Phagocytosis in the Brain: Homeostasis and Disease.
macrophage
microglia
neurodegeneration
neuroinflammation
phagocytosis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
15
01
2019
accepted:
26
03
2019
entrez:
2
5
2019
pubmed:
2
5
2019
medline:
10
9
2020
Statut:
epublish
Résumé
Microglia are resident macrophages of the central nervous system and significantly contribute to overall brain function by participating in phagocytosis during development, homeostasis, and diseased states. Phagocytosis is a highly complex process that is specialized for the uptake and removal of opsonized and non-opsonized targets, such as pathogens, apoptotic cells, and cellular debris. While the role of phagocytosis in mediating classical innate and adaptive immune responses has been known for decades, it is now appreciated that phagocytosis is also critical throughout early neural development, homeostasis, and initiating repair mechanisms. As such, modulating phagocytic processes has provided unexplored avenues with the intent of developing novel therapeutics that promote repair and regeneration in the CNS. Here, we review the functional consequences that phagocytosis plays in both the healthy and diseased CNS, and summarize how phagocytosis contributes to overall pathophysiological mechanisms involved in brain injury and repair.
Identifiants
pubmed: 31040847
doi: 10.3389/fimmu.2019.00790
pmc: PMC6477030
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
790Subventions
Organisme : Medical Research Council
ID : MR/N008219/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N026934/1
Pays : United Kingdom
Commentaires et corrections
Type : ErratumIn
Références
Am J Pathol. 1999 Mar;154(3):927-36
pubmed: 10079271
Prog Neurobiol. 1999 Apr;57(6):563-81
pubmed: 10221782
Exp Neurol. 1999 Aug;158(2):351-65
pubmed: 10415142
J Biol Chem. 1999 Nov 5;274(45):32301-8
pubmed: 10542270
Dev Biol. 1999 Dec 1;216(1):359-68
pubmed: 10588885
J Neuroimmunol. 2000 Jan 24;102(2):154-62
pubmed: 10636484
Exp Neurol. 2000 Jan;161(1):127-38
pubmed: 10683279
Neuron. 2000 Feb;25(2):269-78
pubmed: 10719884
J Comp Neurol. 2000 Apr 10;419(3):364-76
pubmed: 10723011
Mol Cell Biol. 2000 Jun;20(11):4106-14
pubmed: 10805752
Am J Hum Genet. 2002 Sep;71(3):656-62
pubmed: 12080485
J Clin Invest. 2003 Feb;111(3):323-32
pubmed: 12569157
Acta Neuropathol. 1992;84(3):225-33
pubmed: 1414275
J Neurocytol. 2002 Sep-Nov;31(8-9):581-93
pubmed: 14501200
Science. 2003 Oct 31;302(5646):841
pubmed: 14593171
Neuron. 2004 Feb 19;41(4):535-47
pubmed: 14980203
Glia. 2004 Apr 15;46(2):101-15
pubmed: 15042579
Glia. 2004 Apr 15;46(2):195-206
pubmed: 15042586
J Neurosci. 2004 Jul 21;24(29):6457-65
pubmed: 15269255
Neuron. 2004 Nov 18;44(4):601-7
