Clinical neurophysiology of migraine with aura.
Cortical excitability
Habituation
Interhemispheric asymmetry
Neuromodulation
Paradoxical responses
Slow rhythms
Journal
The journal of headache and pain
ISSN: 1129-2377
Titre abrégé: J Headache Pain
Pays: England
ID NLM: 100940562
Informations de publication
Date de publication:
29 Apr 2019
29 Apr 2019
Historique:
received:
19
02
2019
accepted:
16
04
2019
entrez:
1
5
2019
pubmed:
1
5
2019
medline:
19
7
2019
Statut:
epublish
Résumé
The purpose of this review is to provide a comprehensive overview of the findings of clinical electrophysiology studies aimed to investigate changes in information processing of migraine with aura patients. Abnormalities in alpha rhythm power and symmetry, the presence of slowing, and increased information flow in a wide range of frequency bands often characterize the spontaneous EEG activity of MA. Higher grand-average cortical response amplitudes, an increased interhemispheric response asymmetry, and lack of amplitude habituation were less consistently demonstrated in response to any kind of sensory stimulation in MA patients. Studies with single-pulse and repetitive transcranial magnetic stimulation (TMS) have reported abnormal cortical responsivity manifesting as greater motor evoked potential (MEP) amplitude, lower threshold for phosphenes production, and paradoxical effects in response to both depressing or enhancing repetitive TMS methodologies. Studies of the trigeminal system in MA are sparse and the few available showed lack of blink reflex habituation and abnormal findings on SFEMG reflecting subclinical, probably inherited, dysfunctions of neuromuscular transmission. The limited studies that were able to investigate patients during the aura revealed suppression of evoked potentials, desynchronization in extrastriate areas and in the temporal lobe, and large variations in direct current potentials with magnetoelectroencephalography. Contrary to what has been observed in the most common forms of migraine, patients with familial hemiplegic migraine show greater habituation in response to visual and trigeminal stimuli, as well as a higher motor threshold and a lower MEP amplitude than healthy subjects. Since most of the electrophysiological abnormalities mentioned above were more frequently present and had a greater amplitude in migraine with aura than in migraine without aura, neurophysiological techniques have been shown to be of great help in the search for the pathophysiological basis of migraine aura.
Sections du résumé
BACKGROUND
BACKGROUND
The purpose of this review is to provide a comprehensive overview of the findings of clinical electrophysiology studies aimed to investigate changes in information processing of migraine with aura patients.
MAIN BODY
METHODS
Abnormalities in alpha rhythm power and symmetry, the presence of slowing, and increased information flow in a wide range of frequency bands often characterize the spontaneous EEG activity of MA. Higher grand-average cortical response amplitudes, an increased interhemispheric response asymmetry, and lack of amplitude habituation were less consistently demonstrated in response to any kind of sensory stimulation in MA patients. Studies with single-pulse and repetitive transcranial magnetic stimulation (TMS) have reported abnormal cortical responsivity manifesting as greater motor evoked potential (MEP) amplitude, lower threshold for phosphenes production, and paradoxical effects in response to both depressing or enhancing repetitive TMS methodologies. Studies of the trigeminal system in MA are sparse and the few available showed lack of blink reflex habituation and abnormal findings on SFEMG reflecting subclinical, probably inherited, dysfunctions of neuromuscular transmission. The limited studies that were able to investigate patients during the aura revealed suppression of evoked potentials, desynchronization in extrastriate areas and in the temporal lobe, and large variations in direct current potentials with magnetoelectroencephalography. Contrary to what has been observed in the most common forms of migraine, patients with familial hemiplegic migraine show greater habituation in response to visual and trigeminal stimuli, as well as a higher motor threshold and a lower MEP amplitude than healthy subjects.
CONCLUSION
CONCLUSIONS
Since most of the electrophysiological abnormalities mentioned above were more frequently present and had a greater amplitude in migraine with aura than in migraine without aura, neurophysiological techniques have been shown to be of great help in the search for the pathophysiological basis of migraine aura.
