Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer.
Aged
Aged, 80 and over
Animals
DNA Methylation
Disease Models, Animal
Epigenesis, Genetic
Female
Gene Expression Regulation, Neoplastic
Hedgehog Proteins
/ genetics
Hedgehogs
/ genetics
Humans
Male
Mice
Middle Aged
Signal Transduction
/ genetics
Stromal Cells
/ metabolism
Survival Analysis
Urinary Bladder
/ pathology
Urinary Bladder Neoplasms
/ genetics
BMP signaling
bladder cancer
cancer biology
cancer subtype
epigenetics
hedgehog signaling
human
mouse
tumor stroma
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
30 04 2019
30 04 2019
Historique:
received:
21
10
2018
accepted:
19
04
2019
pubmed:
1
5
2019
medline:
5
3
2020
entrez:
1
5
2019
Statut:
epublish
Résumé
In bladder, loss of mammalian
Identifiants
pubmed: 31036156
doi: 10.7554/eLife.43024
pii: 43024
pmc: PMC6597241
doi:
pii:
Substances chimiques
Hedgehog Proteins
0
Banques de données
GEO
['GSE129441']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Foundation of Korea
ID : NRF-2017R1A2B4006043
Pays : International
Organisme : National Research Foundation of Korea
ID : NRF-2017M3C7A1047875
Pays : International
Organisme : National Research Foundation of Korea
ID : NRF-2017R1A5A1015366
Pays : International
Organisme : National Research Foundation of Korea
ID : Brain Korea 21 Program for Leading Universities & Students
Pays : International
Informations de copyright
© 2019, Kim et al.
Déclaration de conflit d'intérêts
SK, YK, JK, EK, JC, HY, HL, HK, KL, MK, JR, KM, SK, JK, KS No competing interests declared
Références
Cell. 2014 Oct 23;159(3):676-90
pubmed: 25417114
Nat Rev Cancer. 2004 Feb;4(2):143-53
pubmed: 14732866
Bioinformatics. 2004 Nov 22;20(17):3246-8
pubmed: 15180930
Nat Cell Biol. 2014 May;16(5):469-78
pubmed: 24747439
Cell. 2015 Nov 5;163(4):1011-25
pubmed: 26544944
Urol Oncol. 2017 Sep;35(9):576-577
pubmed: 28789929
Nature. 2005 Jun 30;435(7046):1262-6
pubmed: 15988529
Nat Rev Genet. 2002 Jun;3(6):415-28
pubmed: 12042769
Cancer Cell. 2014 Oct 13;26(4):521-33
pubmed: 25314078
Cell Host Microbe. 2009 May 8;5(5):463-75
pubmed: 19454350
N Engl J Med. 2012 Jun 7;366(23):2180-8
pubmed: 22670904
Cell. 2018 Apr 5;173(2):515-528.e17
pubmed: 29625057
Bioinformatics. 2004 Jun 12;20(9):1453-4
pubmed: 14871861
Science. 1997 Aug 22;277(5329):1109-13
pubmed: 9262482
Nature. 2005 Oct 6;437(7060):894-7
pubmed: 16208373
J Clin Oncol. 2016 Sep 10;34(26):3119-25
pubmed: 27269937
Bioinformatics. 2002 Nov;18(11):1427-31
pubmed: 12424112
J Clin Invest. 2013 Sep;123(9):3639-45
pubmed: 23999436
Cancer Cell. 2012 Mar 20;21(3):430-46
pubmed: 22439938
Nature. 2001 May 17;411(6835):349-54
pubmed: 11357142
Development. 2009 May;136(10):1665-74
pubmed: 19369396
Br J Cancer. 1970 Dec;24(4):746-54
pubmed: 5503601
Science. 2009 Jun 12;324(5933):1457-61
pubmed: 19460966
Oncogene. 2018 Apr;37(14):1911-1925
pubmed: 29367767
J Pathol. 2017 May;242(1):113-125
pubmed: 28195647
Cancer Cell. 2014 Jun 16;25(6):735-47
pubmed: 24856585
In Vivo. 2012 Jul-Aug;26(4):727-39
pubmed: 22773588
Nat Genet. 2009 Feb;41(2):178-186
pubmed: 19151715
Dis Model Mech. 2017 Jan 1;10(1):39-52
pubmed: 27935821
N Engl J Med. 2012 Jun 7;366(23):2171-9
pubmed: 22670903
Nat Protoc. 2012 Mar 01;7(3):562-78
pubmed: 22383036
Nature. 2012 Oct 4;490(7418):61-70
pubmed: 23000897
Nat Genet. 2015 Apr;47(4):320-9
pubmed: 25706628
Cancer Cell. 2014 Feb 10;25(2):152-65
pubmed: 24525232
Elife. 2019 Apr 30;8:
pubmed: 31036156
Genesis. 2002 Feb;32(2):69-72
pubmed: 11857780
Mol Cancer Ther. 2009 Jun;8(6):1409-20
pubmed: 19509247
Hum Mol Genet. 2003 Jul 15;12(14):1725-35
pubmed: 12837695
Science. 2015 Feb 13;347(6223):729-31
pubmed: 25678653
Br J Cancer. 1977 Feb;35(2):142-51
pubmed: 836756
Nature. 2014 Mar 20;507(7492):315-22
pubmed: 24476821
Cancer Discov. 2012 May;2(5):401-4
pubmed: 22588877
Bioinformatics. 2009 May 1;25(9):1105-11
pubmed: 19289445
N Engl J Med. 2003 Nov 20;349(21):2042-54
pubmed: 14627790
Br J Cancer. 1978 Jul;38(1):64-76
pubmed: 687519
Oncotarget. 2016 Aug 30;7(35):56147-56152
pubmed: 27528229
Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7545-E7553
pubmed: 27815529
Nature. 2008 Sep 18;455(7211):406-10
pubmed: 18754008
Cell. 2017 Oct 19;171(3):540-556.e25
pubmed: 28988769
J Clin Invest. 2013 Aug;123(8):3600-13
pubmed: 23867624
Drugs. 2013 May;73(7):613-23
pubmed: 23605693
Nat Genet. 2015 Apr;47(4):312-9
pubmed: 25706627
Biochim Biophys Acta. 2010 Apr;1805(2):181-208
pubmed: 20085802
Science. 2017 Mar 24;355(6331):1330-1334
pubmed: 28336671
J Clin Oncol. 2012 Feb 1;30(4):372-9
pubmed: 22203755
Nature. 2014 Nov 27;515(7528):558-62
pubmed: 25428503
Sci Signal. 2013 Apr 02;6(269):pl1
pubmed: 23550210
Nat Commun. 2016 Aug 05;7:12321
pubmed: 27492255
Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3110-5
pubmed: 24520177
Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3091-100
pubmed: 25024225
Cancer Metastasis Rev. 2013 Jun;32(1-2):303-15
pubmed: 23114846
Nature. 2011 Apr 7;472(7341):110-4
pubmed: 21389986
Int J Cancer. 1973 May;11(3):765-73
pubmed: 4133950
Anal Biochem. 2005 Jan 1;336(1):46-50
pubmed: 15582557