Correlation of Copper and Zinc in Spontaneous Abortion.

Copper Pregnancy Outcome Spontaneous Abortion Trace Elements Zinc

Journal

International journal of fertility & sterility
ISSN: 2008-076X
Titre abrégé: Int J Fertil Steril
Pays: Iran
ID NLM: 101487941

Informations de publication

Date de publication:
Jul 2019
Historique:
received: 24 05 2018
accepted: 24 11 2018
entrez: 1 5 2019
pubmed: 1 5 2019
medline: 1 5 2019
Statut: ppublish

Résumé

Humans require minute amounts of trace metals to maintain body's normal growth and physiological functions; such elements may also play a vital role in pregnancy and pregnancy outcome. The present study was conducted to assess the role of two trace metals, zinc (Zn) and copper (Cu) in women with history of spontaneous abortion (SAb cases) in comparison to women without such history (controls). In this retrospective study, a total of 277 subjects were enrolled from the Obstetrics and Gynecology Department, Civil Hospital, Ahmedabad, India. Personal demographic information, medical history, reproductive history especially details of number of SAb, duration of last SAb, number of children, etc. were recorded using predesigned and pre-tested proforma. Serum Zn and Cu levels were measured by an atomic absorption spectrophotometer. The data indicated that the serum level of Cu (P<0.01) and Zn was lower in SAb cases as compared to controls. Correlation between the number of SAbs and trace metals levels showed a significant negative correlation between Cu and Cu/Zn and the number of SAbs. Cu/Zn was higher in controls and women having at least one child as compared cases and women without child, respectively. Pregnant women had higher levels of trace elements as compared to non-pregnant women at the time of enrollment. The data revealed that trace metals such as Zn and Cu have a positive role in pregnancy outcome and optimum levels of Zn and Cu might be able to decline the chances of SAb occurrence in addition to other factors. The ratio of Cu/Zn has a positive role in reproductive outcomes.

Sections du résumé

BACKGROUND BACKGROUND
Humans require minute amounts of trace metals to maintain body's normal growth and physiological functions; such elements may also play a vital role in pregnancy and pregnancy outcome. The present study was conducted to assess the role of two trace metals, zinc (Zn) and copper (Cu) in women with history of spontaneous abortion (SAb cases) in comparison to women without such history (controls).
MATERIALS AND METHODS METHODS
In this retrospective study, a total of 277 subjects were enrolled from the Obstetrics and Gynecology Department, Civil Hospital, Ahmedabad, India. Personal demographic information, medical history, reproductive history especially details of number of SAb, duration of last SAb, number of children, etc. were recorded using predesigned and pre-tested proforma. Serum Zn and Cu levels were measured by an atomic absorption spectrophotometer.
RESULTS RESULTS
The data indicated that the serum level of Cu (P<0.01) and Zn was lower in SAb cases as compared to controls. Correlation between the number of SAbs and trace metals levels showed a significant negative correlation between Cu and Cu/Zn and the number of SAbs. Cu/Zn was higher in controls and women having at least one child as compared cases and women without child, respectively. Pregnant women had higher levels of trace elements as compared to non-pregnant women at the time of enrollment.
CONCLUSION CONCLUSIONS
The data revealed that trace metals such as Zn and Cu have a positive role in pregnancy outcome and optimum levels of Zn and Cu might be able to decline the chances of SAb occurrence in addition to other factors. The ratio of Cu/Zn has a positive role in reproductive outcomes.

Identifiants

DOI: 10.22074/ijfs.2019.5586 PMID: 31037918 PMC: PMC6500075
pubmed: 31037918
doi: 10.22074/ijfs.2019.5586
pmc: PMC6500075
doi:

Types de publication

Journal Article

Langues

eng

Pagination

97-101

Informations de copyright

Copyright© by Royan Institute. All rights reserved.

Déclaration de conflit d'intérêts

The authors declare no conflicts of interest.

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Auteurs

Riddhi Thaker (R)

Division of Reproductive and Cytotoxicology, ICMR-National Institute of Occupational Health, Ahmedabad, India.

Hina Oza (H)

Department of Obstetrics and Gynecology, Civil Hospital, Ahmedabad, India.

Idrish Shaikh (I)

Division of Reproductive and Cytotoxicology, ICMR-National Institute of Occupational Health, Ahmedabad, India.

Sunil Kumar (S)

Division of Reproductive and Cytotoxicology, ICMR-National Institute of Occupational Health, Ahmedabad, India. Electronic Address: sunilnioh@gmail.com.

Classifications MeSH