African trypanosomes.
Sleeping sickness
Trypanosoma brucei
Trypanosome
Journal
Parasites & vectors
ISSN: 1756-3305
Titre abrégé: Parasit Vectors
Pays: England
ID NLM: 101462774
Informations de publication
Date de publication:
29 Apr 2019
29 Apr 2019
Historique:
received:
21
11
2018
accepted:
26
02
2019
entrez:
1
5
2019
pubmed:
1
5
2019
medline:
31
5
2019
Statut:
epublish
Résumé
African trypanosomes cause human African trypanosomiasis and animal African trypanosomiasis. They are transmitted by tsetse flies in sub-Saharan Africa. Although most famous for their mechanisms of immune evasion by antigenic variation, there have been recent important studies that illuminate important aspects of the biology of these parasites both in their mammalian host and during passage through their tsetse fly vector. This Primer overviews current research themes focused on these parasites and discusses how these biological insights and the development of new technologies to interrogate gene function are being used in the search for new approaches to control the parasite. The new insights into the biology of trypanosomes in their host and vector highlight that we are in a 'golden age' of discovery for these fascinating parasites.
Identifiants
pubmed: 31036044
doi: 10.1186/s13071-019-3355-5
pii: 10.1186/s13071-019-3355-5
pmc: PMC6489224
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
190Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 103740/Z14/Z
Pays : United Kingdom
Organisme : Wolfson Foundation
ID : WM140045
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