Identifiants
pubmed: 31035929
doi: 10.1186/s10194-019-0997-9
pii: 10.1186/s10194-019-0997-9
pmc: PMC6734510
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
42Références
Cephalalgia. 2018 Jan;38(1):1-211
pubmed: 29368949
Eur J Neurol. 1995 Apr;2(2):115-22
pubmed: 24283611
Clin Neurophysiol. 2003 Nov;114(11):2132-7
pubmed: 14580611
Eur J Neurol. 2011 Mar;18(3):478-85
pubmed: 20727009
Exp Brain Res. 2002 Jul;145(2):177-81
pubmed: 12110957
Headache. 1991 Apr;31(4):232-6
pubmed: 2050517
Lancet. 1961 Nov 11;2(7211):1057-9
pubmed: 13868977
Funct Neurol. 1997 Mar-Apr;12(2):77-82
pubmed: 9238341
Nat Rev Neurol. 2013 Nov;9(11):637-44
pubmed: 24042483
Brain. 2014 Jan;137(Pt 1):232-41
pubmed: 24277718
Brain. 2017 Jun 1;140(6):1633-1642
pubmed: 28430860
Cephalalgia. 2005 Oct;25(10):817-21
pubmed: 16162259
Headache. 2001 Jun;41(6):565-72
pubmed: 11437892
Clin Neurophysiol. 2014 Jun;125(6):1223-30
pubmed: 24332446
Brain. 2002 Apr;125(Pt 4):912-22
pubmed: 11912123
Electroencephalogr Clin Neurophysiol. 1967 Oct;23(4):381
pubmed: 4167778
Eur J Pain. 2011 Oct;15(9):928-35
pubmed: 21530338
Cephalalgia. 1990 Dec;10(6):279-84
pubmed: 2289228
Cephalalgia. 2003 Oct;23(8):814-9
pubmed: 14510928
Electroencephalogr Clin Neurophysiol. 1959 Aug;11(3):539-49
pubmed: 13663826
Cereb Cortex. 2012 Oct;22(10):2207-16
pubmed: 22079926
Cephalalgia. 2003 May;23(4):264-70
pubmed: 12716343
Neurology. 2001 Apr 24;56(8):1038-43
pubmed: 11320175
Nat Med. 2002 Feb;8(2):136-42
pubmed: 11821897
Brain. 1998 Feb;121 ( Pt 2):233-41
pubmed: 9549502
Cephalalgia. 2003 May;23(4):258-63
pubmed: 12716342
J Headache Pain. 2009 Oct;10(5):331-9
pubmed: 19705061
Clin Neurophysiol. 2005 Sep;116(9):2220-7
pubmed: 16043404
Headache. 2004 Mar;44(3):204-8
pubmed: 15012656
Arch Neurol. 1999 May;56(5):548-54
pubmed: 10328249
Neuropsychobiology. 2019;77(4):186-191
pubmed: 30544128
Clin Electroencephalogr. 1995 Jan;26(1):65-9
pubmed: 7882544
Cephalalgia. 2018 Mar;38(3):476-486
pubmed: 28952339
Neurophysiol Clin. 2017 Sep;47(4):269-274
pubmed: 28571630
Neurology. 1978 Aug;28(8):782-6
pubmed: 567295
Headache. 2005 May;45(5):546-52
pubmed: 15953273
N Engl J Med. 1994 Dec 22;331(25):1689-92
pubmed: 7969360
Cephalalgia. 2012 Sep;32(12):896-907
pubmed: 22800915
Brain. 2011 Aug;134(Pt 8):2387-95
pubmed: 21729907
Clin Neurophysiol. 2015 Oct;126(10):1988-93
pubmed: 25586129
Cephalalgia. 1994 Feb;14(1):41-6; discussion 4
pubmed: 8200025
Headache. 2017 Jun;57(6):887-898
pubmed: 28488755
Cephalalgia. 2007 Jul;27(7):833-9
pubmed: 17498207
J Neurol Neurosurg Psychiatry. 2000 Oct;69(4):507-11
pubmed: 10990512
Rev Electroencephalogr Neurophysiol Clin. 1987 Sep;17(3):289-99
pubmed: 3685574
Neurology. 1996 May;46(5):1404-9
pubmed: 8628490
Electroencephalogr Clin Neurophysiol. 1995 Jan;96(1):1-5
