Association of glucose and blood pressure variability on oxidative stress in patients with type 2 diabetes mellitus and hypertension: a cross-sectional study.
Ambulatory blood pressure monitoring
Blood pressure variability
Continuous glucose monitoring
Glucose variability
Oxidative stress
Type 2 diabetes mellitus
Journal
Diabetology & metabolic syndrome
ISSN: 1758-5996
Titre abrégé: Diabetol Metab Syndr
Pays: England
ID NLM: 101488958
Informations de publication
Date de publication:
2019
2019
Historique:
received:
30
01
2019
accepted:
02
04
2019
entrez:
3
5
2019
pubmed:
3
5
2019
medline:
3
5
2019
Statut:
epublish
Résumé
The present study evaluated the effects of glucose and blood pressure (BP) variability on oxidative stress in patients with type 2 diabetes mellitus (T2DM) and hypertension. A total of 60 inpatients with T2DM underwent continuous glucose monitoring (CGM) and ambulatory BP monitoring (ABPM). Oxidative stress was estimated using the diacron-reactive oxygen metabolites (d-ROMs) test. Glucose variability, mean glucose level, percentage coefficient of variation for glucose, mean amplitude of glycemic excursions (MAGE), and area under the postprandial plasma glucose curve were determined through CGM. BP variability was assessed by measuring average BP, standard deviation (SD) of systolic and diastolic BP, and coefficient of variation (CV) of systolic and diastolic BP during daytime and nighttime ABPM. Participants had a mean age of 64.5 ± 13.3 years with the duration of the disease 13.9 ± 12.4 years and HbA1c of 8.5 ± 1.2%. Univariate analysis showed that MAGE, nighttime SDs of systolic and diastolic BP, and nighttime CV of systolic BP were significantly correlated with d-ROMs. Further, stepwise multiple regression analysis identified MAGE, nighttime SD and CV of diastolic BP, estimated glomerular filtration rate, and smoking as independent contributors to d-ROMs. Oxidative stress was associated with daily glucose and nighttime diastolic BP variability in patients with T2DM and hypertension.
Sections du résumé
BACKGROUND
BACKGROUND
The present study evaluated the effects of glucose and blood pressure (BP) variability on oxidative stress in patients with type 2 diabetes mellitus (T2DM) and hypertension.
METHODS
METHODS
A total of 60 inpatients with T2DM underwent continuous glucose monitoring (CGM) and ambulatory BP monitoring (ABPM). Oxidative stress was estimated using the diacron-reactive oxygen metabolites (d-ROMs) test. Glucose variability, mean glucose level, percentage coefficient of variation for glucose, mean amplitude of glycemic excursions (MAGE), and area under the postprandial plasma glucose curve were determined through CGM. BP variability was assessed by measuring average BP, standard deviation (SD) of systolic and diastolic BP, and coefficient of variation (CV) of systolic and diastolic BP during daytime and nighttime ABPM.
RESULTS
RESULTS
Participants had a mean age of 64.5 ± 13.3 years with the duration of the disease 13.9 ± 12.4 years and HbA1c of 8.5 ± 1.2%. Univariate analysis showed that MAGE, nighttime SDs of systolic and diastolic BP, and nighttime CV of systolic BP were significantly correlated with d-ROMs. Further, stepwise multiple regression analysis identified MAGE, nighttime SD and CV of diastolic BP, estimated glomerular filtration rate, and smoking as independent contributors to d-ROMs.
CONCLUSIONS
CONCLUSIONS
Oxidative stress was associated with daily glucose and nighttime diastolic BP variability in patients with T2DM and hypertension.
Identifiants
pubmed: 31044019
doi: 10.1186/s13098-019-0425-y
pii: 425
pmc: PMC6460855
doi:
Types de publication
Journal Article
Langues
eng
Pagination
29Déclaration de conflit d'intérêts
The authors of this manuscript have the following competing interests: T. Hirano received lecture fees from Kowa, MSD, Takeda, Astra Zeneca, Ono, Novo Nordisk, Eli Lilly, and Boehringer Ingelheim. The other authors declare that they have no competing interests.
