Beneficial effects of gluten free diet on IgA tissue transglutaminase levels and various growth parameters in celiac disease patients.
Anemia
celiac disease
child
diet
gluten-free
growth
immunoglobin A
Journal
Journal of family medicine and primary care
ISSN: 2249-4863
Titre abrégé: J Family Med Prim Care
Pays: India
ID NLM: 101610082
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
entrez:
2
5
2019
pubmed:
2
5
2019
medline:
2
5
2019
Statut:
ppublish
Résumé
In the resource poor country like India it is difficult to get HLA screening and EMA testing in patients with celiac disease in small centres. To study the effect of gluten free diet on IgA tissue transglutaminase levels and various growth parameters in patients with celiac disease. This was a prospective study conducted in the department of paediatrics of a tertiary referral hospital in north India in 3 stages viz. on presentation, after 3 months and 6 months of initial presentation. 392 patients with symptoms suggestive of celiac disease were screened for IgA tTG levels more than 10 folds of upper limit of normal. 50 cases (who followed up for 6 months regularly) were enrolled in the study. Spectrum of various growth and clinical parameters were also studied. Statistical analysis used: Statistical analysis was performed by the SPSS version 20.0. Data were checked for normality before statistical analysis. p value less than 0.05 was considered statistically significant. 50 cases were enrolled in study. After initiation of gluten free diet, improvements were seen in various growth factors like height (12.71%) and weight (3.47 cm) after 6 months. Serum tTG(IgA) levels decreased to 94.88±55.35 U/mL from baseline level of 202±83.96 U/mL after 6 months. Gluten free diet has major role in improvement in growth parameters as well as anemia. So, early detection of celiac disease is an important step in prevention of morbidity associated with this chronic disease.
Identifiants
pubmed: 31041208
doi: 10.4103/jfmpc.jfmpc_56_19
pii: JFMPC-8-823
pmc: PMC6482799
doi:
Types de publication
Journal Article
Langues
eng
Pagination
823-827Déclaration de conflit d'intérêts
There are no conflicts of interest.
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