pubmed: 15541309
J Neurosci. 2004 Dec 15;24(50):11421-8
pubmed: 15601948
Neurobiol Dis. 2005 Feb;18(1):166-75
pubmed: 15649707
Science. 1992 Apr 10;256(5054):184-5
pubmed: 1566067
Lancet. 2005 Jan 29-Feb 4;365(9457):415-6
pubmed: 15680457
J Exp Med. 2005 Feb 21;201(4):647-57
pubmed: 15728241
Science. 2005 May 27;308(5726):1314-8
pubmed: 15831717
Nat Neurosci. 2005 Jun;8(6):752-8
pubmed: 15895084
J Neurosci Res. 2005 Aug 1;81(3):357-62
pubmed: 15948177
J Neurosci. 2006 Jan 4;26(1):328-32
pubmed: 16399703
Nature. 2006 Aug 24;442(7105):920-4
pubmed: 16862115
Nature. 2006 Aug 24;442(7105):916-9
pubmed: 16862116
Glia. 2007 Mar;55(4):412-24
pubmed: 17203473
Neurobiol Aging. 2008 May;29(5):707-15
pubmed: 17222479
Mol Biol Cell. 2007 Apr;18(4):1490-6
pubmed: 17314396
Eur J Immunol. 2007 May;37(5):1290-301
pubmed: 17407101
PLoS Med. 2007 Apr;4(4):e124
pubmed: 17425404
Exp Neurol. 2008 Feb;209(2):378-88
pubmed: 17662717
Ann Neurol. 1991 Oct;30(4):572-80
pubmed: 1789684
Cell. 2007 Dec 14;131(6):1164-78
pubmed: 18083105
J Neurosci. 2008 Jan 2;28(1):264-78
pubmed: 18171944
J Neurosci. 2008 Apr 16;28(16):4283-92
pubmed: 18417708
Cell. 2008 May 30;133(5):916-27
pubmed: 18510934
Neurology. 2008 Aug 26;71(9):656-64
pubmed: 18565828
Brain. 2009 Feb;132(Pt 2):288-95
pubmed: 18567623
J Neurosci. 2008 Aug 6;28(32):8138-43
pubmed: 18685038
Eur J Neurol. 2008 Oct;15(10):1111-7
pubmed: 18752597
Acta Neuropathol. 2009 Mar;117(3):321-8
pubmed: 19125256
J Cell Biol. 2009 Jan 26;184(2):215-23
pubmed: 19171755
Stroke. 2009 May;40(5):1849-57
pubmed: 19265055
J Neurochem. 2009 May;109(4):1144-56
pubmed: 19302484
Glia. 2009 Nov 15;57(15):1610-8
pubmed: 19382211
PLoS Med. 2009 Jul;6(7):e1000113
pubmed: 19636355
Immunity. 2009 Aug 21;31(2):245-58
pubmed: 19646905
Neuron. 2009 Aug 13;63(3):287-303
pubmed: 19679070
Nat Genet. 2009 Oct;41(10):1088-93
pubmed: 19734902
Nat Genet. 2009 Oct;41(10):1094-9
pubmed: 19734903
J Neurosci. 2009 Oct 28;29(43):13435-44
pubmed: 19864556
Lancet Neurol. 2010 Jan;9(1):119-28
pubmed: 20083042
Cell. 2010 Mar 5;140(5):619-30
pubmed: 20211132
Anat Rec. 1991 Mar;229(3):384-98
pubmed: 2024779
Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7975-80
pubmed: 20375278
J Neural Transm (Vienna). 2010 Aug;117(8):949-60
pubmed: 20552234
Neurobiol Aging. 2012 Jan;33(1):195.e1-12
pubmed: 20580465
J Cell Biol. 2010 Jun 28;189(7):1059-70
pubmed: 20584912
Glia. 2010 Dec;58(16):2017-30
pubmed: 20878768
Cell Stem Cell. 2010 Oct 8;7(4):483-95
pubmed: 20887954
PLoS Biol. 2010 Nov 02;8(11):e1000527
pubmed: 21072242
Neuropathology. 2011 Aug;31(4):363-75
pubmed: 21118401
Science. 2010 Dec 24;330(6012):1774
pubmed: 21148344
PLoS One. 2011 Feb 08;6(2):e16964
pubmed: 21347448
J Alzheimers Dis. 2011;25(2):279-93
