Lewis Acid Directed Regioselective Metalations of Pyridazine.
TMP bases
frustrated Lewis pairs
magnesiation
pyridazine
zincation
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
01 07 2019
01 07 2019
Historique:
received:
29
03
2019
pubmed:
30
4
2019
medline:
30
4
2019
entrez:
30
4
2019
Statut:
ppublish
Résumé
Mono- or bidentate boron Lewis acids trigger a regioselective magnesiation or zincation of pyridazine in position C3 (ortho product) or C4 (meta product). The regioselectivity of the metalation was rationalized with the help of calculated pK
Identifiants
pubmed: 31034125
doi: 10.1002/anie.201903839
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9244-9247Informations de copyright
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.