Impact of Comorbidity on Physical Function in Patients With Ankylosing Spondylitis and Psoriatic Arthritis Attending Rheumatology Clinics: Results From a Cross-Sectional Study.
Journal
Arthritis care & research
ISSN: 2151-4658
Titre abrégé: Arthritis Care Res (Hoboken)
Pays: United States
ID NLM: 101518086
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
27
09
2018
accepted:
23
04
2019
pubmed:
30
4
2019
medline:
3
10
2020
entrez:
30
4
2019
Statut:
ppublish
Résumé
To evaluate the impact of comorbidities on physical function in patients with ankylosing spondylitis (AS) and psoriatic arthritis (PsA). This was a cross-sectional analysis of the baseline visit from the Cardiovascular in Rheumatology study. Multivariate models with physical function as the dependent variable (Bath Ankylosing Spondylitis Functional Index and Health Assessment Questionnaire for AS and PsA, respectively) were performed. Independent variables were a proxy for the Charlson Comorbidity Index (CCIp; range 0-27), sociodemographic data, disease activity (erythrocyte sedimentation rate [ESR] and Bath Ankylosing Spondylitis Disease Activity Index [BASDAI] in AS; Disease Activity Score in 28 joints [DAS28] using the ESR in PsA), disease duration, radiographic damage, and treatments. Results were reported as beta coefficients, 95% confidence intervals (95% CIs), and P values. We included 738 patients with AS and 721 with PsA; 21% of patients had >1 comorbidity. Comorbidity burden (CCIp) was independently associated with worse adjusted physical function in patients with PsA (β = 0.11). Also, female sex (β = 0.14), disease duration (β = 0.01), disease activity (DAS28-ESR; β = 0.19), and the use of nonsteroidal antiinflammatory drugs (β = 0.09), glucocorticoids (β = 0.11), and biologics (β = 0.15) were associated with worse function in patients with PsA. A higher education level was associated with less disability (β = -0.14). In patients with AS, age (β = 0.03), disease activity (BASDAI; β = 0.81), radiographic damage (β = 0.61), and the use of biologics (β = 0.51) were independently associated with worse function on multivariate analyses, but CCIp was not. The presence of comorbidities in patients with PsA is independently associated with worse physical function. The detection and control of the comorbidities may yield an integral management of the disease.
Identifiants
pubmed: 31033231
doi: 10.1002/acr.23910
pmc: PMC7318148
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
822-828Investigateurs
Eugenia Gonzalez de Rabago
(E)
Elena Alonso Blanco Morales
(EA)
J Carlos Fernández Lopez
(JC)
Natividad Oreiro Villar
(N)
Antonio Atanes Sandoval
(A)
Francisco J Blanco García
(FJ)
Cayetano Alegre De Miquel
(C)
María J González Fernández
(MJ)
Ramón Huguet Codina
(RH)
Beatriz Yoldi
(B)
Mercedes Ramentol
(M)
Gabriela Ávila
(G)
Sara Marsal Barril
(S)
Martina Steiner
(M)
Santiago Muñoz
(S)
Fernando Gamero
(F)
José García Torón
(J)
Pilar Espino
(P)
Inmaculada Ros
(I)
Mónica Ibáñez
(M)
Claudia Murillo
(C)
Jesús Tornero Molina
(JT)
Raimon Sanmartí
(R)
Horacio Berman
(H)
Sonia Cabrera
(S)
Virginia Ruiz
(V)
Oscar Fontseré Patón
(OF)
Benjamín Fernández Gutierrez
(B)
Lydia Abasolo
(L)
Jose Manuel Pina
(JM)
Joan M Nolla
(JM)
Miriam García Arias
(M)
Mirem Uriarte-Ecenarro
(M)
Jesús A García Vadillo
(JA)
Antonio Fernández Nebro
(A)
Sara Manrique Arija
(S)
María Angeles Belmonte López
(MA)
Inmaculada Ureña
(I)
María V Irigoyen
(MV)
Virginia Coret Cagigal
(VC)
Daniel Pielfort Garrido
(DP)
Angel María García Aparicio
(AM)
Rebeca Belmonte Gómez
(R)
Pastora Granados Bautista
(PG)
Azucena Hernandez Sanz
(A)
Francisco J Manero
(FJ)
Fernando Jimenez Zorzo
(F)
Eugenio Giménez Ubeda
(E)
Jesús Marzo Gracía
(JM)
Chesús Beltrán Audera
(CB)
Marta Medrano
(M)
Ángela Pecondón
(Á)
Soledad Ojeda
(S)
Juan Carlos Quevedo
(JC)
Félix Francisco
(F)
Carlos Rodríguez Lozano
(C)
Delia Gerona
(D)
Carlos González Fernández
(C)
Luis Carreño
(L)
Indalecio Monteagudo
(I)
Javier Del Pino
(J)
María Enriqueta Peiró
(ME)
Cristina Fernández-Carballido
(C)
José M Senabre
(JM)
José C Rosas
(JC)
Isabel Rotés
(I)
Estefanía Moreno
(E)
Alba Erra
(A)
Dolors Grado
(D)
Javier Calvo
(J)
Amalia Rueda
(A)
Ingrid Möller
(I)
Isabel Rodríguez
(I)
Enrique Raya
(E)
Pilar Morales
(P)
Ana Nieto
(A)
Inmaculada Jiménez
(I)
Cesar Magro
(C)
Ana Ruibal Escribano
(A)
Sergio Ros Expósito
(SR)
Ginés Sánchez Nievas
(G)
Enrique Júdez Navarro
(EJ)
Manuela Sianes Fernández
(M)
María Angeles García Morales
(MA)
Isabel Labiano Bastero
(IL)
Gloria García Consuegra
(GG)
Natalia Palmou
(N)
Silvia Martínez Pardo
(SM)
Manel Pujol
(M)
Elena Riera Alonso
(ER)
Georgina Salvador
(G)
Beatriz González Alvarez
(B)
Alberto Cantabrana
(A)
Sagrario Bustabad
(S)
Esmeralda Delgado
(E)
Alejandro Muñoz
(A)
Sergio Rodriguez Montero
(SR)
Luis María Jimenez
(LM)
Informations de copyright
© 2020 The Authors. Arthritis Care & Research published by Wiley Periodicals, Inc. on behalf of American College of Rheumatology.
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