General Mechanisms Leading to Persister Formation and Awakening.

Anti-Bacterial Agents / pharmacology Bacteria / drug effects Bacterial Physiological Phenomena / drug effects DNA Replication Drug Resistance, Bacterial Energy Metabolism / drug effects Gene Expression Regulation, Bacterial / drug effects Transcription, Genetic
dormancy molecular mechanisms persistence

Journal

Trends in genetics : TIG
ISSN: 0168-9525
Titre abrégé: Trends Genet
Pays: England
ID NLM: 8507085

Informations de publication

Date de publication:
06 2019
Historique:
received: 01 02 2019
revised: 20 03 2019
accepted: 27 03 2019
pubmed: 1 5 2019
medline: 1 7 2020
entrez: 1 5 2019
Statut: ppublish

Résumé

All bacterial populations harbor a small fraction of transiently antibiotic-tolerant cells called persisters. These phenotypic variants compromise successful antibiotic treatment because they are held responsible for the relapse of many chronic infections. In addition, studies employing experimental evolution have demonstrated that persistence contributes to the development of antibiotic resistance. Persisters are typically described as dormant cells. However, recent findings indicate a role for active mechanisms in the formation and maintenance of the persister phenotype. This review summarizes novel insights into the molecular mechanisms of persister formation and awakening, focusing on changes in cell physiology mediated by persistence effectors.

Identifiants

DOI: 10.1016/j.tig.2019.03.007 PMID: 31036343
pubmed: 31036343
pii: S0168-9525(19)30053-8
doi: 10.1016/j.tig.2019.03.007
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

401-411

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Dorien Wilmaerts (D)

Center for Microbiology, Vlaams Instituut voor Biotechnologie (VIB), Leuven 3000, Belgium; Center of Microbial and Plant Genetics, Katholieke Universiteit (KU) Leuven, Leuven 3000, Belgium.

Etthel M Windels (EM)

Center for Microbiology, Vlaams Instituut voor Biotechnologie (VIB), Leuven 3000, Belgium; Center of Microbial and Plant Genetics, Katholieke Universiteit (KU) Leuven, Leuven 3000, Belgium.

Natalie Verstraeten (N)

Center for Microbiology, Vlaams Instituut voor Biotechnologie (VIB), Leuven 3000, Belgium; Center of Microbial and Plant Genetics, Katholieke Universiteit (KU) Leuven, Leuven 3000, Belgium.

Jan Michiels (J)

Center for Microbiology, Vlaams Instituut voor Biotechnologie (VIB), Leuven 3000, Belgium; Center of Microbial and Plant Genetics, Katholieke Universiteit (KU) Leuven, Leuven 3000, Belgium. Electronic address: jan.michiels@kuleuven.vib.be.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › General Mechanisms Leading to Persister...
questionsmedicales.fr › Bactéries › General Mechanisms Leading to Persister...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques bactériens › General Mechanisms Leading to Persister...
questionsmedicales.fr › Phénomènes génétiques › Réplication de l'ADN › General Mechanisms Leading to Persister...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance bactérienne aux médicaments › General Mechanisms Leading to Persister...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › General Mechanisms Leading to Persister...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes bactériens › General Mechanisms Leading to Persister...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › General Mechanisms Leading to Persister...