m6Acomet: large-scale functional prediction of individual m
Journal
BMC bioinformatics
ISSN: 1471-2105
Titre abrégé: BMC Bioinformatics
Pays: England
ID NLM: 100965194
Informations de publication
Date de publication:
02 May 2019
02 May 2019
Historique:
received:
22
10
2018
accepted:
22
04
2019
entrez:
4
5
2019
pubmed:
3
5
2019
medline:
14
6
2019
Statut:
epublish
Résumé
Over one hundred different types of post-transcriptional RNA modifications have been identified in human. Researchers discovered that RNA modifications can regulate various biological processes, and RNA methylation, especially N6-methyladenosine, has become one of the most researched topics in epigenetics. To date, the study of epitranscriptome layer gene regulation is mostly focused on the function of mediator proteins of RNA methylation, i.e., the readers, writers and erasers. There is limited investigation of the functional relevance of individual m An online web server m6Acomet was constructed to support direct query for the predicted biological functions of m
Sections du résumé
BACKGROUND
BACKGROUND
Over one hundred different types of post-transcriptional RNA modifications have been identified in human. Researchers discovered that RNA modifications can regulate various biological processes, and RNA methylation, especially N6-methyladenosine, has become one of the most researched topics in epigenetics.
RESULTS
RESULTS
To date, the study of epitranscriptome layer gene regulation is mostly focused on the function of mediator proteins of RNA methylation, i.e., the readers, writers and erasers. There is limited investigation of the functional relevance of individual m
CONCLUSIONS
CONCLUSIONS
An online web server m6Acomet was constructed to support direct query for the predicted biological functions of m
Identifiants
pubmed: 31046660
doi: 10.1186/s12859-019-2840-3
pii: 10.1186/s12859-019-2840-3
pmc: PMC6498663
doi:
Substances chimiques
N-methyladenosine
CLE6G00625
Adenosine
K72T3FS567
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
223Subventions
Organisme : National Natural Science Foundation of China
ID : 31671373
Organisme : National Natural Science Foundation of China
ID : 61501466
Organisme : Jiangsu University Natural Science Program
ID : 16KJB180027
Organisme : XJTLU Key Programme Special Fund
ID : KSF-T-01
Organisme : Six Talent Peaks Project in Jiangsu Province
ID : XYDXX-118
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