Thalamocortical synapses in the cat visual system in vivo are weak and unreliable.
neuroscience
synaptic dynamics
thalmocortical
visual cortex
visual thalamus
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
29 04 2019
29 04 2019
Historique:
received:
11
09
2018
accepted:
27
04
2019
pubmed:
30
4
2019
medline:
27
2
2020
entrez:
30
4
2019
Statut:
epublish
Résumé
The thalamocortical synapse of the visual system has been central to our understanding of sensory computations in the cortex. Although we have a fair understanding of the functional properties of the pre and post-synaptic populations, little is known about their synaptic properties, particularly in vivo. We used simultaneous recordings in LGN and V1 in cat in vivo to characterize the dynamic properties of thalamocortical synaptic transmission in monosynaptically connected LGN-V1 neurons. We found that thalamocortical synapses in vivo are unreliable, highly variable and exhibit short-term plasticity. Using biologically constrained models, we found that variable and unreliable synapses serve to increase cortical firing by means of increasing membrane fluctuations, similar to high conductance states. Thus, synaptic variability and unreliability, rather than acting as system noise, do serve a computational function. Our characterization of LGN-V1 synaptic properties constrains existing mathematical models, and mechanistic hypotheses, of a fundamental circuit in computational neuroscience.
Identifiants
pubmed: 31032799
doi: 10.7554/eLife.41925
pii: 41925
pmc: PMC6506206
doi:
pii:
Banques de données
Dryad
['10.5061/dryad.57pv818']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NEI NIH HHS
ID : P30 EY001583
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY027205
Pays : United States
Organisme : NIH HHS
ID : F32EY026463
Pays : United States
Organisme : NEI NIH HHS
ID : R01EY027205
Pays : United States
Informations de copyright
© 2019, Sedigh-Sarvestani et al.
Déclaration de conflit d'intérêts
MS, LP, DC No competing interests declared
Références
J Neurophysiol. 1998 Mar;79(3):1219-29
pubmed: 9497403
J Physiol. 1962 Jan;160:106-54
pubmed: 14449617
Nature. 1995 Nov 16;378(6554):281-4
pubmed: 7477347
Vision Res. 2007 Sep;47(19):2569-74
pubmed: 17688906
J Neurophysiol. 1969 Sep;32(5):727-42
pubmed: 4980023
J Neurophysiol. 2007 Nov;98(5):2647-63
pubmed: 17581854
J Neurosci. 2016 Nov 30;36(48):12144-12156
pubmed: 27903724
Cereb Cortex. 1998 Jul-Aug;8(5):462-76
pubmed: 9722089
Nature. 2014 May 8;509(7499):226-9
pubmed: 24695217
J Neurophysiol. 2012 Mar;107(5):1476-88
pubmed: 22090462
Nature. 1996 Jul 18;382(6588):258-61
pubmed: 8717041
J Neurophysiol. 2003 Aug;90(2):946-60
pubmed: 12711706
Trends Neurosci. 2010 Jun;33(6):259-66
pubmed: 20371122
J Neurosci. 2009 Jul 15;29(28):9127-36
pubmed: 19605650
Cell Rep. 2015 Dec 15;13(10):2098-106
pubmed: 26670044
J Neurosci. 2014 Nov 12;34(46):15455-65
pubmed: 25392512
J Neurosci. 2007 Sep 26;27(39):10333-44
pubmed: 17898205
J Neurosci. 2011 Feb 23;31(8):2925-37
pubmed: 21414914
Eur J Pharmacol. 1992 Jul 21;218(1):59-68
pubmed: 1383009
Neuroscience. 2001;107(1):13-24
pubmed: 11744242
Elife. 2019 Apr 29;8:
pubmed: 31032799
J Neurosci. 2000 Jul 15;20(14):5392-400
pubmed: 10884324
Nat Rev Neurosci. 2003 Sep;4(9):739-51
pubmed: 12951566
Nat Neurosci. 2007 Apr;10(4):462-8
pubmed: 17334362
Curr Biol. 2015 Mar 16;25(6):722-731
pubmed: 25728691
J Physiol. 1968 Mar;195(1):215-43
pubmed: 4966457
J Neurosci. 2017 May 24;37(21):5250-5262
pubmed: 28438969
Neuron. 1998 Jun;20(6):1177-89
pubmed: 9655505
J Physiol. 1966 Dec;187(3):517-52
pubmed: 16783910
J Neurosci. 2016 Jun 29;36(26):6906-16
pubmed: 27358449
Science. 2006 Jun 16;312(5780):1622-7
pubmed: 16778049
J Neurosci. 2003 Jul 30;23(17):6936-45
pubmed: 12890788
J Physiol. 2006 Sep 1;575(Pt 2):583-602
pubmed: 16793907
J Comp Neurol. 2009 Oct 1;516(4):264-76
pubmed: 19634180
Philos Trans R Soc Lond B Biol Sci. 2002 Dec 29;357(1428):1793-808
pubmed: 12626013
Nat Rev Neurosci. 2009 May;10(5):373-83
pubmed: 19377502
J Neurosci. 2014 May 14;34(20):6746-58
pubmed: 24828630
Science. 1993 Oct 29;262(5134):679-85
pubmed: 8235588
Nature. 2018 Jun;558(7711):590-594
pubmed: 29925954
Cold Spring Harb Perspect Biol. 2012 Jul 01;4(7):a005702
pubmed: 22751149
J Physiol. 1954 Jun 28;124(3):560-73
pubmed: 13175199
J Neurophysiol. 2001 Dec;86(6):2789-806
pubmed: 11731537
J Neurophysiol. 2000 Sep;84(3):1488-96
pubmed: 10980021
Neuron. 2008 Jul 10;59(1):150-60
pubmed: 18614036
Nature. 1975 Dec 18;258(5536):625-7
pubmed: 1207741
Neuron. 2002 Aug 15;35(4):773-82
pubmed: 12194875
PLoS One. 2012;7(7):e40601
pubmed: 22848386
Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Jun;91(6):062707
pubmed: 26172736
J Neurophysiol. 1983 Jun;49(6):1303-18
pubmed: 6875624
Commun Integr Biol. 2011 Sep;4(5):543-8
pubmed: 22046457
Neuron. 2015 Jan 7;85(1):68-75
pubmed: 25543458
Neuroscience. 2005;131(1):1-11
pubmed: 15680687
Cold Spring Harb Symp Quant Biol. 1952;17:281-92
pubmed: 13049173
J Neurosci. 2005 Aug 3;25(31):7179-90
pubmed: 16079400
Nature. 2015 Feb 19;518(7539):399-403
pubmed: 25652823
J Physiol. 1999 Nov 15;521 Pt 1:169-90
pubmed: 10562343
Cereb Cortex. 1993 Jan-Feb;3(1):69-78
pubmed: 8439740
J Neurosci. 2010 Mar 10;30(10):3652-62
pubmed: 20219999