Expression of factor V by resident macrophages boosts host defense in the peritoneal cavity.
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
03 06 2019
03 06 2019
Historique:
received:
29
10
2018
revised:
25
03
2019
accepted:
08
04
2019
pubmed:
3
5
2019
medline:
15
4
2020
entrez:
4
5
2019
Statut:
ppublish
Résumé
Macrophages resident in different organs express distinct genes, but understanding how this diversity fits into tissue-specific features is limited. Here, we show that selective expression of coagulation factor V (FV) by resident peritoneal macrophages in mice promotes bacterial clearance in the peritoneal cavity and serves to facilitate the well-known but poorly understood "macrophage disappearance reaction." Intravital imaging revealed that resident macrophages were nonadherent in peritoneal fluid during homeostasis. Bacterial entry into the peritoneum acutely induced macrophage adherence and associated bacterial phagocytosis. However, optimal control of bacterial expansion in the peritoneum also required expression of FV by the macrophages to form local clots that effectively brought macrophages and bacteria in proximity and out of the fluid phase. Thus, acute cellular adhesion and resident macrophage-induced coagulation operate independently and cooperatively to meet the challenges of a unique, open tissue environment. These events collectively account for the macrophage disappearance reaction in the peritoneal cavity.
Identifiants
pubmed: 31048328
pii: jem.20182024
doi: 10.1084/jem.20182024
pmc: PMC6547866
doi:
Substances chimiques
Factor V
9001-24-5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1291-1300Subventions
Organisme : NIAID NIH HHS
ID : R37 AI049653
Pays : United States
Organisme : NIDDK NIH HHS
ID : DP1 DK109668
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007163
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI113118
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL118206
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK052574
Pays : United States
Informations de copyright
© 2019 Zhang et al.
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