Impact of Extrinsic and Intrinsic Hypoxia on Catecholamine Biosynthesis in Absence or Presence of Hif2α in Pheochromocytoma Cells.

EPAS1 HIF catecholamine hypoxia pheochromocytoma and paraganglioma phosphorylation tyrosine hydroxylase pseudohypoxia spheroids

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
28 Apr 2019
Historique:
received: 26 03 2019
revised: 24 04 2019
accepted: 25 04 2019
entrez: 1 5 2019
pubmed: 1 5 2019
medline: 1 5 2019
Statut: epublish

Résumé

Pheochromocytomas and paragangliomas (PPGLs) with activated pseudohypoxic pathways are associated with an immature catecholamine phenotype and carry a higher risk for metastasis. For improved understanding of the underlying mechanisms we investigated the impact of hypoxia and pseudohypoxia on catecholamine biosynthesis in pheochromocytoma cells naturally lacking

Identifiants

DOI: 10.3390/cancers11050594 PMID: 31035382 PMC: PMC6562431
pubmed: 31035382
pii: cancers11050594
doi: 10.3390/cancers11050594
pmc: PMC6562431
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : 314061271-TRR 205
Organisme : Paradifference Foundation
ID : 1

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Auteurs

Nicole Bechmann (N)

Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany. Nicole.bechmann@uniklinikum-dresden.de.
ORCID: 0000-0002-6932-333X

Isabel Poser (I)

Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany. Isabel.poser@uniklinikum-dresden.de.

Verena Seifert (V)

Department of Radiopharmaceutical and Chemical Biology, Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstrasse 400, 01328 Dresden, Germany. v.seifert@hzdr.de.

Christian Greunke (C)

Research Unit Analytical Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany; Ingolstädter Landstraße 1, 85764 Neuherberg, Germany. christian.greunke@gmx.de.
ORCID: 0000-0001-7787-4281

Martin Ullrich (M)

Department of Radiopharmaceutical and Chemical Biology, Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstrasse 400, 01328 Dresden, Germany. m.ullrich@hzdr.de.
ORCID: 0000-0001-6104-6676

Nan Qin (N)

Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. nan.qin@med.uni-duesseldorf.de.
German Consortium for Translational Cancer Research (DKTK), partner site Essen/Düsseldorf, 45147 Düsseldorf, Germany. nan.qin@med.uni-duesseldorf.de.
Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, University Hospital Düsseldorf, 40225 Düsseldorf, Germany. nan.qin@med.uni-duesseldorf.de.
Department of Neuropathology, Medical Faculty, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany. nan.qin@med.uni-duesseldorf.de.

Axel Walch (A)

Research Unit Analytical Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany; Ingolstädter Landstraße 1, 85764 Neuherberg, Germany. axel.walch@helmholtz-muenchen.de.

Mirko Peitzsch (M)

Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany. Mirko.peitzsch@uniklinikum-dresden.de.

Mercedes Robledo (M)

Hereditary Endocrine Cancer Group, CNIO, Madrid, Spain and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), 28029 Madrid, Spain. mrobledo@cnio.es.

Karel Pacak (K)

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. karel@mail.nih.gov.

Jens Pietzsch (J)

Department of Radiopharmaceutical and Chemical Biology, Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstrasse 400, 01328 Dresden, Germany. j.pietzsch@hzdr.de.
Department of Chemistry and Food Chemistry, School of Science, Technische Universität Dresden, Mommsenstrasse 9, 01062 Dresden, Germany. j.pietzsch@hzdr.de.
ORCID: 0000-0002-1610-1493

Susan Richter (S)

Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany. susan.richter@uniklinikum-dresden.de.

Graeme Eisenhofer (G)

Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany. Graeme.eisenhofer@uniklinikum-dresden.de.
Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany. Graeme.eisenhofer@uniklinikum-dresden.de.

Classifications MeSH