A high blood eosinophil count may be a risk factor for incident asthma in population at risk.
Adult
Age Factors
Aged
Asthma
/ epidemiology
Bronchitis
/ epidemiology
Cell Count
China
/ epidemiology
Cohort Studies
Eosinophils
/ metabolism
Female
Humans
Longitudinal Studies
Male
Middle Aged
Multivariate Analysis
Nasal Polyps
/ epidemiology
Pneumonia
/ epidemiology
Proportional Hazards Models
Pulmonary Disease, Chronic Obstructive
/ epidemiology
Risk Factors
Sex Factors
Young Adult
Blood eosinophil counts
Incident asthma
Risk factor
Journal
Respiratory medicine
ISSN: 1532-3064
Titre abrégé: Respir Med
Pays: England
ID NLM: 8908438
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
02
11
2018
revised:
23
03
2019
accepted:
26
03
2019
entrez:
4
5
2019
pubmed:
3
5
2019
medline:
7
5
2020
Statut:
ppublish
Résumé
Eosinophilia is considered to be associated with allergic disease and may predict asthma exacerbation. Eosinophils contribute to the pathophysiology and pathogenesis of asthma. However, studies on high blood eosinophil counts (BECs) and incident asthma remain scarce. To examine whether high BECs are positively associated with incident asthma in adults. Our study included 57975 participants aged from 20 to 79 years from the Shandong multi-center health check-up longitudinal study for Health Management. All patients with determined baseline BECs were ≥20 years old and free from asthma. We defined incident asthma as self-reported new-onset asthma occurring during the 10-year follow-up period. Multivariate modeling employed Poisson regression and Cox proportional hazards models to verify the association between BEC and incident asthma by adjusting demographics and some relevant comorbidities (rhinitis, nasal polyps, pneumonia, bronchitis, and chronic obstructive pulmonary disease). A BEC ≥110 cells/μL was a risk factor for incident asthma (adjusted IRR = 1.62, 95% CI: 1.05-2.50, P = .028) in the Poisson regression. In the Cox proportional hazards model, the BEC cutoff point for incident asthma was also determined to be 110 cells/μL (HR = 1.59, 95% CI: 1.01-2.51, P = .045). A high BEC is a risk factor for incident asthma, especially when the BEC exceeds 110 cells/μL. This suggests that adults with high BECs are more likely to develop asthma.
Sections du résumé
BACKGROUND
Eosinophilia is considered to be associated with allergic disease and may predict asthma exacerbation. Eosinophils contribute to the pathophysiology and pathogenesis of asthma. However, studies on high blood eosinophil counts (BECs) and incident asthma remain scarce.
OBJECTIVE
To examine whether high BECs are positively associated with incident asthma in adults.
METHODS
Our study included 57975 participants aged from 20 to 79 years from the Shandong multi-center health check-up longitudinal study for Health Management. All patients with determined baseline BECs were ≥20 years old and free from asthma. We defined incident asthma as self-reported new-onset asthma occurring during the 10-year follow-up period. Multivariate modeling employed Poisson regression and Cox proportional hazards models to verify the association between BEC and incident asthma by adjusting demographics and some relevant comorbidities (rhinitis, nasal polyps, pneumonia, bronchitis, and chronic obstructive pulmonary disease).
RESULTS
A BEC ≥110 cells/μL was a risk factor for incident asthma (adjusted IRR = 1.62, 95% CI: 1.05-2.50, P = .028) in the Poisson regression. In the Cox proportional hazards model, the BEC cutoff point for incident asthma was also determined to be 110 cells/μL (HR = 1.59, 95% CI: 1.01-2.51, P = .045).
CONCLUSION
A high BEC is a risk factor for incident asthma, especially when the BEC exceeds 110 cells/μL. This suggests that adults with high BECs are more likely to develop asthma.
Identifiants
pubmed: 31047119
pii: S0954-6111(19)30091-5
doi: 10.1016/j.rmed.2019.03.016
pii:
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
59-65Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.