DNA methylation signatures as biomarkers of prior environmental exposures.
DNA methylation
EWAS
biomarker
environmental exposure
epigenomic
past exposure
prenatal smoking
Journal
Current epidemiology reports
ISSN: 2196-2995
Titre abrégé: Curr Epidemiol Rep
Pays: Switzerland
ID NLM: 101626185
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
entrez:
30
4
2019
pubmed:
30
4
2019
medline:
30
4
2019
Statut:
ppublish
Résumé
This review demonstrates the growing body of evidence connecting DNA methylation to prior exposure. It highlights the potential to use DNA methylation patterns as a feasible, stable, and accurate biomarker of past exposure, opening new opportunities for environmental and gene-environment interaction studies among existing banked samples. We present the evidence for association between past exposure, including prenatal exposures, and DNA methylation measured at a later time in the life course. We demonstrate the potential utility of DNA methylation-based biomarkers of past exposure using results from multiple studies of smoking as an example. Multiple studies show the ability to accurately predict prenatal smoking exposure based on DNA methylation measured at birth, in childhood, and even adulthood. Separate sets of DNA methylation loci have been used to predict past personal smoking exposure (postnatal) as well. Further, it appears that these two types of exposures, prenatal and previous personal exposure, can be isolated from each other. There is also a suggestion that quantitative methylation scores may be useful for estimating dose. We highlight the remaining needs for rigor in methylation biomarker development including analytic challenges as well as the need for development across multiple developmental windows, multiple tissue types, and multiple ancestries. If fully developed, DNA methylation-based biomarkers can dramatically shift our ability to carry out environmental and genetic-environmental epidemiology using existing biobanks, opening up unprecedented opportunities for environmental health.
Identifiants
pubmed: 31032172
doi: 10.1007/s40471-019-0178-z
pmc: PMC6481677
mid: NIHMS1525000
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1-13Subventions
Organisme : Autism Speaks
ID : AS7659
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES017646
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES025531
Pays : United States
Organisme : NCBDD CDC HHS
ID : U01 DD001214
Pays : United States
Déclaration de conflit d'intérêts
Conflict of Interest M. Daniele Fallin and Christine Ladd-Acosta each declare no potential conflicts of interest.
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