Targeting RIPK1 for the treatment of human diseases.
RIPK1
apoptosis
inflammation
necroptosis
neurodegeneration
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
14 05 2019
14 05 2019
Historique:
pubmed:
3
5
2019
medline:
27
3
2020
entrez:
4
5
2019
Statut:
ppublish
Résumé
RIPK1 kinase has emerged as a promising therapeutic target for the treatment of a wide range of human neurodegenerative, autoimmune, and inflammatory diseases. This was supported by extensive studies which demonstrated that RIPK1 is a key mediator of apoptotic and necrotic cell death as well as inflammatory pathways. Furthermore, human genetic evidence has linked the dysregulation of RIPK1 to the pathogenesis of ALS as well as other inflammatory and neurodegenerative diseases. Importantly, unique allosteric small-molecule inhibitors of RIPK1 that offer high selectivity have been developed. These molecules can penetrate the blood-brain barrier, thus offering the possibility to target neuroinflammation and cell death which drive various neurologic conditions including Alzheimer's disease, ALS, and multiple sclerosis as well as acute neurological diseases such as stroke and traumatic brain injuries. We discuss the current understanding of RIPK1 regulatory mechanisms and emerging evidence for the pathological roles of RIPK1 in human diseases, especially in the context of the central nervous systems.
Identifiants
pubmed: 31048504
pii: 1901179116
doi: 10.1073/pnas.1901179116
pmc: PMC6525537
doi:
Substances chimiques
Tumor Necrosis Factor-alpha
0
RIPK1 protein, human
EC 2.7.11.1
Receptor-Interacting Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
9714-9722Subventions
Organisme : NIA NIH HHS
ID : R21 AG059073
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG055521
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA190542
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI124049
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG058642
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG047231
Pays : United States
Informations de copyright
Copyright © 2019 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
Conflict of interest statement: J.Y. is a consultant for Denali Therapeutics. D.O. is an employee of Sanofi.
Références
Trends Pharmacol Sci. 1999 Feb;20(2):46-51
pubmed: 10101962
Genes Dev. 1999 Oct 1;13(19):2514-26
pubmed: 10521396
Exp Cell Res. 2000 Apr 10;256(1):67-73
pubmed: 10739653
Free Radic Biol Med. 2000 Aug;29(3-4):323-33
pubmed: 11035261
Am J Med Genet. 2000 Dec 4;96(6):823-30
pubmed: 11121190
Mol Cell Biol. 2001 Aug;21(16):5299-305
pubmed: 11463813
Nat Neurosci. 2001 Nov;4(11):1116-22
pubmed: 11600888
Oncogene. 2003 Nov 24;22(53):8543-67
pubmed: 14634618
Mol Cell. 2004 Aug 27;15(4):535-48
pubmed: 15327770
Neuron. 2004 Sep 30;44(1):181-93
pubmed: 15450169
Nat Chem Biol. 2005 Jul;1(2):112-9
pubmed: 16408008
Neurodegener Dis. 2005;2(5):233-41
pubmed: 16909003
Cell Death Differ. 2007 Jan;14(1):73-8
pubmed: 16946729
Cardiovasc Drugs Ther. 2007 Aug;21(4):227-33
pubmed: 17665295
Nat Chem Biol. 2008 May;4(5):313-21
pubmed: 18408713
