Therapeutically Attenuating Neutrophil Recruitment With a CXCR2 Antagonist in Combination With Oseltamivir Ameliorates Influenza-Induced Lung Injury and Disease.
CXCR2 antagonist
biomarker
influenza
neutrophils
Journal
Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
19
11
2018
accepted:
01
03
2019
entrez:
2
5
2019
pubmed:
2
5
2019
medline:
2
5
2019
Statut:
epublish
Résumé
Mice were infected with influenza and treated with a CXCR2 antagonist in combination with antiviral or antiviral alone starting 4 days postinfection. Neutrophil recruitment to the lung was reduced, and improvements in health outcomes and lung consolidation were observed in combination-treated mice with no evidence of worsening outcome.
Identifiants
pubmed: 31041337
doi: 10.1093/ofid/ofz106
pii: ofz106
pmc: PMC6483135
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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