Melatonin Levels in Preterm and Term Infants and Their Mothers.
brain development
melatonin
neuroprotection
prematurity
term infants
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Apr 2019
27 Apr 2019
Historique:
received:
25
03
2019
accepted:
23
04
2019
entrez:
1
5
2019
pubmed:
1
5
2019
medline:
17
8
2019
Statut:
epublish
Résumé
The prevention of perinatal brain damage following preterm birth remains a public health priority. Melatonin has been shown to be a promising neuroprotectant in neonatal preclinical models of brain damage, but few studies have investigated melatonin secretion in newborns. We hypothesized that melatonin circulating levels would be lower in preterm compared to term infants. We conducted a prospective, longitudinal, multicenter study to assess melatonin, and 6-sulfatoxy-melatonin (aMT6s) concentrations, measured by radioimmunoassay. Among 209 neonates recruited, 110 were born before 34 gestational weeks (GW) and 99 born after 34 GW. Plasma melatonin concentrations, measured at birth and on Day 3 were below detectable levels (≤7 pg/mL) in 78% and 81%, respectively, of infants born before 34 GW compared to 57% and 34%, respectively, of infants born after 34 GW. The distribution of plasma melatonin concentrations was found to be correlated with gestational age at both time-points (
Identifiants
pubmed: 31035572
pii: ijms20092077
doi: 10.3390/ijms20092077
pmc: PMC6540351
pii:
doi:
Substances chimiques
Biomarkers
0
6-sulfatoxymelatonin
2208-40-4
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : research grant from the French Ministry of Health and sponsored by the Délégation à la Recherche Clinique et à l'Innovation, Assistance Publique-Hôpitaux de Paris
ID : AOR10024
Références
Toxicol Sci. 1999 Aug;50(2):271-9
pubmed: 10478864
Semin Perinatol. 2000 Aug;24(4):258-66
pubmed: 10975432
J Biomed Sci. 2000 Nov-Dec;7(6):444-58
pubmed: 11060493
J Pineal Res. 2001 Jan;30(1):29-33
pubmed: 11168904
J Pineal Res. 2001 Jan;30(1):34-42
pubmed: 11168905
J Pineal Res. 2001 Nov;31(4):343-9
pubmed: 11703564
Pediatr Res. 2001 Dec;50(6):756-60
pubmed: 11726736
J Pineal Res. 1992 Nov;13(4):184-91
pubmed: 1287194
J Pediatr Surg. 2004 Feb;39(2):184-9; discussion 184-9
pubmed: 14966737
Sleep Med Rev. 2005 Feb;9(1):11-24
pubmed: 15649735
J Pineal Res. 2005 Oct;39(3):287-93
pubmed: 16150110
J Clin Endocrinol Metab. 1992 Aug;75(2):367-9
pubmed: 1639937
J Pineal Res. 2007 Jan;42(1):22-7
pubmed: 17198535
Neonatology. 2007;92(3):209-16
pubmed: 17519530
Reprod Toxicol. 2008 Apr;25(3):291-303
pubmed: 18485664
Pharmacol Rep. 2009 May-Jun;61(3):383-410
pubmed: 19605939
Clin Chem. 1991 Apr;37(4):536-9
pubmed: 2015667
Br J Clin Pharmacol. 2013 Nov;76(5):725-33
pubmed: 23432339
Dev Med Child Neurol. 2014 Aug;56(8):717-23
pubmed: 24575840
J Pineal Res. 2015 Aug;59(1):38-46
pubmed: 25833399
J Hum Lact. 2016 Nov;32(4):NP105-NP110
pubmed: 27121237
Early Hum Dev. 2016 Nov;102:1-3
pubmed: 27616207
Clin Chem Lab Med. 2017 Aug 28;55(9):1340-1348
pubmed: 27997348
Molecules. 2017 Dec 01;22(12):null
pubmed: 29194416
Clin Chem. 1987 Aug;33(8):1343-8
pubmed: 3608151
Biol Psychiatry. 1984 Aug;19(8):1215-28
pubmed: 6498244
J Reprod Fertil Suppl. 1995;49:423-35
pubmed: 7623332
Eur J Endocrinol. 1996 Aug;135(2):184-7
pubmed: 8810730
Dev Med Child Neurol. 1997 May;39(5):319-25
pubmed: 9236698