J Cereb Blood Flow Metab. 2008 Sep;28(9):1564-73
pubmed: 18493258
Mol Cell. 2008 Jun 20;30(6):689-700
pubmed: 18570872
Cell. 2008 Dec 26;135(7):1311-23
pubmed: 19109899
Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20960-5
pubmed: 19933335
J Neurosci Res. 2010 May 15;88(7):1569-76
pubmed: 20025059
Curr Opin Cell Biol. 2010 Apr;22(2):263-8
pubmed: 20045303
CNS Neurol Disord Drug Targets. 2010 Apr;9(2):156-67
pubmed: 20205644
J Neurosci Res. 2011 May;89(5):639-49
pubmed: 21344476
Nature. 2011 Mar 17;471(7338):363-7
pubmed: 21368763
Nature. 2011 Mar 31;471(7340):591-6
pubmed: 21455173
Ann Neurol. 2011 Jun;69(6):940-53
pubmed: 21472771
Nat Cell Biol. 2011 Oct 30;13(12):1437-42
pubmed: 22037414
Immunity. 2011 Dec 23;35(6):908-18
pubmed: 22195746
Cell. 2012 Jan 20;148(1-2):213-27
pubmed: 22265413
Cell Host Microbe. 2012 Mar 15;11(3):290-7
pubmed: 22423968
Cell Death Dis. 2012 Jun 14;3:e320
pubmed: 22695613
Nature. 2012 Aug 23;488(7412):508-511
pubmed: 22801493
Cell. 2012 Jul 20;150(2):339-50
pubmed: 22817896
Biomed J. 2012 Nov-Dec;35(6):437-49
pubmed: 23442356
PLoS One. 2013;8(3):e56576
pubmed: 23469174
Structure. 2013 Mar 5;21(3):493-9
pubmed: 23473668
Nat Neurosci. 2013 May;16(5):571-9
pubmed: 23542689
Nature. 2013 Jun 13;498(7453):224-7
pubmed: 23708968
Cell Death Dis. 2013 Jul 11;4:e716
pubmed: 23846218
J Biol Chem. 2013 Oct 25;288(43):31268-79
pubmed: 24019532
PLoS One. 2013 Oct 02;8(10):e76841
pubmed: 24098568
Nat Rev Mol Cell Biol. 2013 Nov;14(11):727-36
pubmed: 24129419
Nat Med. 2014 Feb;20(2):204-8
pubmed: 24441827
Exp Eye Res. 2014 Jun;123:1-7
pubmed: 24751757
Cell. 2014 May 22;157(5):1175-88
pubmed: 24813849
Cell. 2014 May 22;157(5):1189-202
pubmed: 24813850
Cell Rep. 2014 May 22;7(4):971-81
pubmed: 24813885
Proc Natl Acad Sci U S A. 2014 May 27;111(21):7753-8
pubmed: 24821786
J Immunol. 2014 Jun 15;192(12):5476-80
pubmed: 24821972
J Immunol. 2014 Aug 15;193(4):1539-1543
pubmed: 25015821
Semin Cell Dev Biol. 2014 Nov;35:14-23
pubmed: 25087983
Science. 2015 Mar 27;347(6229):1436-41
pubmed: 25700176
Cell Rep. 2015 Mar 24;10(11):1836-49
pubmed: 25801023
Cell Rep. 2015 Mar 24;10(11):1850-60
pubmed: 25801024
Nat Neurosci. 2015 May;18(5):631-6
pubmed: 25803835
Cell Death Dis. 2015 May 21;6:e1767
pubmed: 25996294
Mol Cell. 2015 Oct 1;60(1):63-76
pubmed: 26344099
Nature. 2015 Oct 29;526(7575):660-5
pubmed: 26375003
Nature. 2015 Oct 29;526(7575):666-71
pubmed: 26375259
Pharmacol Res. 2016 Jan;103:26-48
pubmed: 26529477
Mol Neurodegener. 2016 Feb 03;11:14
pubmed: 26842216
J Med Chem. 2016 Mar 10;59(5):2163-78
pubmed: 26854747
Trends Cell Biol. 2016 Jun;26(6):445-461
pubmed: 26877205
Science. 2016 Apr 1;352(6281):aaf2154
pubmed: 27034377
Sci Rep. 2016 Apr 15;6:24547
pubmed: 27080932
Cell Death Differ. 2016 Sep 1;23(9):1565-76
pubmed: 27177019
Cell Death Differ. 2016 Oct;23(10):1628-37
pubmed: 27258786
Nat Neurosci. 2016 Aug;19(8):995-8
pubmed: 27294511
Immunity. 2016 Jul 19;45(1):46-59
pubmed: 27396959
Science. 2016 Aug 5;353(6299):603-8
pubmed: 27493188
Toxicol Appl Pharmacol. 2016 Oct 1;308:1-10
pubmed: 27521978
Cell Rep. 2016 Aug 30;16(9):2271-80
