Inhibitory effects of homoharringtonine on foot and mouth disease virus in vitro.
FMDV
RNA virus
antiviral
homoharringtonine
viral replication
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
25
02
2019
revised:
20
04
2019
accepted:
22
04
2019
pubmed:
30
4
2019
medline:
4
6
2020
entrez:
30
4
2019
Statut:
ppublish
Résumé
Foot-and-mouth disease (FMD) is a highly contagious disease that affects cloven-hoof animals including cattle, swine, sheep, goats, and lots of wild species. Effectively control measures are urged needed. Here, we showed that homoharringtonine treatment exhibited a strong inhibitory effect against two different strains of FMDVs (O/MYA98/BY/2010 and A/GD/MM/2013) in swine kidney (IBRS-2) cells. Further experiments demonstrated that homoharringtonine did not affect virus attachment or entry. Using time-of-addition assays, we found that the antiviral activity of homoharringtonine occurred primarily during the early stage of infection. These results demonstrated that homoharringtonine might be an effective anti-FMDV drug. Further studies are required to explore the antiviral activity of homoharringtonine against FMDV replication in vivo.
Identifiants
pubmed: 31032977
doi: 10.1002/jmv.25494
pmc: PMC7166808
doi:
Substances chimiques
Antiviral Agents
0
Homoharringtonine
6FG8041S5B
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1595-1601Subventions
Organisme : National Key Research and Development Program
ID : 2017YFD0500902
Pays : International
Organisme : National Pig Industrial System of China
ID : CARS-36-06B
Pays : International
Organisme : Key R&D Program of Gansu Province of China
ID : 17YF1NA070
Pays : International
Organisme : National Natural Science Foundation of China
ID : 31760723
Pays : International
Organisme : National Natural Science Foundation of China
ID : 31260595
Pays : International
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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