The role of sclerostin and dickkopf-1 in oral tissues - A review from the perspective of the dental disciplines.
Dickkopf-1
Endodontology
Periodontology
Regeneration
Sclerostin
Wnt Pathway
Journal
F1000Research
ISSN: 2046-1402
Titre abrégé: F1000Res
Pays: England
ID NLM: 101594320
Informations de publication
Date de publication:
2019
2019
Historique:
accepted:
18
01
2019
entrez:
30
4
2019
pubmed:
30
4
2019
medline:
13
6
2020
Statut:
epublish
Résumé
Wnt signaling is of high relevance in the development, homeostasis, and regeneration of oral tissues. Therefore, Wnt signaling is considered to be a potential target for therapeutic strategies. The action of Wnt is tightly controlled by the inhibitors sclerostin (SOST) and Dickkopf (DKK)-1. Given the impact of SOST and DKK-1 in hard tissue formation, related diseases and healing, it is of high relevance to understand their role in oral tissues. The clinical relevance of this knowledge is further underlined by systemic and local approaches which are currently in development for treating a variety of diseases such as osteoporosis and inflammatory hard tissue resorption. In this narrative review, we summarize the current knowledge and understanding on the Wnt signaling inhibitors SOST and DKK-1, and their role in physiology, pathology, and regeneration in oral tissues. We present this role from the perspective of the different specialties in dentistry, including endodontics, orthodontics, periodontics, and oral surgery.
Identifiants
pubmed: 31031968
doi: 10.12688/f1000research.17801.1
pmc: PMC6468704
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
DKK1 protein, human
0
Intercellular Signaling Peptides and Proteins
0
SOST protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
128Déclaration de conflit d'intérêts
No competing interests were disclosed.
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