pubmed: 7530184
Lancet. 2001 Mar 31;357(9261):1016-7
pubmed: 11293599
BMJ Case Rep. 2013 Jun 10;2013:
pubmed: 23761507
Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4687-92
pubmed: 11287655
Cephalalgia. 1981 Jun;1(2):63-6
pubmed: 7346174
J Clin Neurosci. 2008 Aug;15(8):891-4
pubmed: 18313928
Acta Neurol Scand Suppl. 2009;(189):33-7
pubmed: 19566496
Neurol Sci. 2018 Jun;39(Suppl 1):69-71
pubmed: 29904856
Neuroreport. 2007 Mar 5;18(4):301-5
pubmed: 17435592
Headache. 1986 May;26(5):220-3
pubmed: 3721857
Clin Neurophysiol. 2016 Jan;127(1):810-816
pubmed: 26093935
Brain. 2005 Jan;128(Pt 1):98-103
pubmed: 15563513
Exp Brain Res. 2005 Feb;161(1):34-8
pubmed: 15480599
Headache. 2002 Jul-Aug;42(7):582-7
pubmed: 12482209
Pain. 2013 Sep;154(9):1738-1742
pubmed: 23693159
Eur J Ophthalmol. 2007 Sep-Oct;17(5):828-35
pubmed: 17932863
Neurology. 2002 Apr 9;58(7):1066-9
pubmed: 11940694
Headache. 1999 Jul-Aug;39(7):469-76
pubmed: 11279929
J Headache Pain. 2017 Sep 29;18(1):98
pubmed: 28963615
J Headache Pain. 2013 Feb 28;14:20
pubmed: 23565983
Cephalalgia. 2007 Dec;27(12):1360-7
pubmed: 17986271
Clin Neurophysiol. 2008 May;119(5):1020-7
pubmed: 18308628
Ann Neurol. 1990 Dec;28(6):791-8
pubmed: 2285266
PLoS Med. 2006 Oct;3(10):e402
pubmed: 17048979
Brain Res. 1999 Oct 2;843(1-2):71-8
pubmed: 10528112
Headache. 2015 Jun;55(6):794-805
pubmed: 26084236
Neurophysiol Clin. 2016 Nov;46(4-5):307-311
pubmed: 27155821
Ann Neurol. 1998 Aug;44(2):209-15
pubmed: 9708543
Cephalalgia. 1992 Aug;12(4):244-9; discussion 185-6
pubmed: 1525800
Neurol India. 2004 Mar;52(1):134
pubmed: 15069274
Cephalalgia. 2018 May;38(6):1167-1176
pubmed: 28856914
J Headache Pain. 2016;17:38
pubmed: 27090418
Headache. 2000 Jan;40(1):36-40
pubmed: 10759901
Eur J Paediatr Neurol. 1997;1(1):35-8
pubmed: 10728190
Hum Brain Mapp. 2014 Apr;35(4):1461-8
pubmed: 23450507
Headache. 2004 Feb;44(2):131-5
pubmed: 14756850
Front Cell Neurosci. 2016 Jun 13;10:156
pubmed: 27378853
Cephalalgia. 1998 Jul-Aug;18(6):319-23
pubmed: 9731935
Cephalalgia. 2005 Aug;25(8):567-74
pubmed: 16033381
J Neurol Sci. 2008 Aug 15;271(1-2):119-26
pubmed: 18495160
J Neurophysiol. 1947 Nov;10(6):409-14
pubmed: 20268874
Lancet Neurol. 2009 Aug;8(8):718-23
pubmed: 19570717
Lancet Neurol. 2015 Jan;14(1):65-80
pubmed: 25496898
Eur J Neurol. 2014 Feb;21(2):287-e13
pubmed: 24200371
Headache. 1990 Feb;30(3):129-32
pubmed: 2323913
Headache. 2005 Nov-Dec;45(10):1394-9
pubmed: 16324172
Cephalalgia. 2012 Oct;32(14):1041-8
pubmed: 22908362
Przegl Lek. 2010;67(9):688-91
pubmed: 21384789
Lancet. 1947 Jul 12;2(6463):52-4
pubmed: 20252058
Headache. 2011 May;51(5):726-33
pubmed: 21521207
Clin Electroencephalogr. 2000 Apr;31(2):83-7
pubmed: 10840630
Neurology. 1997 May;48(5):1462-4
