Protocol for the development of a core outcome set for cauda equina syndrome: systematic literature review, qualitative interviews, Delphi survey and consensus meeting.
Delphi
cauda equina syndrome
consensus
core outcome set
qualitative interviews
systematic literature review
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
01 05 2019
01 05 2019
Historique:
entrez:
4
5
2019
pubmed:
3
5
2019
medline:
24
4
2020
Statut:
epublish
Résumé
Cauda equina syndrome (CES) is a serious neurological condition most commonly due to compression of the lumbosacral nerve roots, which can result in significant disability. The evidence for acute intervention in CES is mainly from retrospective studies. There is heterogeneity in the outcomes chosen for analysis in these studies, which makes it difficult to synthesise the data across studies. This study will develop a core outcome set for use in future studies of CES, engaging with key stakeholders and using transparent methodology. This will help ensure that relevant outcomes are used in future and will facilitate attempts to summarise data across studies in systematic reviews. A systematic literature review will document all the outcomes for CES after surgery mentioned in the literature. The qualitative interviews with patients with CES will be semistructured, audio recorded, transcribed and thematically analysed with the use of NVivo V.10 to identify outcomes and determine the themes described. The outcomes from the literature review and patient interviews will be combined and prioritised to determine what the most important outcomes are in CES research studies to patients and healthcare professionals. The prioritisation will be done through a two-round iterative Delphi survey and a consensus meeting. This process will decide the core outcome set for patients with CES. REC and HRA approval was obtained on the 6/12/16 for the qualitative interviews from South Central-Hampshire A REC. REC reference 16/SC/0587. REC and HRA approval was obtained on 26/3/18 for the Delphi process and consensus meeting from North West-Greater Manchester Central REC. REC reference was 18/NW/0022. The final core outcome set will be published and freely available. This study is registered with the Core Outcome Measures in Effectiveness Trials database as study 824.
Identifiants
pubmed: 31048424
pii: bmjopen-2018-024002
doi: 10.1136/bmjopen-2018-024002
pmc: PMC6502054
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e024002Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Orthopedics. 2012 Mar 07;35(3):e414-9
pubmed: 22385455
Trials. 2012 Aug 06;13:132
pubmed: 22867278
Health Technol Assess. 1998;2(3):i-iv, 1-88
pubmed: 9561895
PLoS Med. 2011 Jan 25;8(1):e1000393
pubmed: 21283604
J Clin Epidemiol. 2010 Jun;63(6):620-6
pubmed: 20434024
Trials. 2013 Jan 22;14:21
pubmed: 23339751
Trials. 2016 May 04;17(1):230
pubmed: 27142835
Int J Qual Health Care. 2007 Dec;19(6):349-57
pubmed: 17872937
J Clin Epidemiol. 2018 Apr;96:84-92
pubmed: 29288712
Orthopedics. 2009 Jun 1;32(6):397
pubmed: 19711885
Neurosurg Focus. 2004 Jun 15;16(6):e8
pubmed: 15202878
Bone Joint J. 2014 Aug;96-B(8):1016-23
pubmed: 25086115
J Adv Nurs. 2008 Apr;62(1):107-15
pubmed: 18352969
Spine (Phila Pa 1976). 2018 Sep 1;43(17):E1005-E1013
pubmed: 29432394
Br J Neurosurg. 2002 Aug;16(4):325-8
pubmed: 12389883
Nurse Res. 2006 Jul 1;13(4):84
pubmed: 27702218
PLoS Med. 2009 Jul 21;6(7):e1000097
pubmed: 19621072
PLoS Med. 2017 Nov 16;14(11):e1002447
pubmed: 29145404
Am J Orthop (Belle Mead NJ). 2008 Nov;37(11):556-62
pubmed: 19104682
Res Involv Engagem. 2016 Jul 8;2:25
pubmed: 29507761
BMJ. 2008 Apr 26;336(7650):924-6
pubmed: 18436948
Trials. 2016 Sep 13;17(1):449
pubmed: 27618914
Trials. 2015 Feb 12;16:47
pubmed: 25887033
Spine (Phila Pa 1976). 2015 Apr 15;40(8):580-3
pubmed: 25646751
Br J Neurosurg. 2005 Aug;19(4):301-6; discussion 307-8
pubmed: 16455534
BMJ. 1995 Jul 22;311(6999):251-3
pubmed: 7627048
Br J Surg. 2015 Oct;102(11):1360-71
pubmed: 26179938
BMJ. 2008 Jul 31;337:a744
pubmed: 18669566
Trials. 2007 Nov 26;8:38
pubmed: 18039364
BMJ. 2004 Jun 19;328(7454):1490
pubmed: 15205295
Trials. 2013 Mar 12;14:70
pubmed: 23497540
Eur Spine J. 2011 May;20(5):690-7
pubmed: 21193933
J Adv Nurs. 2000 Oct;32(4):1008-15
pubmed: 11095242
Trials. 2017 Jun 20;18(Suppl 3):280
pubmed: 28681707
J Public Health (Oxf). 2011 Mar;33(1):147-50
pubmed: 21345890
Spine (Phila Pa 1976). 2000 Jun 15;25(12):1515-22
pubmed: 10851100