2):470-5
pubmed: 12895458
Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):865-70
pubmed: 14694190
Brain Res Dev Brain Res. 2004 Jan 31;148(1):11-8
pubmed: 14757514
Hippocampus. 2004;14(1):40-5
pubmed: 15058481
J Neurosci. 2004 Jun 30;24(26):5913-21
pubmed: 15229239
Neuron. 2004 Sep 30;44(1):109-20
pubmed: 15450164
Neurotoxicology. 2005 Jun;26(3):417-26
pubmed: 15935212
J Neurosci. 2005 Sep 21;25(38):8680-5
pubmed: 16177036
Neuro Endocrinol Lett. 2005 Dec;26(6):830-4
pubmed: 16380698
Biochem J. 1941 Jun;35(5-6):726-35
pubmed: 16747441
J Neurosci Res. 2006 Oct;84(5):934-43
pubmed: 16902997
Science. 2006 Aug 25;313(5790):1093-7
pubmed: 16931756
Ann N Y Acad Sci. 2006 Aug;1074:427-37
pubmed: 17105941
Trends Neurosci. 2007 Sep;30(9):464-72
pubmed: 17765329
Neuromolecular Med. 2008;10(2):128-40
pubmed: 18286389
Environ Health Perspect. 2008 Mar;116(3):308-14
pubmed: 18335096
J Neuroendocrinol. 2008 Jun;20(6):784-94
pubmed: 18601701
Neurobiol Dis. 2009 May;34(2):366-74
pubmed: 19233274
J Physiol. 2009 Jul 1;587(Pt 13):3221-31
pubmed: 19451201
Endocrinology. 2009 Nov;150(11):5106-12
pubmed: 19589866
Brain Res. 2009 Nov 3;1296:1-14
pubmed: 19686713
Neuroscience. 2010 May 19;167(3):588-97
pubmed: 20219647
Physiol Behav. 2010 Dec 2;101(5):660-5
pubmed: 20888848
Behav Brain Res. 2011 Apr 15;218(2):308-14
pubmed: 21192984
Neuroscience. 2011 Jun 2;183:25-31
pubmed: 21458541
Neurotoxicol Teratol. 2011 Jul-Aug;33(4):464-72
pubmed: 21530650
Maturitas. 2011 Aug;69(4):322-37
pubmed: 21696899
Cell Tissue Res. 2011 Sep;345(3):285-94
pubmed: 21826442
J Thyroid Res. 2011;2011:843591
pubmed: 21876837
Indian J Endocrinol Metab. 2011 Jul;15(Suppl 2):S117-20
pubmed: 21966647
PLoS One. 2012;7(6):e38018
pubmed: 22675505
Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13100-5
pubmed: 22807478
Neurosci Lett. 2012 Oct 24;528(2):201-4
pubmed: 22982147
Int J Dev Neurosci. 2013 May;31(3):214-23
pubmed: 23328696
Acta Physiol Hung. 2013 Jun;100(2):197-210
pubmed: 23708947
Behav Neurosci. 2013 Oct;127(5):744-54
pubmed: 23978149
Int J Dev Neurosci. 2013 Dec;31(8):790-5
pubmed: 24120877
Iran J Basic Med Sci. 2013 Sep;16(9):979-84
pubmed: 24171076
Dev Psychobiol. 2014 Sep;56(6):1179-86
pubmed: 24464467
Front Hum Neurosci. 2014 Apr 01;8:191
pubmed: 24744721
Neuroscience. 2014 Aug 22;274:24-32
pubmed: 24846612
Nature. 2014 Jul 17;511(7509):348-52
pubmed: 24896183
Brain Res. 2015 Sep 24;1621:82-101
pubmed: 25451089
Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4128-33
pubmed: 25775598
Neuroscience. 2015 Jul 9;298:357-66
pubmed: 25917310
Front Neuroendocrinol. 2016 Jan;40:24-41
pubmed: 26182835
Neuroscience. 2015 Dec 17;311:284-91
pubmed: 26518460
Hippocampus. 2016 Jul;26(7):933-46
pubmed: 26860755
Neuroscience. 2016 Aug 4;329:151-61
pubmed: 27181637
Toxicol Lett. 2017 Mar 5;269:55-64
pubmed: 28185983
Int J Dev Neurosci. 2017 Aug;60:56-62
pubmed: 28455226
Front Cell Neurosci. 2017 May 16;11:140
pubmed: 28559797
Neurosci Lett. 1986 Jul 24;68(2):169-74
pubmed: 2875420
Brain Res. 1987 Feb 24;404(1-2):89-94
pubmed: 2882811
Fed Proc. 1977 Jun;36(7):1973-7
pubmed: 324816
Brain Res. 1988 Apr 1;467(2):245-51
pubmed: 3378173
Brain Res. 1985 Apr 29;333(1):73-80
pubmed: 3995290
J Neurosci Res. 1985;14(1):61-9
pubmed: 4020898
Endocrinology. 1983 Sep;113(3):921-8
pubmed: 6872961
Clin Endocrinol (Oxf). 1995 Oct;43(4):473-7
pubmed: 7586623
Psychol Bull. 1995 Jul;118(1):55-107
pubmed: 7644606
Nature. 1993 Jan 7;361(6407):31-9
pubmed: 8421494
Nutr Rev. 1996 Apr;54(4 Pt 2):S72-8
pubmed: 8700456
Hippocampus. 1997;7(1):95-110
pubmed: 9138673
Brain Res. 1997 Dec 19;778(2):430-8
pubmed: 9459564
Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):15037-42
pubmed: 9844011