pubmed: 21403390
Mol Biol Cell. 2011 May 15;22(10):1664-76
pubmed: 21441306
Nat Genet. 2011 May;43(5):429-35
pubmed: 21460840
Nat Genet. 2011 May;43(5):436-41
pubmed: 21460841
Brain. 2011 Jul;134(Pt 7):1882-900
pubmed: 21507994
J Neuroinflammation. 2011 May 15;8:49
pubmed: 21569627
Nat Rev Neurosci. 2011 Jun 15;12(7):388-99
pubmed: 21673720
Mol Neurodegener. 2011 Jun 30;6:45
pubmed: 21718498
J Neurosci. 2011 Jul 6;31(27):9910-22
pubmed: 21734283
Science. 2011 Sep 9;333(6048):1456-8
pubmed: 21778362
Nat Cell Biol. 2011 Jul 31;13(9):1076-83
pubmed: 21804544
Nature. 2011 Aug 10;476(7359):214-9
pubmed: 21833088
Annu Rev Pathol. 2012;7:61-98
pubmed: 21910624
Glia. 2012 Apr;60(4):541-58
pubmed: 22223464
Methods Mol Biol. 2012;844:157-76
pubmed: 22262441
Glia. 2012 May;60(5):717-27
pubmed: 22290798
J Neuropathol Exp Neurol. 2012 Mar;71(3):180-97
pubmed: 22318123
J Neurosci. 2012 Feb 22;32(8):2657-66
pubmed: 22357850
Acta Neuropathol. 1990;80(4):415-8
pubmed: 2239153
Nat Rev Neurosci. 2012 Mar 07;13(4):240-50
pubmed: 22395804
Glia. 2012 May;60(6):993-1003
pubmed: 22438044
Cold Spring Harb Protoc. 2012 May 01;2012(5):null
pubmed: 22550299
Neuron. 2012 May 24;74(4):691-705
pubmed: 22632727
Annu Rev Neurosci. 2012;35:369-89
pubmed: 22715882
N Engl J Med. 2013 Jan 10;368(2):107-16
pubmed: 23150908
N Engl J Med. 2013 Jan 10;368(2):117-27
pubmed: 23150934
Dev Cell. 2012 Dec 11;23(6):1189-202
pubmed: 23201120
Brain. 2013 Jan;136(Pt 1):147-67
pubmed: 23266461
Immunity. 2013 Mar 21;38(3):555-69
pubmed: 23477737
Glia. 2013 Jun;61(6):929-42
pubmed: 23483680
Neuron. 2013 May 22;78(4):631-43
pubmed: 23623698
Mol Neurodegener. 2013 Jun 21;8:19
pubmed: 23800361
J Neurosci. 2013 Aug 14;33(33):13460-74
pubmed: 23946404
Aging Cell. 2014 Feb;13(1):60-9
pubmed: 23953759
Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):E4098-107
pubmed: 24101459
Curr Opin Neurobiol. 2013 Dec;23(6):1034-40
pubmed: 24157239
Nat Genet. 2013 Dec;45(12):1452-8
pubmed: 24162737
Nature. 2013 Dec 19;504(7480):394-400
pubmed: 24270812
Cold Spring Harb Protoc. 2013 Dec 01;2013(12):1142-8
pubmed: 24298036
Trends Neurosci. 2014 Mar;37(3):125-35
pubmed: 24388427
Exp Neurol. 2014 Apr;254:109-20
pubmed: 24468477
Curr Opin Neurobiol. 2014 Aug;27:53-60
pubmed: 24632308
Nat Rev Neurosci. 2014 Apr;15(4):209-16
pubmed: 24646669
J Neurosci. 2014 Apr 30;34(18):6316-22
pubmed: 24790202
Mol Neurodegener. 2014 Jun 03;9:20
pubmed: 24893973
Nat Commun. 2014 Jun 05;5:4046
pubmed: 24898390
Sci Transl Med. 2014 Jul 2;6(243):243ra86
pubmed: 24990881
J Exp Med. 2014 Jul 28;211(8):1533-49
pubmed: 25002752
J Neurosci. 2014 Aug 6;34(32):10511-27
pubmed: 25100586
Nat Med. 2014 Oct;20(10):1157-64
pubmed: 25261995
J Neurosci. 2015 Jan 14;35(2):748-60
