Reducing Hematologic Toxicity With Short Course Postexposure Prophylaxis With Zidovudine for HIV-1 Exposed Infants With Low Transmission Risk.


Journal

The Pediatric infectious disease journal
ISSN: 1532-0987
Titre abrégé: Pediatr Infect Dis J
Pays: United States
ID NLM: 8701858

Informations de publication

Date de publication:
07 2019
Historique:
pubmed: 30 4 2019
medline: 23 4 2020
entrez: 30 4 2019
Statut: ppublish

Résumé

Using retrospectively collected data from 383 infants born to HIV-1-infected mothers receiving antiretroviral therapy, we compared transmission rates and hematologic toxicity between infants receiving 2-week (short course) versus longer duration zidovudine postexposure prophylaxis. Short course resulted in lower hematologic toxicity without evidence of increased vertical transmission risk.

Identifiants

pubmed: 31033907
doi: 10.1097/INF.0000000000002357
doi:

Substances chimiques

Anti-HIV Agents 0
Zidovudine 4B9XT59T7S

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

727-730

Auteurs

Thi Thanh Truc Nguyen (TTT)

From the Department of Paediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Robin Kobbe (R)

From the Department of Paediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Ulf Schulze-Sturm (U)

From the Department of Paediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Martin Blohm (M)

From the Department of Paediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Bettina Hollwitz (B)

Department of Obstetrics and Prenatal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Sandra Hertling (S)

First Department of Medicine, Infectious Diseases Unit, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Christina Becker (C)

Department of Paediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Heinrich Heine University, Düsseldorf, Germany.

Prasad Thomas Oommen (PT)

Department of Paediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Heinrich Heine University, Düsseldorf, Germany.

Hans-Jürgen Laws (HJ)

Department of Paediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Heinrich Heine University, Düsseldorf, Germany.

Franca Martignoni (F)

Department of Obstetrics and Gynaecology, Heinrich Heine University, Düsseldorf, Germany.

Björn-Erik Ole Jensen (BE)

Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University, Düsseldorf, Germany.

Karen Olah (K)

Ifi-Institute for Interdisciplinary Medicine, Hamburg, Germany.

Susanne Schmidtke (S)

Neonatology Unit at Asclepios Hospital Hamburg-Barmbek, Hamburg, Germany.

Benno Kreuels (B)

Infectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine (BNITM), Hamburg, Germany.

Malte Kohns Vasconcelos (MK)

Paediatric Infectious Diseases Research Group, Institute for Infection and Immunity, St. George's, University of London, United Kingdom.

Jennifer Neubert (J)

Department of Paediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Heinrich Heine University, Düsseldorf, Germany.

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Classifications MeSH