Evaluation of BBB permeable nucleolipid (NL

Animals Blood-Brain Barrier / metabolism Brain Neoplasms / metabolism Cell Line, Tumor Female HEK293 Cells Humans Hydrocarbons / administration & dosage Ketones / administration & dosage Mice, Inbred BALB C Permeability Rabbits Radiopharmaceuticals / administration & dosage Technetium Tc 99m Pentetate / administration & dosage Tissue Distribution Tomography, Emission-Computed, Single-Photon Uridine / administration & dosage
BBB permeable Brain-imaging Nucleolipid Nucleoside tracer Radiotracer SPECT imaging

Journal

International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127

Informations de publication

Date de publication:
30 Jun 2019
Historique:
received: 06 12 2018
revised: 16 04 2019
accepted: 27 04 2019
pubmed: 3 5 2019
medline: 18 12 2019
entrez: 4 5 2019
Statut: ppublish

Résumé

Despite being in routine for onco-diagnostics for years, the applicability of nucleosidic molecular imaging probes is severely restricted in neurological applications due to their low permeability across blood-brain-barrier (BBB). For extending nucleoside tracers utility for neuro-onco early diagnostics, suitable modification which enhances their BBB permeation needs investigation. Among various modifications, lipidization of nucleosides has been reported to enhance cellular permeability. Extending the concept, the aim was to exemplify the possibility of lipidized nucleosides as potential brain tracer with capability to cross intact BBB and evaluate as metal based neuro-imaging SPECT agent. Uridine based non-lipidic (NS

Identifiants

DOI: 10.1016/j.ijpharm.2019.04.074 PMID: 31047994
pubmed: 31047994
pii: S0378-5173(19)30345-X
doi: 10.1016/j.ijpharm.2019.04.074
pii:
doi:

Substances chimiques

Hydrocarbons 0
Ketones 0
Radiopharmaceuticals 0
palmitone GR7I8IC3NO
Technetium Tc 99m Pentetate VW78417PU1
Uridine WHI7HQ7H85

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

269-282

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, Brig. S. K. Mazumdar Road, Delhi 110054, India; Department of Chemistry, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Shubhra Chaturvedi (S)

Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, Brig. S. K. Mazumdar Road, Delhi 110054, India.

Ankur Kaul (A)

Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, Brig. S. K. Mazumdar Road, Delhi 110054, India.

Puja Panwar Hazari (PP)

Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, Brig. S. K. Mazumdar Road, Delhi 110054, India.

Preeti Jha (P)

Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, Brig. S. K. Mazumdar Road, Delhi 110054, India.

Sunil Pal (S)

Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, Brig. S. K. Mazumdar Road, Delhi 110054, India.

Sangeeta Lal (S)

School of Physical Sciences, Jawaharlal Nehru University, Delhi 110067, India.

B Singh (B)

Department of Chemistry, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Philippe Barthélémy (P)

INSERM U1212 and Université de Bordeaux, Bordeaux F-33076, France. Electronic address: philippe.barthelemy@inserm.fr.

Anil K Mishra (AK)

Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, Brig. S. K. Mazumdar Road, Delhi 110054, India. Electronic address: akmishra@inmas.drdo.in.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Evaluation of BBB permeable nucleolipid (NL
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Barrière hémato-encéphalique › Evaluation of BBB permeable nucleolipid (NL
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Evaluation of BBB permeable nucleolipid (NL
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Evaluation of BBB permeable nucleolipid (NL
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Evaluation of BBB permeable nucleolipid (NL
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Evaluation of BBB permeable nucleolipid (NL
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Evaluation of BBB permeable nucleolipid (NL
questionsmedicales.fr › Composés chimiques organiques › Cétones › Evaluation of BBB permeable nucleolipid (NL
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Evaluation of BBB permeable nucleolipid (NL
questionsmedicales.fr › Phénomènes chimiques › Perméabilité › Evaluation of BBB permeable nucleolipid (NL
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Lagomorpha › Lapins › Evaluation of BBB permeable nucleolipid (NL
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Radiopharmaceutiques › Evaluation of BBB permeable nucleolipid (NL
questionsmedicales.fr › Composés chimiques organiques › Composés organométalliques › Composés organiques du technétium › Pentétate de technétium (99mTc) › Evaluation of BBB permeable nucleolipid (NL
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Evaluation of BBB permeable nucleolipid (NL
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission monophotonique › Evaluation of BBB permeable nucleolipid (NL
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Uridine › Evaluation of BBB permeable nucleolipid (NL