pubmed: 25589768
Nat Commun. 2015 Jan 29;6:6176
pubmed: 25630253
Acta Neuropathol. 2015 Mar;129(3):429-47
pubmed: 25631124
Cold Spring Harb Perspect Biol. 2015 Feb 06;7(9):a020370
pubmed: 25663667
J Neurosci. 2015 Feb 25;35(8):3384-96
pubmed: 25716838
Cell. 2015 Mar 12;160(6):1061-71
pubmed: 25728668
J Exp Med. 2015 Mar 9;212(3):287-95
pubmed: 25732305
Lancet Neurol. 2015 Apr;14(4):388-405
pubmed: 25792098
Brain. 2015 May;138(Pt 5):1138-59
pubmed: 25823474
J Clin Invest. 2015 May;125(5):2161-70
pubmed: 25893602
J Neuroinflammation. 2015 May 29;12:106
pubmed: 26022493
Glia. 2015 Dec;63(12):2220-30
pubmed: 26179283
Nat Immunol. 2015 Sep;16(9):907-17
pubmed: 26287597
Neuroscience. 2015 Oct 29;307:311-8
pubmed: 26342747
J Biol Chem. 2015 Oct 23;290(43):26043-50
pubmed: 26374899
J Neurosci. 2015 Sep 23;35(38):13029-42
pubmed: 26400934
Sci Rep. 2015 Sep 29;5:14624
pubmed: 26416689
Acta Neuropathol. 2016 Mar;131(3):379-91
pubmed: 26576561
Nat Rev Drug Discov. 2016 Feb;15(2):110-24
pubmed: 26634996
Neuron. 2016 Jan 6;89(1):37-53
pubmed: 26687838
J Neuropathol Exp Neurol. 1989 Sep;48(5):499-506
pubmed: 2671269
Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):E1738-46
pubmed: 26884166
Nat Commun. 2016 Mar 07;7:10905
pubmed: 26948129
J Immunol. 2016 Apr 15;196(8):3375-84
pubmed: 26962228
Cell Death Differ. 2016 Jun;23(6):915-26
pubmed: 26990661
Science. 2016 May 6;352(6286):712-716
pubmed: 27033548
Nature. 2016 Apr 14;532(7598):240-244
pubmed: 27049947
J Exp Med. 2016 May 2;213(5):667-75
pubmed: 27091843
Cell. 2016 May 5;165(4):921-35
pubmed: 27114033
Nat Commun. 2016 May 03;7:11499
pubmed: 27139776
Neuron. 2016 May 18;90(4):724-39
pubmed: 27196974
Mult Scler. 2016 Aug;22(9):1114-24
pubmed: 27207458
Nat Neurosci. 2016 Aug;19(8):995-8
pubmed: 27294511
Front Aging Neurosci. 2016 Jul 05;8:160
pubmed: 27458370
Glia. 2016 Dec;64(12):2079-2092
pubmed: 27470986
Neuron. 2016 Jul 20;91(2):328-40
pubmed: 27477018
Science. 2016 Aug 19;353(6301):783-5
pubmed: 27540166
Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10186-91
pubmed: 27559087
PLoS Genet. 2016 Oct 20;12(10):e1006327
pubmed: 27764101
J Neuroinflammation. 2016 Nov 4;13(1):285
pubmed: 27814740
Brain. 2017 Feb;140(2):399-413
pubmed: 28007993
Nature. 2017 Jan 26;541(7638):481-487
pubmed: 28099414
J Neurosci. 2017 Jan 18;37(3):637-647
pubmed: 28100745
Cell Mol Life Sci. 2017 Jun;74(12):2167-2201
pubmed: 28197669
Geroscience. 2017 Apr;39(2):199-220
pubmed: 28238188
Nat Neurosci. 2017 May;20(5):753-759
pubmed: 28253233
Neuron. 2017 Apr 19;94(2):278-293.e9
pubmed: 28426964
Stem Cell Reports. 2017 Jun 6;8(6):1516-1524
pubmed: 28528700
J Neurosci. 2017 May 24;37(21):5263-5273
pubmed: 28539349
Science. 2017 Jun 23;356(6344):
