Verification and monitoring of visceral leishmaniasis in hamsters caused by Leishmania infantum, using non-invasive approaches involving ultrasound imaging and blood gases.
Animals
Blood Chemical Analysis
Blood Gas Analysis
Cricetinae
Disease Models, Animal
Female
Hematologic Tests
Kidney
/ diagnostic imaging
Leishmania infantum
/ classification
Leishmaniasis, Visceral
/ blood
Liver
/ diagnostic imaging
Male
Mesocricetus
Real-Time Polymerase Chain Reaction
Sex Factors
Spleen
/ diagnostic imaging
Ultrasonography
Weight Gain
Blood gases
Hamsters
Leishmania infantum
Ultrasound
visceral leishmaniasis
Journal
Experimental parasitology
ISSN: 1090-2449
Titre abrégé: Exp Parasitol
Pays: United States
ID NLM: 0370713
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
02
02
2018
revised:
22
04
2019
accepted:
24
04
2019
pubmed:
3
5
2019
medline:
5
6
2019
entrez:
4
5
2019
Statut:
ppublish
Résumé
Hamsters are a suitable experimental model for visceral leishmaniasis (VL) because they mimic the features of the human disease. However, the infection after inoculation can only be verified after sacrifice of the animal or several months following infection, when obvious signs of the disease appear, compromising animal welfare in both cases. Unlike other studies, the present work used an inoculum of 5 × 10
Identifiants
pubmed: 31047987
pii: S0014-4894(18)30057-2
doi: 10.1016/j.exppara.2019.04.012
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
78-89Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.