Phosphatidylinositol 5 Phosphate (PI5P): From Behind the Scenes to the Front (Nuclear) Stage.
Animals
Cell Nucleus
/ metabolism
Humans
Lipid Metabolism
Nuclear Proteins
/ metabolism
Phosphatidylinositol Phosphates
/ metabolism
Phosphotransferases (Alcohol Group Acceptor)
/ metabolism
Reactive Oxygen Species
/ metabolism
Receptors, Cytoplasmic and Nuclear
/ metabolism
Signal Transduction
Stress, Physiological
PI5P
PI5P4K/PIP4K
PIKFyve
myotubularin
nucleus
phosphatases
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Apr 2019
27 Apr 2019
Historique:
received:
31
03
2019
revised:
20
04
2019
accepted:
23
04
2019
entrez:
1
5
2019
pubmed:
1
5
2019
medline:
17
8
2019
Statut:
epublish
Résumé
Phosphatidylinositol (PI)-related signaling plays a pivotal role in many cellular aspects, including survival, cell proliferation, differentiation, DNA damage, and trafficking. PI is the core of a network of proteins represented by kinases, phosphatases, and lipases which are able to add, remove or hydrolyze PI, leading to different phosphoinositide products. Among the seven known phosphoinositides, phosphatidylinositol 5 phosphate (PI5P) was the last to be discovered. PI5P presence in cells is very low compared to other PIs. However, much evidence collected throughout the years has described the role of this mono-phosphoinositide in cell cycles, stress response, T-cell activation, and chromatin remodeling. Interestingly, PI5P has been found in different cellular compartments, including the nucleus. Here, we will review the nuclear role of PI5P, describing how it is synthesized and regulated, and how changes in the levels of this rare phosphoinositide can lead to different nuclear outputs.
Identifiants
pubmed: 31035587
pii: ijms20092080
doi: 10.3390/ijms20092080
pmc: PMC6539119
pii:
doi:
Substances chimiques
Nuclear Proteins
0
Phosphatidylinositol Phosphates
0
Reactive Oxygen Species
0
Receptors, Cytoplasmic and Nuclear
0
phosphatidylinositol 5-phosphate
0
Phosphotransferases (Alcohol Group Acceptor)
EC 2.7.1.-
Types de publication
Journal Article
Review
Langues
eng
Références
J Biol Chem. 1999 Jul 30;274(31):21589-97
pubmed: 10419465
FEBS Lett. 2000 Jun 9;475(1):57-60
pubmed: 10854858
Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8910-5
pubmed: 10900271
Hum Mol Genet. 2000 Sep 22;9(15):2223-9
pubmed: 11001925
Trends Biochem Sci. 2000 Oct;25(10):483-5
pubmed: 11050430
Biochemistry. 2000 Dec 26;39(51):15980-9
pubmed: 11123925
Exp Cell Res. 2001 Mar 10;264(1):29-41
pubmed: 11237521
J Biol Chem. 2002 Feb 8;277(6):4526-31
pubmed: 11733541
Chem Rev. 2001 Aug;101(8):2353-64
pubmed: 11749377
J Biol Chem. 2002 Dec 6;277(49):47276-84
pubmed: 12270933
EMBO J. 2002 Oct 1;21(19):5069-78
pubmed: 12356723
Curr Biol. 2003 Mar 18;13(6):504-9
pubmed: 12646134
Curr Biol. 2003 Apr 15;13(8):627-37
pubmed: 12699618
Nat Rev Mol Cell Biol. 2003 May;4(5):349-60
pubmed: 12728269
Plant Physiol. 2003 Jun;132(2):461-8
pubmed: 12805579
Cell. 2003 Jul 11;114(1):99-111
pubmed: 12859901
J Biol Chem. 1992 Mar 15;267(8):5078-84
pubmed: 1312084
Mol Cell. 2003 Dec;12(6):1391-402
pubmed: 14690594
J Biol Chem. 2004 Nov 12;279(46):48350-9
pubmed: 15339928
Genes Dev. 2005 Mar 1;19(5):553-69
pubmed: 15706034
Int J Biochem Cell Biol. 2005 May;37(5):1054-65
pubmed: 15743678
Curr Opin Struct Biol. 2005 Dec;15(6):614-20
pubmed: 16289848
Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18854-9
pubmed: 16365287
Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):927-32
pubmed: 16410353
EMBO J. 1991 Nov;10(11):3207-14
pubmed: 1655412
Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):6049-54
pubmed: 16585509
Nature. 2006 Jul 6;442(7098):96-9
pubmed: 16728974
Nucleic Acids Res. 2006 Jul 04;34(11):3288-98
pubmed: 16820529
Crit Rev Biochem Mol Biol. 2006 May-Jun;41(3):105-78
pubmed: 16858867
Mol Cell. 2006 Sep 1;23(5):685-95
pubmed: 16949365
