NOD-like receptor C4 Inflammasome Regulates the Growth of Colon Cancer Liver Metastasis in NAFLD.

Animals Apoptosis Regulatory Proteins / physiology Calcium-Binding Proteins / physiology Colonic Neoplasms / pathology Female Inflammasomes / physiology Interleukin-1beta / physiology Liver Neoplasms / complications Macrophages / pathology Mice Mice, Inbred C57BL Non-alcoholic Fatty Liver Disease / complications

Journal

Hepatology (Baltimore, Md.)
ISSN: 1527-3350
Titre abrégé: Hepatology
Pays: United States
ID NLM: 8302946

Informations de publication

Date de publication:
11 2019
Historique:
received: 19 12 2018
accepted: 23 04 2019
pubmed: 3 5 2019
medline: 3 7 2020
entrez: 3 5 2019
Statut: ppublish

Résumé

Nonalcoholic fatty liver disease (NAFLD) enhances the growth and recurrence of colorectal cancer (CRC) liver metastasis. With the rising prevalence of NAFLD, a better understanding of the molecular mechanism underlying NAFLD-associated liver metastasis is crucial. Tumor-associated macrophages (TAMs) constitute a large portion of the tumor microenvironment that promotes tumor growth. NOD-like receptor C4 (NLRC4), a component of an inflammasome complex, plays a role in macrophage activation and interleukin (IL)-1β processing. We aimed to investigate whether NLRC4-mediated TAM polarization contributes to metastatic liver tumor growth in NAFLD. Wild-type and NLRC4

Identifiants

DOI: 10.1002/hep.30693 PMID: 31044438 PMC: PMC6819206
pubmed: 31044438
doi: 10.1002/hep.30693
pmc: PMC6819206
mid: NIHMS1026395
doi:

Substances chimiques

Apoptosis Regulatory Proteins 0
Calcium-Binding Proteins 0
IL1B protein, mouse 0
Inflammasomes 0
Interleukin-1beta 0
Ipaf protein, mouse 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1582-1599

Subventions

Organisme : NIAAA NIH HHS
ID : R21 AA025841
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK107288
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK085252
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA163200
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA027036
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI118719
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA233452
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI118719
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL134637
Pays : United States

Informations de copyright

© 2019 by the American Association for the Study of Liver Diseases.

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Auteurs

Koichiro Ohashi (K)

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.

Zhijun Wang (Z)

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Yoon Mee Yang (YM)

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
College of Pharmacy, Kangwon National University, Chuncheon, South Korea.

Sandrine Billet (S)

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.

Wei Tu (W)

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Michael Pimienta (M)

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.

Suzanne L Cassel (SL)

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA.

Stephen J Pandol (SJ)

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Department of Medicine, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA.

Shelly C Lu (SC)

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Department of Medicine, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA.

Fayyaz S Sutterwala (FS)

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA.

Neil Bhowmick (N)

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA.
Department of Medicine, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA.

Ekihiro Seki (E)

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA.
Department of Medicine, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA.
ORCID: 0000-0002-9472-6085

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › NOD-like receptor C4 Inflammasome Regulates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › NOD-like receptor C4 Inflammasome Regulates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Protéines de liaison au calcium › NOD-like receptor C4 Inflammasome Regulates...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Tumeurs de l'intestin › Tumeurs du côlon › NOD-like receptor C4 Inflammasome Regulates...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Inflammasomes › NOD-like receptor C4 Inflammasome Regulates...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Monokines › Interleukine-1 › Interleukine-1 bêta › NOD-like receptor C4 Inflammasome Regulates...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › NOD-like receptor C4 Inflammasome Regulates...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › NOD-like receptor C4 Inflammasome Regulates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › NOD-like receptor C4 Inflammasome Regulates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › NOD-like receptor C4 Inflammasome Regulates...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Stéatose hépatique › Stéatose hépatique non alcoolique › NOD-like receptor C4 Inflammasome Regulates...