pubmed: 9153495
J Neurol Sci. 1997 Feb 12;145(2):177-81
pubmed: 9094046
Headache. 1990 Feb;30(3):133-7
pubmed: 2323914
Headache. 1982 Mar;22(2):74-80
pubmed: 7085265
J Clin Neurophysiol. 2018 Jan;35(1):e3-e7
pubmed: 28445178
Neurology. 1995 Jan;45(1):33-7
pubmed: 7824130
Neurosci Lett. 1999 Dec 10;276(3):201-3
pubmed: 10612640
Electroencephalogr Clin Neurophysiol. 1998 Nov;107(5):374-8
pubmed: 9872440
Eur J Neurol. 2002 May;9(3):227-32
pubmed: 11985630
Clin Neurophysiol. 2000 Jun;111(6):1124-9
pubmed: 10825720
Cephalalgia. 2013 Apr;33(6):365-74
pubmed: 23359872
Neurology. 1978 Jun;28(6):584-8
pubmed: 565890
Nat Med. 1995 Jul;1(7):658-60
pubmed: 7585147
Neurosci Lett. 2009 Dec 18;467(1):26-9
pubmed: 19800389
Hum Brain Mapp. 2017 May;38(5):2635-2642
pubmed: 28240389
Cephalalgia. 1987 Mar;7(1):29-37
pubmed: 3581159
Pain. 2010 Jan;148(1):43-48
pubmed: 19854575
Neurology. 1998 Apr;50(4):1111-4
pubmed: 9566403
Acta Neurol Scand. 2001 Nov;104(5):301-7
pubmed: 11696025
Cephalalgia. 2013 Aug;33(11):938-47
pubmed: 23439574
Cephalalgia. 2016 Feb;36(2):139-47
pubmed: 25926619
Brain. 1999 Jun;122 ( Pt 6):1147-55
pubmed: 10356066
Acta Neurol Belg. 2001 Sep;101(3):166-70
pubmed: 11817265
Cephalalgia. 1986 Jun;6(2):95-100
pubmed: 3742594
Trends Neurosci. 2005 Jun;28(6):325-33
pubmed: 15927689
Cephalalgia. 1997 Nov;17(7):742-7
pubmed: 9399003
Cephalalgia. 2003 Mar;23(2):75-8
pubmed: 12603362
Arch Neurol. 2005 Aug;62(8):1270-5
pubmed: 16087768
Headache. 2013 Jul-Aug;53(7):1071-86
pubmed: 23298223
Cephalalgia. 2011 Oct;31(14):1439-51
pubmed: 21940490
Arch Neurol. 1961 May;4:475-85
pubmed: 13690161
Brain. 1996 Apr;119 ( Pt 2):355-61
pubmed: 8800932
Brain. 2016 Jul;139(Pt 7):1987-93
pubmed: 27190019
Headache. 2005 Nov-Dec;45(10):1388-93
pubmed: 16324171
Headache. 1994 May;34(5):282-5
pubmed: 8026947
Ann Neurol. 2017 Dec;82(6):925-939
pubmed: 29130510
Headache. 1973 Jan;12(4):135-42
pubmed: 4682551
Cephalalgia. 2004 Jul;24(7):564-75
pubmed: 15196299
Cephalalgia. 2012 Jan;32(1):3-5
pubmed: 22174361
J Headache Pain. 2015;16:92
pubmed: 26527348
Clin Neurophysiol. 2008 May;119(5):1190-200
pubmed: 18316245
Headache. 1975 Jan;14(4):193-8
pubmed: 1123302
Am J Otolaryngol. 2012 Jul-Aug;33(4):385-94
pubmed: 22133970
Ann Neurol. 2001 Nov;50(5):582-7
pubmed: 11706963
J Child Neurol. 1998 Jul;13(7):322-6
pubmed: 9701480
Headache. 1977 Mar;17(1):32-8
pubmed: 845025
Cephalalgia. 2011 Mar;31(4):444-55
pubmed: 21098109
Neurology. 1997 Jan;48(1):108-13
pubmed: 9008504
Eur J Neurosci. 2015 Jan;41(1):120-8
pubmed: 25327971
Exp Brain Res. 2015 May;233(5):1503-10
pubmed: 25700669
Clin Neurophysiol. 2004 Aug;115(8):1857-62
pubmed: 15261864
Cephalalgia. 2013 Nov;33(15):1264-8
pubmed: 23720503
Clin Neurol Neurosurg. 1988;90(3):275-8
pubmed: 3197358