Nature. 2006 Oct 12;443(7112):651-7
pubmed: 17035995
Biochem Soc Symp. 2007;(74):117-28
pubmed: 17233585
J Gen Physiol. 2007 Apr;129(4):267-83
pubmed: 17389247
Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16834-9
pubmed: 17940011
Biochem J. 2008 Jan 1;409(1):1-18
pubmed: 18062770
Nat Rev Mol Cell Biol. 2008 Feb;9(2):112-24
pubmed: 18216768
Nat Rev Mol Cell Biol. 2008 Feb;9(2):162-76
pubmed: 18216772
J Biol Chem. 2008 Mar 28;283(13):8678-86
pubmed: 18218622
Curr Genomics. 2006;7(8):509-22
pubmed: 18369404
BMB Rep. 2008 Jun 30;41(6):415-34
pubmed: 18593525
Adv Enzyme Regul. 1991;31:399-416
pubmed: 1877396
Mol Cell. 2008 Oct 10;32(1):96-105
pubmed: 18851836
Mol Cell Biol. 2009 Jan;29(2):342-56
pubmed: 19015240
J Cell Sci. 2009 Nov 1;122(Pt 21):3837-50
pubmed: 19889969
Nutr Res Pract. 2007 Spring;1(1):29-35
pubmed: 20535382
J Oncol. 2011;2011:963614
pubmed: 21052543
Cell Res. 2011 Mar;21(3):381-95
pubmed: 21321607
Microbiol Mol Biol Rev. 2011 Mar;75(1):50-83
pubmed: 21372320
J Cell Biochem. 2011 Sep;112(9):2203-9
pubmed: 21503961
Pflugers Arch. 2011 Nov;462(5):723-32
pubmed: 21847559
Handb Exp Pharmacol. 2011;206:13-37
pubmed: 21879444
PLoS Genet. 2011 Oct;7(10):e1002319
pubmed: 22028665
Plant J. 2012 Jun;70(5):866-78
pubmed: 22324391
Nat Rev Genet. 2012 Apr 03;13(5):343-57
pubmed: 22473383
Am J Physiol Cell Physiol. 2012 Aug 15;303(4):C436-46
pubmed: 22621786
Curr Top Microbiol Immunol. 2012;362:127-62
pubmed: 23086417
EMBO Rep. 2013 Jan;14(1):57-64
pubmed: 23154468
Sci Signal. 2012 Nov 27;5(252):ra86
pubmed: 23193159
Front Immunol. 2013 Apr 02;4:80
pubmed: 23565114
Adv Biol Regul. 2013 May;53(2):179-89
pubmed: 23602596
Biochem J. 2013 Aug 15;454(1):49-57
pubmed: 23758345
Sci Rep. 2013;3:2137
pubmed: 23823870
Cell Host Microbe. 2013 Aug 14;14(2):148-58
pubmed: 23954154
Cancer Res. 2013 Dec 1;73(23):6913-25
pubmed: 24127122
Cell. 2013 Nov 7;155(4):844-57
pubmed: 24209622
Chem Soc Rev. 2014 May 21;43(10):3426-52
pubmed: 24549396
Oncogene. 2015 Mar 5;34(10):1253-1262
pubmed: 24681948
Mol Cell. 2014 Jun 19;54(6):905-19
pubmed: 24813945
Nat Commun. 2014 Jun 06;5:4080
pubmed: 24905281
Mol Cell. 2014 Jun 19;54(6):901-3
pubmed: 24950375
Adv Biol Regul. 2015 Jan;57:193-202
pubmed: 25311266
Clin Exp Pharmacol Physiol. 2015 Feb;42(2):117-24
pubmed: 25377120
Bioessays. 2015 Mar;37(3):267-77
pubmed: 25404370
Nature. 1989 Sep 21;341(6239):197-205
pubmed: 2550825
Biochim Biophys Acta. 2015 Jun;1851(6):898-910
pubmed: 25728392
Mol Cell. 2015 May 7;58(3):453-67
pubmed: 25866244
J Cell Physiol. 2016 Aug;231(8):1645-55
pubmed: 26626942
Mol Cell. 2016 Jan 21;61(2):187-98
pubmed: 26774281
Cell Rep. 2016 Feb 2;14(4):750-759
pubmed: 26776508
Chem Rev. 2016 Mar 9;116(5):3029-85
pubmed: 26875845
Nat Commun. 2016 Apr 05;7:11197
pubmed: 27045799
Trends Biochem Sci. 2016 Jun;41(6):473-475
pubmed: 27132569
J Membr Biol. 2017 Aug;250(4):353-366
pubmed: 27278236
Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7596-601
pubmed: 27313209
Cell Rep. 2017 Feb 14;18(7):1713-1726
pubmed: 28199843
Tumour Biol. 2017 Feb;39(2):1010428317692205
pubmed: 28218043
Biochem J. 1987 Dec 15;248(3):765-70
pubmed: 2829840
Cell Struct Funct. 2017 May 3;42(1):49-60
pubmed: 28302928
Elife. 2017 Dec 26;6:
pubmed: 29256861
Mol Cell. 2018 May 3;70(3):531-544.e9
pubmed: 29727621
Mol Cell. 2018 Sep 6;71(5):653-673
pubmed: 30193094
Biochem J. 2019 Jan 7;476(1):1-23
pubmed: 30617162
J Biol Chem. 1983 Aug 10;258(15):9368-73
pubmed: 6308005
Biochem J. 1995 Nov 15;312 ( Pt 1):63-7
pubmed: 7492336
Cell. 1993 Aug 13;74(3):405-7
pubmed: 8394217
Annu Rev Biochem. 1996;65:769-99
pubmed: 8811195
Biochem J. 1997 Oct 15;327 ( Pt 2):569-76
pubmed: 9359431
Nature. 1997 Nov 13;390(6656):192-6
pubmed: 9367159
FEBS Lett. 1997 Nov 24;418(1-2):23-6
pubmed: 9414087
Cell. 1998 Sep 18;94(6):829-39
pubmed: 9753329
Mol Cell Biol. 1999 Jan;19(1):623-34
pubmed: 9858586