pubmed: 27545878
Mol Cell. 2016 Sep 15;63(6):990-1005
pubmed: 27591049
Curr Eye Res. 2017 May;42(5):771-779
pubmed: 27732109
Nature. 2016 Dec 1;540(7631):124-128
pubmed: 27819681
Nature. 2016 Dec 1;540(7631):129-133
pubmed: 27819682
Trends Biochem Sci. 2017 Apr;42(4):245-254
pubmed: 27932073
J Med Chem. 2017 Feb 23;60(4):1247-1261
pubmed: 28151659
PLoS One. 2017 Feb 8;12(2):e0171923
pubmed: 28178353
Cell. 2017 Apr 06;169(2):301-313.e11
pubmed: 28366204
J Immunol. 2017 Jun 1;198(11):4435-4447
pubmed: 28461567
Immunol Rev. 2017 May;277(1):61-75
pubmed: 28462526
Mol Cell. 2017 Jun 1;66(5):698-710.e5
pubmed: 28506461
Cell Death Differ. 2017 Aug;24(8):1459-1469
pubmed: 28574501
Cell. 2017 Jun 15;169(7):1276-1290.e17
pubmed: 28602351
Nat Neurosci. 2017 Sep;20(9):1236-1246
pubmed: 28758999
Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7450-E7459
pubmed: 28827318
Nat Commun. 2017 Aug 25;8(1):359
pubmed: 28842570
J Clin Invest. 2017 Sep 1;127(9):3240-3249
pubmed: 28862638
Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8788-E8797
pubmed: 28904096
Medicines (Basel). 2016 Jul 01;3(3):null
pubmed: 28930126
PLoS One. 2017 Oct 6;12(10):e0185777
pubmed: 28985224
Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11944-11949
pubmed: 29078411
Neuroscience. 2018 Feb 10;371:60-74
pubmed: 29102662
Nat Cell Biol. 2018 Jan;20(1):58-68
pubmed: 29203883
Pharmacol Res Perspect. 2017 Dec;5(6):
pubmed: 29226626
Neuroscience. 2018 Feb 10;371:229-241
pubmed: 29247776
Cell Death Dis. 2018 Feb 12;9(2):211
pubmed: 29434255
Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2001-E2009
pubmed: 29440439
Mol Cell. 2018 Feb 15;69(4):566-580.e5
pubmed: 29452637
Cell Rep. 2018 Feb 20;22(8):2066-2079
pubmed: 29466734
J Med Chem. 2018 Mar 22;61(6):2384-2409
pubmed: 29485864
Cell Death Dis. 2018 Mar 2;9(3):359
pubmed: 29500402
Cell Death Differ. 2018 Jun;25(6):1107-1117
pubmed: 29666472
Cell Death Dis. 2018 Apr 27;9(5):500
pubmed: 29703889
Front Immunol. 2018 Apr 30;9:925
pubmed: 29760711
Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5944-E5953
pubmed: 29891719
Science. 2018 Aug 24;361(6404):810-813
pubmed: 30026316
Front Pharmacol. 2018 Jul 06;9:721
pubmed: 30034339
Cell. 2018 Sep 6;174(6):1477-1491.e19
pubmed: 30146158
Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9192-E9200
pubmed: 30209212
Nat Commun. 2018 Sep 25;9(1):3910
pubmed: 30254289
Cell Death Differ. 2019 Jan;26(1):99-114
pubmed: 30341423
Science. 2018 Nov 30;362(6418):1064-1069
pubmed: 30361383
Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10888-E10897
pubmed: 30381458
Mol Genet Metab. 2018 Dec;125(4):345-350
pubmed: 30392741
Glia. 2018 Dec;66(12):2550-2562
pubmed: 30417428
Nat Cell Biol. 2018 Dec;20(12):1389-1399
pubmed: 30420664
Cancer Cell. 2018 Nov 12;34(5):757-774.e7
pubmed: 30423296
Nat Rev Neurosci. 2019 Jan;20(1):19-33
pubmed: 30467385
Trends Biochem Sci. 2019 Jan;44(1):53-63
pubmed: 30509860
Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):970-975
pubmed: 30591564
Ann Neurol. 1988 Apr;23(4):339-46
pubmed: 3132891
Trends Cell Biol. 1998 Sep;8(9):365-72
pubmed: 9728398