Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1.
Amino Acid Sequence
Cell Movement
Complement C5a
/ genetics
Endocytosis
HEK293 Cells
Humans
Interleukin-6
/ genetics
Macrophages
/ cytology
Mitogen-Activated Protein Kinase 1
/ genetics
Mitogen-Activated Protein Kinase 3
/ genetics
Neutrophils
/ metabolism
Phosphorylation
Protein Binding
Receptor, Anaphylatoxin C5a
/ genetics
Sequence Homology
Signal Transduction
beta-Arrestins
/ genetics
G-protein–coupled receptor (GPCR)
arrestin
cell signaling
complement
signal transduction
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
14 06 2019
14 06 2019
Historique:
received:
09
01
2019
revised:
17
04
2019
pubmed:
1
5
2019
medline:
26
2
2020
entrez:
1
5
2019
Statut:
ppublish
Résumé
The human complement component, C5a, binds two different seven-transmembrane receptors termed C5aR1 and C5aR2. C5aR1 is a prototypical G-protein-coupled receptor that couples to the Gα
Identifiants
pubmed: 31036565
pii: S0021-9258(20)36432-2
doi: 10.1074/jbc.RA119.007485
pmc: PMC6579481
doi:
Substances chimiques
C5AR1 protein, human
0
Interleukin-6
0
Receptor, Anaphylatoxin C5a
0
beta-Arrestins
0
Complement C5a
80295-54-1
MAPK1 protein, human
EC 2.7.11.24
MAPK3 protein, human
EC 2.7.11.24
Mitogen-Activated Protein Kinase 1
EC 2.7.11.24
Mitogen-Activated Protein Kinase 3
EC 2.7.11.24
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9416-9429Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : DBT-Wellcome Trust India Alliance
ID : IA/I/14/1/501285
Pays : India
Informations de copyright
© 2019 Pandey et al.
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