Filling the Gap: Neural Stem Cells as A Promising Therapy for Spinal Cord Injury.
cell-based therapies
clinical trials
induced pluripotent stem cells
neural stem cells
spinal cord injury
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
29 Apr 2019
29 Apr 2019
Historique:
received:
12
03
2019
revised:
15
04
2019
accepted:
23
04
2019
entrez:
1
5
2019
pubmed:
1
5
2019
medline:
1
5
2019
Statut:
epublish
Résumé
Spinal cord injury (SCI) can lead to severe motor, sensory and social impairments having a huge impact on patients' lives. The complex and time-dependent SCI pathophysiology has been hampering the development of novel and effective therapies. Current treatment options include surgical interventions, to stabilize and decompress the spinal cord, and rehabilitative care, without providing a cure for these patients. Novel therapies have been developed targeting different stages during trauma. Among them, cell-based therapies hold great potential for tissue regeneration after injury. Neural stem cells (NSCs), which are multipotent cells with inherent differentiation capabilities committed to the neuronal lineage, are especially relevant to promote and reestablish the damaged neuronal spinal tracts. Several studies demonstrate the regenerative effects of NSCs in SCI after transplantation by providing neurotrophic support and restoring synaptic connectivity. Therefore, human clinical trials have already been launched to assess safety in SCI patients. Here, we review NSC-based experimental studies in a SCI context and how are they currently being translated into human clinical trials.
Identifiants
pubmed: 31035689
pii: ph12020065
doi: 10.3390/ph12020065
pmc: PMC6631328
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Fundação para a Ciência e a Tecnologia
ID : PTDC/DTP-FTO/5109/2014
Organisme : European Regional Development Fund
ID : NORTE-01-0145-FEDER-000013
Organisme : European Regional Development Fund
ID : NORTE-01-0145-FEDER-029968
Organisme : European Regional Development Fund
ID : POCI-01-0145-FEDER-007038
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