Viral modulation of cellular RNA alternative splicing: A new key player in virus-host interactions?
RNA alternative splicing
virus
virus-host interactions
Journal
Wiley interdisciplinary reviews. RNA
ISSN: 1757-7012
Titre abrégé: Wiley Interdiscip Rev RNA
Pays: United States
ID NLM: 101536955
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
13
12
2018
revised:
25
03
2019
accepted:
08
04
2019
pubmed:
30
4
2019
medline:
15
7
2020
entrez:
30
4
2019
Statut:
ppublish
Résumé
Upon viral infection, a tug of war is triggered between host cells and viruses to maintain/gain control of vital cellular functions, the result of which will ultimately dictate the fate of the host cell. Among these essential cellular functions, alternative splicing (AS) is an important RNA maturation step that allows exons, or parts of exons, and introns to be retained in mature transcripts, thereby expanding proteome diversity and function. AS is widespread in higher eukaryotes, as it is estimated that nearly all genes in humans are alternatively spliced. Recent evidence has shown that upon infection by numerous viruses, the AS landscape of host-cells is affected. In this review, we summarize recent advances in our understanding of how virus infection impacts the AS of cellular transcripts. We also present various molecular mechanisms allowing viruses to modulate cellular AS. Finally, the functional consequences of these changes in the RNA splicing signatures during virus-host interactions are discussed. This article is categorized under: RNA in Disease and Development > RNA in Disease RNA Processing > Splicing Regulation/Alternative Splicing.
Identifiants
pubmed: 31034770
doi: 10.1002/wrna.1543
pmc: PMC6767064
doi:
Substances chimiques
RNA, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1543Subventions
Organisme : CIHR
Pays : Canada
Informations de copyright
© 2019 The Authors. WIREs RNA published by Wiley Periodicals, Inc.
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