Vemurafenib Treatment of Pleomorphic Xanthoastrocytoma in a Child With Down Syndrome.

BRAF V600E mutation brain tumor down syndrome pleomorphic xanthoastrocytoma vemurafenib

Journal

Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867

Informations de publication

Date de publication:
2019
Historique:
received: 10 11 2018
accepted: 26 03 2019
entrez: 30 4 2019
pubmed: 30 4 2019
medline: 30 4 2019
Statut: epublish

Résumé

Brain tumors are the most common solid neoplasms of childhood, but they are very rarely reported in children with Down Syndrome (DS), who develop more commonly different types of malignancies. In particular, we hereby report the case of an 8-years-old child with DS that presented to our attention for neurological and endocrinological issues. Brain imaging revealed the presence of a mass that was partially resected revealing a histological diagnosis of Pleomorphic Xanthoastrocytoma (PXA), a rare WHO grade II tumor extending from the diencephalic region into the surrounding brain tissue. These tumors can harbor the

Identifiants

pubmed: 31032231
doi: 10.3389/fonc.2019.00277
pmc: PMC6474392
doi:

Types de publication

Case Reports

Langues

eng

Pagination

277

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Auteurs

Giuseppe Petruzzellis (G)

Department of Hematology, Oncology and Stem Cell Transplantation, Bambino Gesù Children's Hospital (IRCCS), Rome, Italy.

Diletta Valentini (D)

Pediatric and Infectious Disease Unit, Bambino Gesù Children's Hospital (IRCCS), Rome, Italy.

Francesca Del Bufalo (F)

Department of Hematology, Oncology and Stem Cell Transplantation, Bambino Gesù Children's Hospital (IRCCS), Rome, Italy.

Giulia Ceglie (G)

University Department of Pediatrics, Bambino Gesù Children's Hospital, University of Rome Tor Vergata, Rome, Italy.

Andrea Carai (A)

Neurosurgery Unit, Department of Neuroscience and Neurorehabilitation, Bambino Gesù Children's Hospital (IRCCS), Rome, Italy.

Giovanna Stefania Colafati (GS)

Neuroradiology Unit, Department of Imaging, Bambino Gesù Children's Hospital (IRCCS), Rome, Italy.

Emanuele Agolini (E)

Medical Genetics Laboratory, Bambino Gesù Paediatric Hospital (IRCCS), Rome, Italy.

Francesca Diomedi-Camassei (F)

Department of Pathology, Bambino Gesù Children's Hospital (IRCCS), Rome, Italy.

Tiziana Corsetti (T)

Hospital Pharmacy Unit, Children's Hospital and Research Institute 'Bambino Gesù' (IRCCS), Rome, Italy.

Iside Alessi (I)

Department of Hematology, Oncology and Stem Cell Transplantation, Bambino Gesù Children's Hospital (IRCCS), Rome, Italy.

Angela Mastronuzzi (A)

Neuro-oncology Unit, Department of Hematology, Oncology and Stem Cell Transplantation, Bambino Gesù Children's Hospital (IRCCS), Rome, Italy.

Franco Locatelli (F)

Department of Hematology, Oncology and Stem Cell Transplantation, Bambino Gesù Children's Hospital (IRCCS), Rome, Italy.
Department of Gynecology/Obstetrics and Pediatrics, Sapienza University of Rome, Rome, Italy.

Antonella Cacchione (A)

Neuro-oncology Unit, Department of Hematology, Oncology and Stem Cell Transplantation, Bambino Gesù Children's Hospital (IRCCS), Rome, Italy.

Classifications MeSH