Références
Int Angiol. 1999 Jun;18(2):127-30
pubmed: 10424368
Hypertension. 1999 Oct;34(4 Pt 2):943-9
pubmed: 10523389
BMJ. 2000 Aug 12;321(7258):412-9
pubmed: 10938049
Hypertension. 2001 Oct;38(4):852-7
pubmed: 11641298
Hypertension. 2002 Jan;39(1):168-72
pubmed: 11799097
Clin Chem Lab Med. 2002 Feb;40(2):104-10
pubmed: 11939481
N Engl J Med. 2002 Jun 20;346(25):1954-62
pubmed: 12075056
N Engl J Med. 2003 Jan 30;348(5):383-93
pubmed: 12556541
J Hypertens. 2003 Dec;21(12):2251-7
pubmed: 14654744
Clin Biochem. 2005 Jan;38(1):88-91
pubmed: 15607323
Circulation. 2005 Feb 8;111(5):697-716
pubmed: 15699287
Chest. 2005 May;127(5):1674-9
pubmed: 15888845
Diabetes. 2005 Jun;54(6):1615-25
pubmed: 15919781
Hypertension. 2005 Jul;46(1):162-7
pubmed: 15928031
J Clin Endocrinol Metab. 2005 Oct;90(10):5896-903
pubmed: 16014401
World Rev Nutr Diet. 2005;94:1-12
pubmed: 16145245
Int J Cardiol. 2006 Jun 28;110(3):415-6
pubmed: 16293325
JAMA. 2006 Apr 12;295(14):1681-7
pubmed: 16609090
Ann Intern Med. 2006 Jun 20;144(12):884-93
pubmed: 16785477
Clin Exp Hypertens. 2007 Jan;29(1):31-42
pubmed: 17190729
Circulation. 2007 Jan 23;115(3):387-97
pubmed: 17242296
Hypertens Res. 2006 Sep;29(9):695-702
pubmed: 17249525
Am J Hypertens. 2007 Feb;20(2):154-61
pubmed: 17261460
Diabetes. 2008 May;57(5):1349-54
pubmed: 18299315
Clin Exp Hypertens. 2008 Apr;30(3):213-24
pubmed: 18425701
Am J Hypertens. 2009 Jan;22(1):46-51
pubmed: 18833198
Hypertension. 2011 May;57(5):891-7
pubmed: 21403089
Diabetes Care. 2011 Jul;34(7):1605-9
pubmed: 21610126
J Am Coll Cardiol. 2012 Jan 3;59(1):74-83
pubmed: 22192672
Acta Diabetol. 2012 Dec;49 Suppl 1:S171-7
pubmed: 22547264
J Atheroscler Thromb. 2012;19(8):712-7
pubmed: 22785135
Circulation. 2013 Sep 17;128(12):1325-34
pubmed: 23926207
BMC Nephrol. 2013 Sep 09;14:191
pubmed: 24016221
Cardiol J. 2013;20(5):453-63
pubmed: 24469868
Hypertens Res. 2014 Jul;37(7):655-8
pubmed: 24646641
Diabetes Care. 2014 Aug;37(8):2359-65
pubmed: 24812434
J Diabetes Investig. 2010 Oct 19;1(5):212-28
pubmed: 24843435
Diabetes Res Clin Pract. 2016 Dec;122:62-70
pubmed: 27810687
Lancet Diabetes Endocrinol. 2017 Dec;5(12):951-964
pubmed: 29079252
Diabetes Res Clin Pract. 2018 May;139:253-261
pubmed: 29501829
Cardiovasc Diabetol. 2018 Mar 7;17(1):36
pubmed: 29514695
Int J Hypertens. 2018 Apr 23;2018:5126270
pubmed: 29850224
Hypertension. 1986 Feb;8(2):147-53
pubmed: 3080371
Diabetes. 1970 Sep;19(9):644-55
pubmed: 5469118
J Clin Invest. 1996 Apr 15;97(8):1916-23
pubmed: 8621776
Diabetes Care. 1996 Mar;19(3):257-67
pubmed: 8742574
Diabetologia. 1997 Dec;40(12):1470-5
pubmed: 9447956
Circulation. 1998 Jun 9;97(22):2222-9
pubmed: 9631871