pubmed: 28546318
Sci Transl Med. 2017 May 31;9(392):
pubmed: 28566429
Stem Cell Reports. 2017 Jun 6;8(6):1727-1742
pubmed: 28591653
Cell. 2017 Jun 15;169(7):1276-1290.e17
pubmed: 28602351
Nat Neurosci. 2017 Aug;20(8):1052-1061
pubmed: 28628103
Stem Cell Reports. 2017 Aug 8;9(2):600-614
pubmed: 28757165
Neuron. 2017 Aug 16;95(4):779-790.e6
pubmed: 28817799
Glia. 2017 Nov;65(11):1744-1761
pubmed: 28836393
Exp Neurol. 2018 Mar;301(Pt B):120-132
pubmed: 28843543
Nat Med. 2017 Sep 8;23(9):1018-1027
pubmed: 28886007
Sci Rep. 2017 Sep 11;7(1):11118
pubmed: 28894284
Glia. 2017 Dec;65(12):2051-2069
pubmed: 28925029
Immunity. 2017 Sep 19;47(3):566-581.e9
pubmed: 28930663
J Immunol. 2017 Nov 15;199(10):3583-3591
pubmed: 28993515
Neuron. 2017 Nov 1;96(3):697-708
pubmed: 29096081
Bio Protoc. 2016 Nov 5;6(21):null
pubmed: 29104891
Semin Immunopathol. 2018 Jan;40(1):113-124
pubmed: 29134267
Immunity. 2017 Nov 21;47(5):913-927.e6
pubmed: 29150239
Biol Psychiatry. 2018 Feb 15;83(4):377-387
pubmed: 29169609
J Cell Biol. 2018 Feb 5;217(2):459-472
pubmed: 29196460
Front Neurosci. 2017 Dec 12;11:680
pubmed: 29311768
Neurol Neuroimmunol Neuroinflamm. 2017 Oct 16;4(6):e402
pubmed: 29379818
Nat Commun. 2018 Feb 7;9(1):539
pubmed: 29416036
Intractable Rare Dis Res. 2018 Feb;7(1):32-36
pubmed: 29552443
Nat Neurosci. 2018 May;21(5):683-695
pubmed: 29556031
Nat Commun. 2018 Mar 26;9(1):1228
pubmed: 29581545
Immunity. 2018 May 15;48(5):979-991.e8
pubmed: 29752066
Front Mol Neurosci. 2018 Apr 27;11:144
pubmed: 29755317
Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5164-E5173
pubmed: 29760073
Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):6303-6308
pubmed: 29844190
Curr Protoc Immunol. 2018 May 24;:e49
pubmed: 29927067
Cell Rep. 2018 Aug 28;24(9):2300-2311
pubmed: 30157425
Neuron. 2018 Oct 10;100(1):120-134.e6
pubmed: 30308165
PLoS Biol. 2018 Oct 17;16(10):e2005264
pubmed: 30332405
Nat Genet. 2018 Dec;50(12):1716-1727
pubmed: 30397336
Neuron. 2019 Jan 16;101(2):207-223.e10
pubmed: 30606613
Proc Natl Acad Sci U S A. 1982 May;79(10):3290-4
pubmed: 6954480
Ann Neurol. 1981 Aug;10(2):149-58
pubmed: 7025748
J Neurosci Res. 1993 Aug 1;35(5):480-7
pubmed: 7690856
J Neurosci Res. 1994 Jul 1;38(4):433-43
pubmed: 7932874
Neurology. 1993 Aug;43(8):1467-72
pubmed: 8350998
J Comp Neurol. 1993 Jan 1;327(1):123-32
pubmed: 8432904
J Neuroimmunol. 1993 Mar;43(1-2):169-76
pubmed: 8458985
Exp Neurol. 1996 Mar;138(1):22-32
pubmed: 8593893
Neurochem Res. 1996 Apr;21(4):481-7
pubmed: 8734442
J Cell Biol. 1997 Apr 21;137(2):459-68
pubmed: 9128255
Neurochem Res. 1997 Apr;22(4):491-8
pubmed: 9130261
J Biol Chem. 1997 Nov 14;272(46):29390-7
pubmed: 9361021
Eur J Neurosci. 1997 Dec;9(12):2650-7
pubmed: 9517470