Oscillatory hyperactivity and hyperconnectivity in young
Adult
Aged
Aged, 80 and over
Alzheimer Disease
/ diagnostic imaging
Apolipoprotein E4
/ genetics
Brain
/ diagnostic imaging
Brain Mapping
/ methods
Female
Genetic Predisposition to Disease
Genotype
Heterozygote
Humans
Image Processing, Computer-Assisted
Machine Learning
Magnetic Resonance Imaging
Magnetoencephalography
/ methods
Male
Parietal Lobe
Sensitivity and Specificity
Young Adult
APOE-ɛ4
Alzheimer's disease
functional connectivity
human
neural oscillations
neuroscience
parietal cortex
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
30 04 2019
30 04 2019
Historique:
received:
26
02
2018
accepted:
17
04
2019
entrez:
1
5
2019
pubmed:
1
5
2019
medline:
5
3
2020
Statut:
epublish
Résumé
We studied resting-state oscillatory connectivity using magnetoencephalography in healthy young humans (N = 183) genotyped for APOE-ɛ4, the greatest genetic risk for Alzheimer's disease (AD). Connectivity across frequencies, but most prevalent in alpha/beta, was increased in APOE-ɛ4 in a set of mostly right-hemisphere connections, including lateral parietal and precuneus regions of the Default Mode Network. Similar regions also demonstrated hyperactivity, but only in gamma (40-160 Hz). In a separate study of AD patients, hypoconnectivity was seen in an extended bilateral network that partially overlapped with the hyperconnected regions seen in young APOE-ɛ4 carriers. Using machine-learning, AD patients could be distinguished from elderly controls with reasonable sensitivity and specificity, while young APOE-e4 carriers could also be distinguished from their controls with above chance performance. These results support theories of initial hyperconnectivity driving eventual profound disconnection in AD and suggest that this is present decades before the onset of AD symptomology.
Identifiants
pubmed: 31038453
doi: 10.7554/eLife.36011
pii: 36011
pmc: PMC6491037
doi:
pii:
Substances chimiques
Apolipoprotein E4
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MR/K004360/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K005464/1
Pays : United Kingdom
Organisme : Wellcome
ID : WT105613/Z/14/Z
Pays : International
Organisme : Medical Research Council
ID : MR/K501086/1
Pays : United Kingdom
Informations de copyright
© 2019, Koelewijn et al.
Déclaration de conflit d'intérêts
LK, TL, DL, DD, BR, LM, KB, LB, RA, KT, AB, AT, AB, KS No competing interests declared
Références
Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18700-5
pubmed: 16344478
JAMA. 1995 Apr 26;273(16):1274-8
pubmed: 7646655
Nat Genet. 2012 Apr 15;44(5):552-61
pubmed: 22504417
J Alzheimers Dis. 2015;44(2):493-505
pubmed: 25281603
Phys Med Biol. 2003 Nov 21;48(22):3637-52
pubmed: 14680264
Neurology. 2009 Apr 28;72(17):1487-94
pubmed: 19339712
J Neurosci. 2011 May 25;31(21):7775-83
pubmed: 21613490
PLoS One. 2012;7(9):e46289
pubmed: 23050006
Sci Rep. 2015 Nov 10;5:16322
pubmed: 26552581
Am J Psychiatry. 2008 Feb;165(2):214-20
pubmed: 18172018
PLoS One. 2012;7(11):e48895
pubmed: 23152815
Neuroimage. 2012 Feb 15;59(4):3909-21
pubmed: 22122866
Ann Neurol. 2009 Jun;65(6):650-7
pubmed: 19557866
Neurobiol Aging. 2008 Jun;29(6):819-27
pubmed: 17293007
Neuroimage. 2014 Apr 15;90:423-35
pubmed: 24321555
Nat Genet. 2016 Oct;48(10):1279-83
pubmed: 27548312
Neuroimage Clin. 2015 Aug 01;9:103-9
pubmed: 26448910
PLoS Comput Biol. 2012;8(8):e1002582
pubmed: 22915996
Cereb Cortex. 2008 Aug;18(8):1856-64
pubmed: 18063564
Neuroimage. 2003 Aug;19(4):1589-601
pubmed: 12948714
Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6820-5
pubmed: 19346482
Ann Neurol. 2010 Jan;67(1):122-31
pubmed: 20186853
Hum Brain Mapp. 2009 Jul;30(7):2098-119
pubmed: 18781594
Nat Genet. 2016 Oct;48(10):1284-1287
pubmed: 27571263
Neuroimage. 2014 May 15;92:381-97
pubmed: 24530839
Nat Neurosci. 2015 Jun;18(6):794-9
pubmed: 26007212
Neurobiol Aging. 2013 Sep;34(9):2158-63
pubmed: 23587637
Biol Psychiatry. 2018 Feb 15;83(4):347-357
pubmed: 28434655
Science. 2008 Sep 19;321(5896):1686-9
pubmed: 18802001
Gigascience. 2015 Feb 25;4:7
pubmed: 25722852
Comput Intell Neurosci. 2011;2011:156869
pubmed: 21253357
Neuroimage. 2015 Aug 15;117:439-48
pubmed: 25862259
Neuroimage. 2002 Jan;15(1):273-89
pubmed: 11771995
Neurosci Lett. 2009 Oct 23;464(2):140-5
pubmed: 19616072
Neuroimage. 2010 Dec;53(4):1197-207
pubmed: 20600983
Brain. 2014 Jul;137(Pt 7):2052-64
pubmed: 24771519
Prog Neurobiol. 2011 Dec;95(4):579-93
pubmed: 21130138
Neuron. 2014 Feb 19;81(4):740-54
pubmed: 24559670
J Psychopharmacol. 2017 Dec;31(12):1527-1536
pubmed: 29084475
Neuroimage. 2016 Feb 1;126:81-95
pubmed: 26631815
Clin Neurophysiol. 2017 Nov;128(11):2347-2357
pubmed: 28571910
Neurology. 2006 Oct 10;67(7):1221-4
pubmed: 17030756
Neurosci Biobehav Rev. 2013 Sep;37(8):1322-35
pubmed: 23701948
Science. 1993 Aug 13;261(5123):921-3
pubmed: 8346443
Neurobiol Aging. 2013 Aug;34(8):2023-36
pubmed: 23541878
Am J Psychiatry. 2008 Feb;165(2):203-13
pubmed: 18172019
Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3867-72
pubmed: 27001844
Neurology. 2010 Jun 15;74(24):1969-76
pubmed: 20463288
Nat Rev Neurosci. 2005 Apr;6(4):285-96
pubmed: 15803160
Elife. 2017 Feb 08;6:
pubmed: 28177283
Neuroimage. 2012 Feb 15;59(4):3085-93
pubmed: 22154957
Ann Neurol. 2006 Feb;59(2):323-34
pubmed: 16358334
Psychol Methods. 2008 Mar;13(1):19-30
pubmed: 18331151
Nat Commun. 2017 Nov 13;8(1):1464
pubmed: 29133888
J Neurosci. 2010 Dec 15;30(50):17035-40
pubmed: 21159973
Neurobiol Aging. 2019 Jan;73:82-91
pubmed: 30339963
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Neuroimage. 2018 Apr 1;169:23-45
pubmed: 28893608
Lancet Neurol. 2011 Mar;10(3):280-8
pubmed: 21185234
Trends Cogn Sci. 2011 May;15(5):191-9
pubmed: 21481630
Neurobiol Aging. 2015 Jan;36(1):1-11
pubmed: 25444609
J Neurol Neurosurg Psychiatry. 1998 Sep;65(3):322-7
pubmed: 9728943
Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13510-13515
pubmed: 27830650
Methods. 2001 Oct;25(2):249-71
pubmed: 11812209
Neurology. 1984 Jul;34(7):939-44
pubmed: 6610841
Brain. 2016 May;139(Pt 5):1551-67
pubmed: 26962052
Ageing Res Rev. 2016 Sep;30:73-84
pubmed: 26876244
Nat Genet. 2016 Nov;48(11):1443-1448
pubmed: 27694958
PLoS Biol. 2011 Apr;9(4):e1000610
pubmed: 21532743
Hum Brain Mapp. 2002 Jan;15(1):1-25
pubmed: 11747097
Neuroimage. 2009 Feb 1;44(3):724-8
pubmed: 19013250
Clin Neurophysiol. 2008 Dec;119(12):2727-32
pubmed: 18848805
Neuroimage. 2016 Sep;138:284-293
pubmed: 27262239
Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7209-14
pubmed: 19357304
Hum Mol Genet. 2010 Aug 15;19(16):3295-301
pubmed: 20534741
Brain. 2015 Dec;138(Pt 12):3673-84
pubmed: 26490334
J Neurol Neurosurg Psychiatry. 1997 Jul;63(1):59-65
pubmed: 9221969
Ann N Y Acad Sci. 2008 Mar;1124:1-38
pubmed: 18400922
Mol Psychiatry. 2011 Sep;16(9):908-16
pubmed: 20820167
Nat Neurosci. 2017 Feb 23;20(3):327-339
pubmed: 28230841
Neuroreport. 2006 Oct 23;17(15):1585-90
pubmed: 17001273
Neuroimage. 2016 Apr 1;129:345-355
pubmed: 26827813
Ann Clin Transl Neurol. 2015 Dec 21;3(2):124-31
pubmed: 26900581