Enhanced bone formation onto the bone surface using a hydroxyapatite/collagen bone-like nanocomposite.
Animals
Biomedical Enhancement
Bone Regeneration
Bone Substitutes
/ chemistry
Collagen
/ chemistry
Durapatite
/ chemistry
Humans
Hydrogen-Ion Concentration
Nanocomposites
/ chemistry
Osteogenesis
Periosteum
/ chemistry
Porosity
Rats
Tissue Engineering
Tissue Scaffolds
/ chemistry
X-Ray Microtomography
TRAP-positive multinucleated cells
bone substitutes
bulk erosion
hydroxyapatite/collagen bone-like nanocomposite
subperiosteal bone formation
Journal
Journal of biomedical materials research. Part B, Applied biomaterials
ISSN: 1552-4981
Titre abrégé: J Biomed Mater Res B Appl Biomater
Pays: United States
ID NLM: 101234238
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
28
11
2018
revised:
24
03
2019
accepted:
17
04
2019
pubmed:
1
5
2019
medline:
10
8
2021
entrez:
1
5
2019
Statut:
ppublish
Résumé
The process of bone formation onto the bone surface using a hydroxyapatite/collagen bone-like nanocomposite (HAp/Col) was investigated. Immersion tests were performed to evaluate the impact of pH on the degradation of the specimens in an aqueous environment. The specimens were soaked in aqueous solutions of pH 4.0, 5.0, and 7.0. Using standardized images, the top-view areas of the specimens were measured. Animal experiments were performed to investigate the bone formation process onto the bone surface. The specimens were placed under the rat calvarial periosteum, and μCT image analysis and histological observation were performed on samples harvested on postoperative Days 3, 5, and 7. In all experiments, β-tricalciumphosphate (β-TCP) was adopted as the control. HAp/Col turned to gel in acidic environments below pH 5.0. In contrast to the β-TCP, the HAp/Col specimens placed under the periosteum expanded and attained a hollow structure with a gel-filled center, accompanied by larger volume of new bone and appearance of TRAP-positive multinucleated cells on postoperative Day 5. Therefore, HAp/Col can enhance bone formation onto the bone surface via induction of TRAP-positive multinucleated cells, and may have clinical applications.
Substances chimiques
Bone Substitutes
0
Collagen
9007-34-5
Durapatite
91D9GV0Z28
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
391-398Informations de copyright
© 2019 Wiley Periodicals, Inc.
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